1. Gene
  2. FADD - Fas associated via death domain Gene

FADD - Fas associated via death domain Gene

中文名称:Fas 通过死亡域关联

种属: Homo sapiens

同用名: GIG3; IMD90; MORT1

基因 ID: 8772 | 基因类型: protein coding

关于 FADD

Cytogenetic location: 11q13.3 Genomic coordinates (GRCh38): 11:70,203,296-70,207,390 (from NCBI)

This gene has 1 transcript (splice variant), 180 orthologues and is associated with 3 phenotypes. Ubiquitous expression in kidney (RPKM 9.3), colon (RPKM 8.7) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种衔接分子,可与各种细胞表面受体相互作用并介导细胞凋亡信号。通过其 C 端死亡结构域,该蛋白可被 TNFRSF6/Fas 受体、肿瘤坏死因子受体、TNFRSF25 和 TNFSF10/TRAIL 受体募集,从而参与由这些受体启动的死亡信号传导。该蛋白与受体的相互作用揭示了该蛋白的 N 末端效应结构域,使其能够募集 Caspase-8,从而激活半胱氨酸蛋白酶级联反应。小鼠基因敲除研究也表明这种蛋白质在早期 T 细胞发育中的重要性。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit Caspase-8, and thereby activate the cysteine Protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]

FADD 基因产物(1)

mRNA Protein Name
NM_003824.4 NP_003815.1 FAS-associated death domain protein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables caspase binding IDA
IDA: 通过直接分析推断
24025841 GOA
enables caspase binding IPI
IPI: 通过物理相互作用推断
9343261 GOA
enables death effector domain binding IPI
IPI: 通过物理相互作用推断
11717445 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
7536190 GOA
enables protease binding IPI
IPI: 通过物理相互作用推断
9208847 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
7536190 GOA
enables protein-macromolecule adaptor activity IDA
IDA: 通过直接分析推断
8565075 GOA
enables tumor necrosis factor receptor superfamily binding IPI
IPI: 通过物理相互作用推断
21109225 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in TRAIL-activated apoptotic signaling pathway IDA
IDA: 通过直接分析推断
21785459 GOA
involved in activation of cysteine-type endopeptidase activity IDA
IDA: 通过直接分析推断
18387192 GOA
involved in apoptotic process IMP
IMP: 通过突变表型推断
22891283 GOA
involved in apoptotic signaling pathway IDA
IDA: 通过直接分析推断
8565075 GOA
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
19593445 GOA
involved in death-inducing signaling complex assembly IDA
IDA: 通过直接分析推断
24025841 GOA
involved in defense response to virus IMP
IMP: 通过突变表型推断
21109225 GOA
involved in extrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
21785459 GOA
involved in extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
16611992 GOA
involved in extrinsic apoptotic signaling pathway via death domain receptors IDA
IDA: 通过直接分析推断
9184224 GOA
involved in necroptotic signaling pathway IMP
IMP: 通过突变表型推断
11101870 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
11821383 GOA
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
20935634 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IEP
IEP: 通过表达模式推断
12761501 GOA
involved in positive regulation of extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
21525013 GOA
involved in positive regulation of interleukin-8 production IDA
IDA: 通过直接分析推断
16127453 GOA
involved in positive regulation of macrophage differentiation IMP
IMP: 通过突变表型推断
17047155 GOA
involved in positive regulation of proteolysis IDA
IDA: 通过直接分析推断
18387192 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16127453 GOA
involved in positive regulation of tumor necrosis factor production IDA
IDA: 通过直接分析推断
16127453 GOA
involved in positive regulation of type I interferon-mediated signaling pathway IMP
IMP: 通过突变表型推断
21109225 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of CD95 death-inducing signaling complex IDA
IDA: 通过直接分析推断
20935634 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
22510408 GOA
located in cytosol IDA
IDA: 通过直接分析推断
21785459 GOA
part of death-inducing signaling complex IDA
IDA: 通过直接分析推断
11101870 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
22510408 GOA
part of ripoptosome IDA
IDA: 通过直接分析推断
21737330 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

