2. Gene
  3. VPS4B - vacuolar protein sorting 4 homolog B Gene

VPS4B - vacuolar protein sorting 4 homolog B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：液泡蛋白分选 4 同系物 B

种属: Homo sapiens

同用名: MIG1; SKD1; SKD1B; VPS4-2

基因 ID: 9525 | 基因类型: protein coding

关于 VPS4B

Cytogenetic location: 18q21.33 Genomic coordinates (GRCh38): 18:63,389,190-63,422,476 (from NCBI)

This gene has 7 transcripts (splice variants), 263 orthologues, 9 paralogues and is associated with 1 phenotype. Ubiquitous expression in esophagus (RPKM 35.7), colon (RPKM 23.8) and 25 other tissues.

功能概要

该基因编码的蛋白质是 AAA 蛋白家族 (与多种细胞活动相关的 ATP 酶) 的成员，并且是酵母 Vps4 蛋白的同系物。在人类中，已经鉴定出酵母蛋白的两个旁系同源物。前者彼此之间以及与酵母 Vps4 和小鼠 Skd1 蛋白之间具有高度的 aa 序列相似性。小鼠 Skd1 (K+ 转运缺陷 1 的抑制因子) 已被证明是酵母 Vps4 直系同源物。功能研究表明，两种人类旁系同源物都与内体区室相关，并参与细胞内蛋白质运输，类似于酵母中的 Vps4 蛋白质。编码该旁系同源物的基因已定位于 18 号染色体；另一个基因位于 16 号染色体上。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each Other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the Other resides on chromosome 16. [provided by RefSeq, Jul 2008]

VPS4B 基因产物(1)

mRNA Protein Name
NM_004869.4 NP_004860.2 vacuolar protein sorting-associated protein 4B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP hydrolysis activity IDA
IDA: 通过直接分析推断
11563910 GOA
enables identical protein binding IDA
IDA: 通过直接分析推断
16193069 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11563910 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
16193069 GOA
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
18687924 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ESCRT III complex disassembly IDA
IDA: 通过直接分析推断
18687924 GOA
acts upstream of or within endosomal transport IDA
IDA: 通过直接分析推断
11563910 GOA
involved in endosome to lysosome transport via multivesicular body sorting pathway IMP
IMP: 通过突变表型推断
15024011 GOA
involved in midbody abscission IMP
IMP: 通过突变表型推断
20616062 GOA
involved in mitotic metaphase chromosome alignment IMP
IMP: 通过突变表型推断
20616062 GOA
involved in negative regulation of exosomal secretion IMP
IMP: 通过突变表型推断
24105262 GOA
involved in nucleus organization IMP
IMP: 通过突变表型推断
20616062 GOA
involved in positive regulation of G2/M transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
20616062 GOA
involved in positive regulation of centriole elongation IMP
IMP: 通过突变表型推断
20616062 GOA
involved in positive regulation of exosomal secretion IMP
IMP: 通过突变表型推断
22660413 GOA
involved in protein depolymerization IDA
IDA: 通过直接分析推断
18687924 GOA
involved in regulation of centrosome duplication IMP
IMP: 通过突变表型推断
20616062 GOA
involved in regulation of mitotic spindle assembly IMP
IMP: 通过突变表型推断
20616062 GOA
involved in response to lipid IDA
IDA: 通过直接分析推断
16757520 GOA
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
IMP: 通过突变表型推断
22547407 GOA
involved in ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway IMP
IMP: 通过突变表型推断
22547407 GOA
involved in viral budding from plasma membrane IMP
IMP: 通过突变表型推断
14505570 GOA
involved in viral budding via host ESCRT complex IGI
IGI: 通过遗传相互作用推断
24107264 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Flemming body IDA
IDA: 通过直接分析推断
20616062 GOA
located in centrosome IDA
IDA: 通过直接分析推断
20616062 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
16757520 GOA
located in endosome IDA
IDA: 通过直接分析推断
11563910 GOA
located in endosome membrane IDA
IDA: 通过直接分析推断
16757520 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16757520 GOA
located in spindle pole IDA
IDA: 通过直接分析推断
20616062 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VPS4B 蛋白结构

