1. Gene
  2. SET - SET nuclear proto-oncogene Gene

SET - SET nuclear proto-oncogene Gene

中文名称:SET 核原癌基因

种属: Homo sapiens

同用名: 2PP2A; IGAAD; MRD58; TAF-I; I2PP2A; IPP2A2; PHAPII; TAF-IBETA

基因 ID: 6418 | 基因类型: protein coding

关于 SET

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:128,683,424-128,696,396 (from NCBI)

This gene has 14 transcripts (splice variants), 285 orthologues, 18 paralogues and is associated with 50 phenotypes. Ubiquitous expression in lymph node (RPKM 55.8), appendix (RPKM 46.5) and 25 other tissues.

功能概要

该基因编码的蛋白质通过组蛋白乙酰化酶 (HAT) 抑制核小体的乙酰化,尤其是组蛋白 H4。这种抑制很可能是通过掩盖组蛋白赖氨酸不被乙酰化来实现的,其结果是使 HAT 依赖性转录沉默。编码的蛋白质是定位于内质网的复合物的一部分,但存在于细胞核中,可抑制细胞毒性 T 淋巴细胞攻击后的细胞凋亡。这种蛋白质还可以增强腺病毒基因组的 DNA 复制。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供,2011 年 10 月]

The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits Apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

SET 基因产物(5)

mRNA Protein Name
NM_001122821.2 NP_001116293.1 protein SET isoform 1
NM_001248000.2 NP_001234929.1 protein SET isoform 3
NM_001248001.2 NP_001234930.1 protein SET isoform 4
NM_001374326.1 NP_001361255.1 protein SET isoform 1
NM_003011.4 NP_003002.2 protein SET isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11909973 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
19343227 GOA
acts upstream of or within negative regulation of neuron apoptotic process IGI
IGI: 通过遗传相互作用推断
18374643 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11909973 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
11555662 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11555662 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
11555662 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
11909973 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SET 蛋白结构

NAP

NAP: Nucleosome assembly protein (NAP) (43 - 235)

  • 0
  • 100
  • 200
  • 290 a.a.
蛋白主名 其他名称

protein SET

HLA-DR-associated protein II

SET 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SET Q01105 FOXO1 Homo sapiens Q12778 24983498
种属内
SET Q01105 FOXO1 Homo sapiens Q12778 24983498
种属内
SET Q01105 FOXO1 Homo sapiens Q12778 24983498
种属内
SET Q01105 TAF1B Homo sapiens Q53T94 17318177
种属内
SET Q01105 TAF1C Homo sapiens Q15572 17318177
种属内
SET Q01105 TBP Homo sapiens P20226 17318177
种属内
SET Q01105 MDM2 Homo sapiens Q00987 20195357
种属内
SET Q01105 UBTF Homo sapiens P17480 17318177
种属内
SET Q01105 RAC1 Homo sapiens P63000 17245428
种属内
SET Q01105 RAC1 Homo sapiens P63000 17245428
种属内
SET Q01105 PRKAR1A Homo sapiens P10644
TAP
20195357
种属内
SET Q01105 FAM111B Homo sapiens Q6SJ93 33961781
种属内
SET Q01105 SDCBP Homo sapiens O00560 25416956
种属内
SET Q01105 SDCBP Homo sapiens O00560 25416956
种属内
SET Q01105 SDCBP Homo sapiens O00560 25416956
种属内
SET Q01105 THAP7 Homo sapiens Q9BT49 31515488
种属内
SET Q01105 THAP7 Homo sapiens Q9BT49 25416956
种属内
SET Q01105 THAP7 Homo sapiens Q9BT49 25416956
种属内
SET Q01105 THAP7 Homo sapiens Q9BT49 21988832
种属内
SET Q01105 THAP7 Homo sapiens Q9BT49 16189514
种属内
SET Q01105 THAP7 Homo sapiens Q9BT49
Y2H
21988832
种属内
SET Q01105 MEOX2 Homo sapiens P50222 25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

SET 抗体

目录号 产品名 应用 反应物种
HY-P82190 SET Antibody (YA1935) WB, IHC-F, IHC-P, ICC/IF, IP Human

关联疾病

疾病名称 别名
Intellectual Developmental Disorder, Autosomal Dominant 58

Mental Retardation, Autosomal Dominant 58

MRD58

Precursor T-Cell Acute Lymphoblastic Leukemia

T-All

Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma

Precursor T-Cell Acute Lymphocytic Leukemia

Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Adult T-Cell Lymphoma/Leukemia

Autosomal Dominant Non-Syndromic Intellectual Disability
Acute Biphenotypic Leukemia

Mixed Phenotype Acute Leukemia

Acute Leukemia Of Ambiguous Lineage

Acute Undifferentiated Leukemia

Acute Leukemia Of Indeterminate Lineage

Hybrid Acute Leukemia

Mixed Lineage Acute Leukemia

All With Myeloid Markers

Aml With Lymphoid Markers

Acute Leukemia Of Undetermined Lineage

Bal

Biphenotypic Acute Leukemia

Undifferentiated Acute Leukemia

Mpal

Acute Myeloid Leukemia, Minimal Differentiation, Fab M0

Leukemia, Biphenotypic, Acute

Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus SET MGD MGI:1860267
Rattus norvegicus SET RGD RGD:41368318
Macaca fascicularis SET NCBI NCBI:102118249
Macaca mulatta SET NCBI NCBI:693242
Others SET NCBI