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  2. CASP2 - caspase 2 Gene

CASP2 - caspase 2 Gene

中文名称:半胱天冬酶 2

种属: Homo sapiens

同用名: ICH1; NEDD2; CASP-2; NEDD-2; PPP1R57

基因 ID: 835 | 基因类型: protein coding

关于 CASP2

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:143,288,351-143,307,696 (from NCBI)

This gene has 7 transcripts (splice variants), 215 orthologues, 16 paralogues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 14.7), lymph node (RPKM 11.6) and 25 other tissues.

功能概要

该基因编码半胱氨酸-天冬氨酸蛋白酶 (半胱天冬酶) 家族的成员。 Caspases 通过特定蛋白质底物的蛋白水解裂解来介导细胞凋亡。编码的蛋白质可能在应激诱导的细胞死亡途径、细胞周期维持和肿瘤发生抑制中发挥作用。该基因表达增加可能在神经退行性疾病中发挥作用,包括阿尔茨海默病、亨廷顿舞蹈病和颞叶癫痫。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供,2011 年 1 月]

This gene encodes a member of the cysteine-aspartic acid protease (Caspase) family. Caspases mediate cellular Apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

CASP2 基因产物(4)

mRNA Protein Name
NM_032982.4 NP_116764.2 caspase-2 isoform 1 preproprotein
NM_032984.2
NM_001224.5 NP_001215.1 caspase-2 isoform 2
NM_032983.4 NP_116765.2 caspase-2 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type endopeptidase activity IDA
IDA: 通过直接分析推断
9044836 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
22531785 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
8985253 GOA
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
9044836 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP
IMP: 通过突变表型推断
21726810 GOA
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
19593445 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
10980123 GOA
involved in protein processing IDA
IDA: 通过直接分析推断
9044836 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of endopeptidase complex IPI
IPI: 通过物理相互作用推断
15073321 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CASP2 蛋白结构

CARD

CARD: Caspase recruitment domain (37 - 118)

Peptidase_C14

Peptidase_C14: Caspase domain (201 - 442)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 452 a.a.
蛋白主名 其他名称

caspase-2

caspase 2 apoptosis-related cysteine peptidase

neural precursor cell expressed developmentally down-regulated protein 2

protease ICH-1

protein phosphatase 1, regulatory subunit 57

CASP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CASP2 P42575 BAG4 Homo sapiens O95429 32296183
种属内
CASP2 P42575 BAG4 Homo sapiens O95429 32296183
种属内
CASP2 P42575 CRADD Homo sapiens P78560 25416956
种属内
CASP2 P42575 CRADD Homo sapiens P78560 15073321
种属内
CASP2 P42575 CRADD Homo sapiens P78560 8985253
种属内
CASP2 P42575 CRADD Homo sapiens P78560 32296183
种属内
CASP2 P42575 CRADD Homo sapiens P78560 25416956
种属内
CASP2 P42575 CRADD Homo sapiens P78560 16652156
种属内
CASP2 P42575 CRADD Homo sapiens P78560 31467278
种属内
CASP2 P42575 CRADD Homo sapiens P78560 37398436
种属内
CASP2 P42575 CRADD Homo sapiens P78560 31467278
种属内
CASP2 P42575 CRADD Homo sapiens P78560 27107012
种属内
CASP2 P42575 CRADD Homo sapiens P78560 31467278
种属内
CASP2 P42575 CRADD Homo sapiens P78560 37398436
种属内
CASP2 P42575 CRADD Homo sapiens P78560 15073321
种属内
CASP2 P42575 CRADD Homo sapiens P78560 25416956
种属内
CASP2 P42575 CASP2 Homo sapiens P42575-1 11156409
种属间: 跨种属相互作用 种属内: 同种属相互作用

CASP2 抗体

目录号 产品名 应用 反应物种
HY-P83027 Cleaved-Caspase 2 Antibody (YA2772) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Epilepsy

Epilepsy Syndrome

Epileptic Syndrome

Epilepsies

Symptomatic Epilepsies

Post Traumatic Epilepsy

Traumatic Epilepsy

Traumatic Epileptic

Epilepsy Due To Hippocampal Sclerosis

Epilepsy With Ammon'S Horn Sclerosis

Epilepsy Due To Cortical Dysplasia

Epilepsy Due To Neuronal Migration Disorders

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Lung Cancer Susceptibility 3

Lung Adenocarcinoma

Adenocarcinoma Of Lung

LNCR3

Adenocarcinoma Of Lung, Susceptibility To

Bronchogenic Lung Adenocarcinoma

Nonsmall Cell Adenocarcinoma

Adenocarcinoma Lung

Lung Adenocarcinomas

Non-Small Cell Adenocarcinoma

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Temporal Lobe Epilepsy

Epilepsy, Temporal Lobe

Epilepsy Temporal Lobe

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Lissencephaly

Pachygyria

Broad Gyri Of Cerebrum

Large Gyri Of Cerebrum

Macrogyria

Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma

Nonarteritic Anterior Ischemic Optic Neuropathy

Anterior Ischemic Optic Neuropathy

Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility To

NAION

Non-Arteritic Anterior Ischemic Optic Neuropathy

Ischemic Optic Neuropathy

Aion

Optic Neuropathy, Ischemic

Naion, Susceptibility To

Optic Neuropathy, Anterior Ischemic

Optic Neuropathy, Anterior Ischemic, Susceptibility To

Non-Arteritic Anterior Ischaemic Optic Neuropathy

Nonarteritic Anterior Ischaemic Optic Neuropathy

Neuropathy, Optic, Ischemic, Nonarteritic Anterior, Susceptibility To

Ion - [Ischemic Optic Neuropathy]

Neuropathic Ischaemia Of N.Opticus

Ischaemic Neuropathy Of Optic Nerve

Bladder Transitional Cell Papilloma

Bladder Papilloma

Transitional Cell Papilloma Of Bladder

Urinary Bladder Urothelial Papilloma

Urothelial Papilloma

Bladder Urothelial Papilloma

Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus CASP2 VGNC VGNC:60381
Macaca mulatta CASP2 VGNC VGNC:80804
Bos taurus CASP2 VGNC VGNC:26780
Canis familiaris CASP2 VGNC VGNC:38733
Rattus norvegicus CASP2 RGD RGD:69274
Mus musculus CASP2 MGD MGI:97295