1. Gene
  2. ZBTB4 - zinc finger and BTB domain containing 4 Gene

ZBTB4 - zinc finger and BTB domain containing 4 Gene

中文名称:含锌指和 BTB 域 4

种属: Homo sapiens

同用名: ZNF903; KAISO-L1

基因 ID: 57659 | 基因类型: protein coding

关于 ZBTB4

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,459,378-7,484,249 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 191 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 24.8), thyroid (RPKM 20.6) and 25 other tissues.

功能概要

启用多种功能,包括 DNA 结合转录抑制活性、RNA 聚合酶 II 特异性;甲基-CpNpG 结合活性;和序列特异性 DNA 结合活性。参与细胞对 DNA 损伤刺激的反应和 RNA 聚合酶 II 对转录的负调节。位于细胞质和核体中。 [由基因组资源联盟提供,2022 年 4 月]

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; methyl-CpNpG binding activity; and sequence-specific DNA binding activity. Involved in cellular response to DNA damage stimulus and negative regulation of transcription by RNA polymerase II. Located in cytosol and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

ZBTB4 基因产物(2)

mRNA Protein Name
NM_001128833.2 NP_001122305.1 zinc finger and BTB domain-containing protein 4
NM_020899.4 NP_065950.2 zinc finger and BTB domain-containing protein 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
16354688 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
16354688 GOA
enables methyl-CpG binding IDA
IDA: 通过直接分析推断
16354688 GOA
enables methyl-CpNpG binding IDA
IDA: 通过直接分析推断
20403812 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16354688 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
16354688 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
19448668 GOA
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
20403812 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IDA
IDA: 通过直接分析推断
19448668 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
16354688 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16354688 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
16354688 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ZBTB4 蛋白结构

BTB

BTB: BTB/POZ domain (20 - 61)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (235 - 256)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (309 - 331)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (726 - 748)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (765 - 783)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1013 a.a.
蛋白主名 其他名称

zinc finger and BTB domain-containing protein 4

KAISO-like zinc finger protein 1

ZBTB4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZBTB4 Q9P1Z0 CCDC57 Homo sapiens Q2TAC2-2
Y2H Prey Pooling
32296183
种属内
ZBTB4 Q9P1Z0 CCDC57 Homo sapiens Q2TAC2-2
Y2H Array
32296183
种属内
ZBTB4 Q9P1Z0 BANP Homo sapiens Q8N9N5-2
Y2H Array
32296183
种属内
ZBTB4 Q9P1Z0 BANP Homo sapiens Q8N9N5-2
Y2H Prey Pooling
32296183
种属内
ZBTB4 Q9P1Z0 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
种属内
ZBTB4 Q9P1Z0 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
种属内
ZBTB4 Q9P1Z0 POU6F2 Homo sapiens P78424
Y2H Array
32296183
种属内
ZBTB4 Q9P1Z0 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
种属内
ZBTB4 Q9P1Z0 PIBF1 Homo sapiens Q4G0R1
Y2H Array
32296183
种属内
ZBTB4 Q9P1Z0 PIBF1 Homo sapiens Q4G0R1
Y2H Prey Pooling
32296183
种属内
ZBTB4 Q9P1Z0 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
种属内
ZBTB4 Q9P1Z0 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
种属内
ZBTB4 Q9P1Z0 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
种属内
ZBTB4 Q9P1Z0 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
种属内
ZBTB4 Q9P1Z0 CALCOCO2 Homo sapiens Q13137
Y2H Array
32296183
种属内
ZBTB4 Q9P1Z0 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
32296183
种属内
ZBTB4 Q9P1Z0 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
种属内
ZBTB4 Q9P1Z0 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
种属内
ZBTB4 Q9P1Z0 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
32296183
种属内
ZBTB4 Q9P1Z0 TRIM23 Homo sapiens P36406
Y2H Array
32296183
种属内
ZBTB4 Q9P1Z0 KLHL12 Homo sapiens Q53G59
Y2H Prey Pooling
32296183
种属内
ZBTB4 Q9P1Z0 KLHL12 Homo sapiens Q53G59
Y2H Array
32296183
种属内
ZBTB4 Q9P1Z0 CEP76 Homo sapiens Q8TAP6
Y2H Array
32296183
种属内
ZBTB4 Q9P1Z0 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
32296183
种属内
ZBTB4 Q9P1Z0 HOMER3 Homo sapiens Q9NSC5
Y2H Prey Pooling
32296183
种属内
ZBTB4 Q9P1Z0 HOMER3 Homo sapiens Q9NSC5
Y2H Array
32296183
种属内
ZBTB4 Q9P1Z0 PDE4DIP Homo sapiens Q5VU43-2
Y2H Prey Pooling
32296183
种属内
ZBTB4 Q9P1Z0 PDE4DIP Homo sapiens Q5VU43-2
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

Icf Syndrome

Immunodeficiency Syndrome, Variable

Ciid

Centromeric Instability, Immunodeficiency Syndrome

Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16

Icf

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ZBTB4 VGNC VGNC:79414
Canis familiaris ZBTB4 VGNC VGNC:53483
Rattus norvegicus ZBTB4 RGD RGD:1307184
Felis catus ZBTB4 VGNC VGNC:99577
Bos taurus ZBTB4 VGNC VGNC:37078
Mus musculus ZBTB4 MGD MGI:1922830
Others ZBTB4 NCBI