2. Gene
  3. AKAP5 - A-kinase anchoring protein 5 Gene

AKAP5 - A-kinase anchoring protein 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：A-激酶锚定蛋白 5

种属: Homo sapiens

同用名: H21; AKAP75; AKAP79

基因 ID: 9495 | 基因类型: protein coding

关于 AKAP5

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:64,465,499-64,474,503 (from NCBI)

This gene has 2 transcripts (splice variants) and 105 orthologues. Biased expression in brain (RPKM 10.3), colon (RPKM 3.6) and 10 other tissues.

功能概要

激酶锚定蛋白 (AKAP) 是一组结构多样的蛋白质，它们具有与蛋白激酶 A (PKA) 的调节亚基结合并将全酶限制在细胞内离散位置的共同功能。该基因编码 AKAP 家族的一个成员。编码的蛋白质与 PKA 的 RII-β 调节亚基结合，也与蛋白激酶 C 和磷酸酶钙调神经磷酸酶结合。它主要在大脑皮层中表达，并可能将 PKA 蛋白锚定在突触后密度 (PSD) 并参与突触后事件的调节。它也在 T 淋巴细胞中表达，并可能通过破坏 NFAT 的神经钙蛋白依赖性去磷酸化来抑制白细胞介素 2 的转录。[RefSeq 提供，2008 年 7 月]

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase Calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008]

AKAP5 基因产物(1)

mRNA Protein Name
NM_004857.3 NP_004848.3 A-kinase anchor protein 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SH3 domain binding IPI
IPI: 通过物理相互作用推断
10939335 GOA
enables adenylate cyclase binding IPI
IPI: 通过物理相互作用推断
17081159 GOA
enables calmodulin binding EXP
EXP: 通过实验结果推断
35697294 GOA
enables glutamate receptor binding IDA
IDA: 通过直接分析推断
10939335 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11287423 GOA
enables protein kinase A regulatory subunit binding IDA
IDA: 通过直接分析推断
21502359 GOA
enables protein kinase A regulatory subunit binding IPI
IPI: 通过物理相互作用推断
17911601 GOA
enables protein phosphatase 2B binding IDA
IDA: 通过直接分析推断
10939335 GOA
enables scaffold protein binding IPI
IPI: 通过物理相互作用推断
10939335 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
17081159 GOA
involved in calcineurin-NFAT signaling cascade IMP
IMP: 通过突变表型推断
33941685 GOA
involved in negative regulation of adenylate cyclase activity IMP
IMP: 通过突变表型推断
20410303 GOA
involved in positive regulation of endosome to plasma membrane protein transport IMP
IMP: 通过突变表型推断
25589740 GOA
involved in positive regulation of long-term synaptic potentiation IMP
IMP: 通过突变表型推断
25589740 GOA
involved in positive regulation of protein localization to plasma membrane IMP
IMP: 通过突变表型推断
22343722 GOA
involved in regulation of protein kinase A signaling IMP
IMP: 通过突变表型推断
17081159 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic side of plasma membrane IDA
IDA: 通过直接分析推断
22343722 GOA
located in membrane raft IMP
IMP: 通过突变表型推断
21771783 GOA
located in postsynaptic recycling endosome IDA
IDA: 通过直接分析推断
25589740 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AKAP5 蛋白结构

WSK

WSK: WSK motif (74 - 102)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 427 a.a.
蛋白主名 其他名称

A-kinase anchor protein 5

A kinase (PRKA) anchor protein 5

AKAP5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
AKAP5 P24588 PPP3CA Homo sapiens Q08209-2
Validated Y2H
32296183
种属内
AKAP5 P24588 ROPN1 Homo sapiens Q9HAT0
Validated Y2H
32296183
种属内
AKAP5 P24588 PPP3CA Homo sapiens Q08209-1
GMS
22343722
种属内
AKAP5 P24588 PPP3CA Homo sapiens Q08209-1
Light Scattering
22343722
种属内
AKAP5 P24588 PPP3CA Homo sapiens Q08209-1
X-Ray Diffraction
22343722
种属内
AKAP5 P24588 PRKAR2A Homo sapiens P13861
Filter Binding
16642035
种属内
AKAP5 P24588 PRKAR2A Homo sapiens P13861
GMS
22343722
种属内
AKAP5 P24588 PRKAR2A Homo sapiens P13861
Anti Tag CoIP
26496610
种属内
AKAP5 P24588 PRKAR2A Homo sapiens P13861
FRET
22343722
种属内
AKAP5 P24588 PRKAR2B Homo sapiens P31323
Validated Y2H
32296183
种属间
AKAP5 P24588 Kcnj2 Mus musculus P35561
Pull Down
11287423
种属内
AKAP5 P24588 RXFP1 Homo sapiens Q9HBX9
Pull Down
20664520
种属内
AKAP5 P24588 ROPN1L Homo sapiens Q96C74
Validated Y2H
32296183
种属内
AKAP5 P24588 ROPN1L Homo sapiens Q96C74
Y2H Prey Pooling
32296183
种属内
AKAP5 P24588 ROPN1L Homo sapiens Q96C74
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Fleck Retina, Familial Benign

FRFB

Familial Benign Flecked Retina

Familial Benign Fleck Retina
Retinitis Pigmentosa 18

RP18

Retinitis Pigmentosa-18

Retinitis Pigmentosa, Type 18
Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

X-Linked Intellectual Disability And Macroorchidism

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00520 AKAP5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus AKAP5 VGNC VGNC:25786
Mus musculus AKAP5 MGD MGI:2685104
Macaca mulatta AKAP5 VGNC VGNC:84299
Rattus norvegicus AKAP5 RGD RGD:620829
Felis catus AKAP5 VGNC VGNC:59715
Canis familiaris AKAP5 VGNC VGNC:37758
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