TAF1C - TATA-box binding protein associated factor, RNA polymerase I subunit C Gene

中文名称：TATA-box 结合蛋白相关因子，RNA 聚合酶 I 亚基 C

种属: Homo sapiens

同用名: SL1; TAFI95; TAFI110; MGC:39976

关于 TAF1C

功能概要

RNA 聚合酶 I 启动转录需要形成一个复合物，该复合物由 TATA 结合蛋白 (TBP) 和三个特异于 RNA 聚合酶 I 的 TBP 相关因子 (TAF) 组成。该复合物称为 SL1，与核心启动子结合核糖体 RNA 基因正确定位聚合酶并充当调节信号的通道。该基因编码最大的 SL1 特异性 TAF。已经鉴定出编码不同同种型的多个选择性剪接的转录物变体。[RefSeq 提供，2011 年 7 月]

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]