FADD 蛋白结构

DED

DED: Death effector domain (4 - 84)

Death

Death: Death domain (101 - 179)

  • 0
  • 100
  • 208 a.a.
蛋白主名 其他名称

FAS-associated death domain protein

Fas (TNFRSF6)-associated via death domain

关联疾病

疾病名称 别名
Immunodeficiency 90 With Encephalopathy, Functional Hyposplenia, And Hepatic Dysfunction

Infections, Recurrent, With Encephalopathy, Hepatic Dysfunction, And Cardiovascular Malformations

Fadd-Related Immunodeficiency

IMD90

Fadd Deficiency

Infections, Recurrent, Associated With Encephalopathy, Hepatic Dysfunction And Cardiovascular Malformations

IEHDCM

Otodental Dysplasia

Otodental Syndrome

Oculootodental Syndrome

Chromosome 11q13 Deletion Syndrome

Otodental Dysplasia Chromosome Deletion Syndrome

Globodontia

Ood

Molluscum Contagiosum

Water Warts

Molluscum Verrucosum

Autoimmune Lymphoproliferative Syndrome

ALPS

Canale-Smith Syndrome

Autoimmune Lymphoproliferative Syndrome, Type Ia

Autoimmune Lymphoproliferative Syndrome, Type Ib

Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant

Css

Autoimmune Lymphoproliferative Syndrome, Type 1b

Autoimmune Lymphoproliferative Syndrome, Type 1a

Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant

Fas Deficiency

Autoimmune Lymphoproliferative Syndrome 1a

ALPS1A

Autoimmune Lymphoproliferative Syndrome Type Ia

Autoimmune Lymphoproliferative Syndrome 1b

ALPS1B

Autoimmune Lymphoproliferative Syndrome Type Ib

Lymphoproliferative Syndrome

Lymphoproliferative Disorder

Lymphoproliferative Disorders

Lymphoproliferative Disorders, Susceptibility To

Caspase 8 Deficiency

Autoimmune Lymphoproliferative Syndrome Type 2b

Caspase-8 Deficiency

Ceds

Alps2b

Autoimmune Lymphoproliferative Syndrome, Type Iib

Alps With Recurrent Viral Infections

Autoimmune Lymphoproliferative Syndrome With Recurrent Viral Infections

Caspase 8 Deficiency Syndrome

Caspase 8 Lymphadenopathy Syndrome

Autoimmune Lymphoproliferative Syndrome Type Iib

Caspase Eight Deficiency State

CASP8D

Squamous Cell Carcinoma

Epidermoid Carcinoma

Squamous Cell Cancer

Carcinoma, Squamous Cell

Squamous Cell Skin Cancer

Malignant Squamous Cell Tumor

Squamous Carcinoma

Squamous Cell Epithelioma

Carcinoma Squamous Cell

Neoplasms, Squamous Cell

Squamous Cell Carcinoma - Category

Malignant Squamous Cell Neoplasm

Squamous Cell Carcinoma Of Skin

Type 1 Diabetes Mellitus 4

Diabetes Mellitus, Insulin-Dependent, 4

Iddm4

Insulin-Dependent Diabetes Mellitus 4

T1D4

Insulin-Dependent Diabetes Mellitus-4

Ectodermal Dysplasia

Congenital Ectodermal Defect

Congenital Ectodermal Dysplasia

Ectodermal Dysplasia Syndrome

Dysplasia, Ectodermal

Cervical Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of The Cervix Uteri

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Hypersensitivity Reaction Type Iv Disease

Immunoproliferative Disorders

Immunoproliferative Disease

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus FADD MGD MGI:109324
Rattus norvegicus FADD RGD RGD:628700
Felis catus FADD VGNC VGNC:102880
Bos taurus FADD VGNC VGNC:28700
Macaca mulatta FADD VGNC VGNC:110502
Canis familiaris FADD VGNC VGNC:51869
Others FADD NCBI