2. Gene
  3. ZFYVE19 - zinc finger FYVE-type containing 19 Gene

ZFYVE19 - zinc finger FYVE-type containing 19 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含锌指 FYVE 型 19

种属: Homo sapiens

同用名: ANCHR; PFIC9; MPFYVE

基因 ID: 84936 | 基因类型: protein coding

关于 ZFYVE19

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,807,089-40,815,084 (from NCBI)

This gene has 16 transcripts (splice variants), 193 orthologues, 13 paralogues and is associated with 2 phenotypes. Ubiquitous expression in duodenum (RPKM 6.2), small intestine (RPKM 6.1) and 25 other tissues.

功能概要

启用磷脂酰肌醇-3-磷酸结合活性。参与离职；有丝分裂胞质分裂检查点信号；和胞质分裂的负调节。位于中心体；卵裂沟;和中体。 [由基因组资源联盟提供，2022 年 4 月]

Enables phosphatidylinositol-3-phosphate binding activity. Involved in abscission; mitotic cytokinesis checkpoint signaling; and negative regulation of cytokinesis. Located in centrosome; cleavage furrow; and midbody. [provided by Alliance of Genome Resources, Apr 2022]

ZFYVE19 基因产物(4)

mRNA Protein Name
NM_001077268.2 NP_001070736.1 abscission/NoCut checkpoint regulator isoform 1
NM_001258420.2 NP_001245349.1 abscission/NoCut checkpoint regulator isoform 2
NM_001258421.2 NP_001245350.1 abscission/NoCut checkpoint regulator isoform 4
NM_032850.5 NP_116239.3 abscission/NoCut checkpoint regulator isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatidylinositol-3-phosphate binding IDA
IDA: 通过直接分析推断
24814515 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17500595 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in abscission IMP
IMP: 通过突变表型推断
24814515 GOA
involved in mitotic cytokinesis checkpoint signaling IMP
IMP: 通过突变表型推断
24814515 GOA
involved in negative regulation of cytokinesis IMP
IMP: 通过突变表型推断
24814515 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
24814515 GOA
located in cleavage furrow IDA
IDA: 通过直接分析推断
24814515 GOA
located in midbody IDA
IDA: 通过直接分析推断
24814515 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZFYVE19 蛋白结构

FYVE

FYVE: FYVE zinc finger (78 - 133)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 471 a.a.
蛋白主名 其他名称

abscission/NoCut checkpoint regulator

MLL partner containing FYVE domain

ZFYVE19 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZFYVE19 Q96K21 CAPN7 Homo sapiens Q7Z479
Y2H Prey Pooling
25416956
种属内
ZFYVE19 Q96K21 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
种属内
ZFYVE19 Q96K21 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
种属内
ZFYVE19 Q96K21 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
种属内
ZFYVE19 Q96K21 VPS4B Homo sapiens O75351
Y2H Array
31515488
种属内
ZFYVE19 Q96K21 VPS4B Homo sapiens O75351
Validated Y2H
25416956
种属内
ZFYVE19 Q96K21 VPS4B Homo sapiens O75351
Y2H Array
25416956
种属内
ZFYVE19 Q96K21 VPS4B Homo sapiens O75351
Y2H Prey Pooling
25416956
种属内
ZFYVE19 Q96K21 MITD1 Homo sapiens Q8WV92
Y2H Prey Pooling
25416956
种属内
ZFYVE19 Q96K21 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
种属内
ZFYVE19 Q96K21 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
种属内
ZFYVE19 Q96K21 HSPB1 Homo sapiens P04792
Y2H Array
32814053
种属内
ZFYVE19 Q96K21 HTT Homo sapiens P42858
Y2H
17500595
种属内
ZFYVE19 Q96K21 DPY30 Homo sapiens Q9C005
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cholestasis, Progressive Familial Intrahepatic, 9

PFIC9
Ileocolitis

Iieocolitis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16057 ZFYVE19 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus ZFYVE19 VGNC VGNC:67239
Macaca mulatta ZFYVE19 VGNC VGNC:99348
Bos taurus ZFYVE19 VGNC VGNC:37175
Rattus norvegicus ZFYVE19 RGD RGD:1561576
Mus musculus ZFYVE19 MGD MGI:1919258
Canis familiaris ZFYVE19 VGNC VGNC:48624
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