2. Gene
  3. ODF1 - outer dense fiber of sperm tails 1 Gene

ODF1 - outer dense fiber of sperm tails 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：精子尾部外层致密纤维 1

种属: Homo sapiens

同用名: ODF; RT7; ODF2; ODFP; SODF; CT133; ODF27; ODFPG; HSPB10; ODFPGA; ODFPGB

基因 ID: 4956 | 基因类型: protein coding

关于 ODF1

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:102,551,589-102,561,018 (from NCBI)

This gene has 2 transcripts (splice variants) and 107 orthologues. Restricted expression toward testis (RPKM 125.7).

功能概要

外部致密纤维是细胞骨架结构，围绕着精子尾部中间部分和主要部分的轴丝。纤维的作用是维持精子尾部的弹性结构和反冲，以及在附睾运输和射精过程中保护尾部免受剪切力的影响。外部致密纤维的缺陷会导致精子形态异常和不育。人体外层致密纤维至少含有 10 种主要蛋白质，该基因编码主要蛋白质。[RefSeq 提供，2008 年 7 月]

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. The human outer dense fibers contains at least 10 major proteins and this gene encodes the main protein. [provided by RefSeq, Jul 2008]

ODF1 基因产物(1)

mRNA Protein Name
NM_024410.4 NP_077721.2 outer dense fiber protein 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21597245 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ODF1 蛋白结构

HSP20

HSP20: Hsp20/alpha crystallin family (129 - 190)

  • 0
  • 100
  • 200
  • 250 a.a.
蛋白主名 其他名称

outer dense fiber protein 1

cancer/testis antigen 133

ODF1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ODF1 Q14990 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
25416956
种属内
ODF1 Q14990 LCE1C Homo sapiens Q5T751
Y2H Prey Pooling
32296183
种属内
ODF1 Q14990 LCE1C Homo sapiens Q5T751
Y2H Array
32296183
种属内
ODF1 Q14990 LCE1C Homo sapiens Q5T751
Validated Y2H
32296183
种属内
ODF1 Q14990 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
ODF1 Q14990 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
ODF1 Q14990 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
种属内
ODF1 Q14990 P4HB Homo sapiens P07237
Y2H Array
32296183
种属内
ODF1 Q14990 P4HB Homo sapiens P07237
Y2H Prey Pooling
32296183
种属内
ODF1 Q14990 MDFI Homo sapiens Q99750
Validated Y2H
32296183
种属内
ODF1 Q14990 MDFI Homo sapiens Q99750
Y2H Array
32296183
种属内
ODF1 Q14990 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
种属内
ODF1 Q14990 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
种属内
ODF1 Q14990 HOXA1 Homo sapiens P49639
Y2H Array
32296183
种属内
ODF1 Q14990 MTUS2 Homo sapiens Q5JR59
Validated Y2H
25416956
种属内
ODF1 Q14990 KRT86 Homo sapiens O43790
Y2H Prey Pooling
32296183
种属内
ODF1 Q14990 KRT86 Homo sapiens O43790
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Neuronopathy, Distal Hereditary Motor, Type Iic

HMN2C

Hmn Iic

Dhmn2c

Distal Hereditary Motor Neuronopathy Type 2c

Distal Hereditary Motor Neuropathy Type Iic

Neuronopathy, Distal Hereditary Motor, Type 2c

Neuropathy, Distal Hereditary Motor, Type Iic

Neuronopathy, Distal Hereditary Motor, 2c

Dhmn Iic

Neuropathy, Motor, Distal, Hereditary, Type 2c
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Infertility
Spermatogenic Failure 16

SPGF16

Acephalic Spermatozoa Syndrome

Spermatozoa, Acephalic
Male Infertility Due To Acephalic Spermatozoa

Acephalic Spermatozoa Syndrome
Distal Hereditary Motor Neuronopathy Type 2

Distal Hereditary Motor Neuropathy, Type Ii

Distal Hereditary Motor Neuropathy Type 2

Distal Hereditary Motor Neuropathy Type Ii

Hmn Ii

Hmn2

Distal Hereditary Motor Neuronopathy, Type Ii

Distal Spinal Muscular Atrophy Type 2

Dhmn2

Dsma2

Neuropathy, Motor, Distal, Hereditary, Type Ii

Spinal Muscular Atrophy, Jerash Type
Spermatogenic Failure 9

Male Infertility Due To Globozoospermia

SPGF9

Male Infertility Due To Round-Headed Spermatozoa

Globozoospermia, Complete

Globozoospermia, Total

Globozoospermia

Globozoospermia Syndrome

Round-Headed Sperm Syndrome

Globozoospermia Complete

Globozoospermia Total
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09751 ODF1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ODF1 RGD RGD:3228
Bos taurus ODF1 VGNC VGNC:32400
Mus musculus ODF1 MGD MGI:97424
Macaca mulatta ODF1 VGNC VGNC:75579
Canis familiaris ODF1 VGNC VGNC:44098
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