MIT

MIT: MIT (microtubule interacting and transport) domain (8 - 76)

AAA

AAA: ATPase family associated with various cellular activities (AAA) (170 - 300)

Vps4_C

Vps4_C: Vps4 C terminal oligomerisation domain (381 - 441)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 444 a.a.
蛋白主名 其他名称

vacuolar protein sorting-associated protein 4B

cell migration-inducing 1

VPS4B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra VPS4B O75351 ZFYVE19 Homo sapiens Q96K21-3
Y2H Array
25416956
Intra VPS4B O75351 CHMP1A Homo sapiens Q9HD42
Validated Y2H
32296183
Intra VPS4B O75351 CHMP1A Homo sapiens Q9HD42
Y2H Prey Pooling
32296183
Intra VPS4B O75351 CHMP1A Homo sapiens Q9HD42
Y2H Array
32296183
Intra VPS4B O75351 CHMP2B Homo sapiens Q9UQN3-1
NMR
17928862
Intra VPS4B O75351 CHMP2B Homo sapiens Q9UQN3-1
SPR
17928862
Intra VPS4B O75351 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra VPS4B O75351 HTT Homo sapiens P42858
Y2H Array
32814053
Intra VPS4B O75351 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra VPS4B O75351 ZFYVE19 Homo sapiens Q96K21
Validated Y2H
32296183
Intra VPS4B O75351 ZFYVE19 Homo sapiens Q96K21
Y2H Array
32296183
Intra VPS4B O75351 ZFYVE19 Homo sapiens Q96K21
Y2H Prey Pooling
32296183
Intra VPS4B O75351 KATNAL1 Homo sapiens Q9BW62
Y2H Prey Pooling
32296183
Intra VPS4B O75351 KATNAL1 Homo sapiens Q9BW62
Validated Y2H
32296183
Intra VPS4B O75351 KATNAL1 Homo sapiens Q9BW62
Y2H Array
32296183
Intra VPS4B O75351 CHMP5 Homo sapiens Q9NZZ3
Validated Y2H
25416956
Intra VPS4B O75351 CHMP5 Homo sapiens Q9NZZ3
Y2H Prey Pooling
32296183
Intra VPS4B O75351 CHMP5 Homo sapiens Q9NZZ3
Y2H Array
32296183
Intra VPS4B O75351 CHMP5 Homo sapiens Q9NZZ3
Validated Y2H
32296183
Intra VPS4B O75351 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Intra VPS4B O75351 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Intra VPS4B O75351 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Dentin Dysplasia, Type I

Radicular Dentin Dysplasia

DTDP1

Rootless Teeth

Dentin Dysplasia Type I

Dd-I

Dentin Dysplasia Shields Type I

Dentin Dysplasia, Shields Type I

Dentin Dysplasia, Type I, With Microdontia And Misshapen Teeth

Dentin Dysplasia, Type 1

Atypical Dentin Dysplasia Due To Smoc2 Deficiency

Dentin Dysplasia Type 1 With Microdontia And Shape Anomalies

Dentin Dysplasia, Radicular

Dentin Dysplasia 1

Dentin Dysplasia 1, With Extreme Microdontia And Misshapen Teeth

DTDP1-MMT

Dentin Dysplasia, Type I, With Extreme Microdontia And Misshapen Teeth

Dysplasia, Dentin, Type I
Dentin Dysplasia

Dentinal Dysplasia

Dd

Dysplasia, Dentin

Shell Teeth
Meckel Syndrome, Type 6

Meckel Syndrome 6

MKS6

Meckel-Gruber Syndrome, Type 6
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-123872 MSC1094308 Inhibitor 99.89% 否
HY-RS15694 VPS4B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus VPS4B RGD RGD:1305969
Bos taurus VPS4B VGNC VGNC:36825
Canis familiaris VPS4B VGNC VGNC:48293
Felis catus VPS4B VGNC VGNC:66970
Mus musculus VPS4B MGD MGI:1100499
Macaca mulatta VPS4B VGNC VGNC:78555
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