2. Gene
  3. BTG1 - BTG anti-proliferation factor 1 Gene

BTG1 - BTG anti-proliferation factor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：BTG 抗增殖因子 1

种属: Homo sapiens

同用名: APRO2

基因 ID: 694 | 基因类型: protein coding

关于 BTG1

Cytogenetic location: 12q21.33 Genomic coordinates (GRCh38): 12:92,140,278-92,145,846 (from NCBI)

This gene has 3 transcripts (splice variants), 224 orthologues, 3 paralogues and is associated with 44 phenotypes. Ubiquitous expression in bone marrow (RPKM 117.9), lymph node (RPKM 72.6) and 25 other tissues.

功能概要

该基因是调节细胞生长和分化的抗增殖基因家族的成员。该基因的表达在细胞周期的 G0/G1 期最高，并在细胞进入 G1 期时下调。编码的蛋白质与几种核受体相互作用，并作为细胞分化的共激活因子发挥作用。该基因座已被证明与 B 细胞慢性淋巴细胞白血病病例中的 at (8;12) (q24;q22) 染色体易位有关。[RefSeq 提供，2008 年 10 月]

This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. [provided by RefSeq, Oct 2008]

BTG1 基因产物(1)

mRNA Protein Name
NM_001731.3 NP_001722.1 protein BTG1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables enzyme binding IPI
IPI: 通过物理相互作用推断
8663146 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9712883 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
11420681 GOA
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
1373383 GOA
involved in positive regulation of angiogenesis IMP
IMP: 通过突变表型推断
15033446 GOA
involved in positive regulation of endothelial cell differentiation IMP
IMP: 通过突变表型推断
15033446 GOA
involved in positive regulation of fibroblast apoptotic process IMP
IMP: 通过突变表型推断
9690562 GOA
acts upstream of or within positive regulation of myoblast differentiation IDA
IDA: 通过直接分析推断
11420681 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11420681 GOA
located in cytoplasm IMP
IMP: 通过突变表型推断
11420681 GOA
located in nucleus IDA
IDA: 通过直接分析推断
9820826 GOA
located in nucleus IMP
IMP: 通过突变表型推断
11420681 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BTG1 蛋白结构

BTG

BTG: BTG family (11 - 126)

  • 0
  • 100
  • 171 a.a.
蛋白主名 其他名称

protein BTG1

B-cell translocation gene 1 protein

BTG1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Cross BTG1 P62324 Cnot7 Mus musculus Q60809
Y2H
9712883
Cross BTG1 P62324 Cnot7 Mus musculus Q60809
Pull Down
9712883
Intra BTG1 P62324 CNOT7 Homo sapiens Q9UIV1
Y2H
21900206
Intra BTG1 P62324 CNOT7 Homo sapiens Q9UIV1
Pull Down
11136725
Intra BTG1 P62324 CNOT7 Homo sapiens Q9UIV1
SLC
27107012
Intra BTG1 P62324 GRB2 Homo sapiens P62993
Validated Y2H
32296183
Intra BTG1 P62324 FADD Homo sapiens Q13158
Validated Y2H
32296183
Intra BTG1 P62324 CNOT8 Homo sapiens Q9UFF9
Y2H Pooling
16189514
Intra BTG1 P62324 CNOT8 Homo sapiens Q9UFF9
Y2H
21900206
Intra BTG1 P62324 CNOT8 Homo sapiens Q9UFF9
Y2H
11136725
Intra BTG1 P62324 CNOT8 Homo sapiens Q9UFF9
Y2H Array
20211142
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos
Intellectual Developmental Disorder, Autosomal Dominant 33

MRD33

Autosomal Dominant Non-Syndromic Intellectual Disability 33

Mental Retardation, Autosomal Dominant 33

Autosomal Dominant Intellectual Developmental Disorder 33

Autosomal Dominant Mental Retardation 33

Mental Retardation, Autosomal Dominant, Type 33
Charcot-Marie-Tooth Disease

Cmt

Hmsn

Hereditary Motor And Sensory Neuropathy

Pma

Cmt - Charcot-Marie-Tooth Disease

Charcot Marie Tooth Disease

Charcot-Marie-Tooth Hereditary Neuropathy

Charcot-Marie-Tooth Syndrome

Peroneal Muscular Atrophy

Hereditary Motor And Sensory Neuropathies
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01662 BTG1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus BTG1 RGD RGD:2224
Canis familiaris BTG1 VGNC VGNC:38558
Bos taurus BTG1 VGNC VGNC:26597
Mus musculus BTG1 MGD MGI:88215
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