2. Gene
  3. PSMD14 - proteasome 26S subunit, non-ATPase 14 Gene

PSMD14 - proteasome 26S subunit, non-ATPase 14 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白酶体 26S 亚基，非 ATPase 14

种属: Homo sapiens

同用名: PAD1; POH1; RPN11

基因 ID: 10213 | 基因类型: protein coding

关于 PSMD14

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:161,308,425-161,411,717 (from NCBI)

This gene has 5 transcripts (splice variants), 211 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 24.9), testis (RPKM 22.1) and 25 other tissues.

功能概要

该基因编码 26S 蛋白酶体的一个成分。 26S 蛋白酶体是一种大型多蛋白复合物，可催化泛素化胞内蛋白的降解。编码的蛋白质是 26S 蛋白酶体的 19S 调节帽复合物的组分，并介导底物去泛素化。该基因的假基因也位于 2 号染色体的长臂上。[RefSeq 提供，2012 年 2 月]

This gene encodes a component of the 26S Proteasome. The 26S Proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S Proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012]

PSMD14 基因产物(1)

mRNA Protein Name
NM_005805.6 NP_005796.1 26S proteasome non-ATPase regulatory subunit 14
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables endopeptidase activator activity IMP
IMP: 通过突变表型推断
18162577 GOA
enables metal-dependent deubiquitinase activity IMP
IMP: 通过突变表型推断
22909820 GOA
enables proteasome binding IDA
IDA: 通过直接分析推断
18162577 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19615732 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in double-strand break repair via homologous recombination IMP
IMP: 通过突变表型推断
22909820 GOA
involved in double-strand break repair via nonhomologous end joining IMP
IMP: 通过突变表型推断
22909820 GOA
involved in protein K63-linked deubiquitination IMP
IMP: 通过突变表型推断
22909820 GOA
involved in regulation of proteasomal protein catabolic process IMP
IMP: 通过突变表型推断
18162577 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of proteasome complex IDA
IDA: 通过直接分析推断
17323924 GOA
part of proteasome regulatory particle, lid subcomplex IMP
IMP: 通过突变表型推断
22909820 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PSMD14 蛋白结构

JAB

JAB: JAB1/Mov34/MPN/PAD-1 ubiquitin protease (28 - 138)

MitMem_reg

MitMem_reg: Maintenance of mitochondrial structure and function (173 - 295)

  • 0
  • 100
  • 200
  • 310 a.a.
蛋白主名 其他名称

26S proteasome non-ATPase regulatory subunit 14

26S proteasome regulatory subunit rpn11

PSMD14 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PSMD14 O00487 FAM9B Homo sapiens Q8IZU0
Y2H Prey Pooling
25416956
种属内
PSMD14 O00487 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25416956
种属内
PSMD14 O00487 PSMD7 Homo sapiens P51665
Y2H Prey Pooling
25416956
种属内
PSMD14 O00487 PSMD7 Homo sapiens P51665
Y2H Prey Pooling
32296183
种属内
PSMD14 O00487 PSMD7 Homo sapiens P51665
Y2H Array
25416956
种属内
PSMD14 O00487 PSMD7 Homo sapiens P51665
Y2H Array
32296183
种属内
PSMD14 O00487 PSMD7 Homo sapiens P51665
Validated Y2H
25416956
种属内
PSMD14 O00487 PSMD7 Homo sapiens P51665
Anti Tag CoIP
26496610
种属内
PSMD14 O00487 PSMD7 Homo sapiens P51665
Anti Tag CoIP
19615732
种属内
PSMD14 O00487 PSMD7 Homo sapiens P51665
Validated Y2H
32296183
种属内
PSMD14 O00487 HTT Homo sapiens P42858
Validated Y2H
32814053
种属内
PSMD14 O00487 HTT Homo sapiens P42858
Y2H Pooling
32814053
种属内
PSMD14 O00487 HTT Homo sapiens P42858
Y2H Array
32814053
种属内
PSMD14 O00487 DPY30 Homo sapiens Q9C005
Validated Y2H
32296183
种属内
PSMD14 O00487 DPY30 Homo sapiens Q9C005
Y2H Array
25416956
种属内
PSMD14 O00487 MEOX2 Homo sapiens P50222
Y2H Array
25416956
种属内
PSMD14 O00487 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

PSMD14 抗体

目录号 产品名 应用 反应物种
HY-P82505 PSMD14 Antibody (YA2250) WB, IHC-P, ICC/IF Human, Mouse, Rat

关联疾病

疾病名称 别名
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Angelman Syndrome

AS

Happy Puppet Syndrome

Happy Puppet Syndrome, Formerly

Puppetlike Syndrome
Machado-Joseph Disease

SCA3

MJD

Spinocerebellar Ataxia 3

Azorean Disease

Spinocerebellar Ataxia Type 3

Spinocerebellar Atrophy

Azorean Neurologic Disease

Spinopontine Atrophy

Nigrospinodentatal Degeneration

Spinocerebellar Atrophy Iii

Spinocerebellar Atrophy Type 3

Azorean Ataxia

Azorean Disease Of The Nervous System

Machado Disease

Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

Disease, Machado-Joseph

Ataxia, Spinocerebellar
Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11322 PSMD14 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PSMD14 MGD MGI:1913284
Rattus norvegicus PSMD14 RGD RGD:1594532
Canis familiaris PSMD14 VGNC VGNC:45110
Felis catus PSMD14 VGNC VGNC:64415
Bos taurus PSMD14 VGNC VGNC:33465
Macaca mulatta PSMD14 VGNC VGNC:76269
Others PSMD14 NCBI
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