TRADD - TNFRSF1A associated via death domain Gene

中文名称：通过死亡域关联的 TNFRSF1A

种属: Homo sapiens

同用名: Hs.89862

基因 ID: 8717 | 基因类型: protein coding

关于 TRADD

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,154,185-67,159,909 (from NCBI)

This gene has 5 transcripts (splice variants) and 192 orthologues. Ubiquitous expression in stomach (RPKM 7.8), spleen (RPKM 7.4) and 25 other tissues.

功能概要

由该基因编码的蛋白质是一个包含与 TNFRSF1A/TNFR1 相互作用并介导程序性细胞死亡信号和 NF-kappaB 激活的衔接分子的死亡域。该蛋白结合衔接蛋白 TRAF2，减少 TRAF2 对凋亡抑制蛋白 (IAP) 的募集，从而抑制 TRAF2 介导的细胞凋亡。该蛋白还可以与受体 TNFRSF6/FAS 和衔接蛋白 FADD/MORT1 相互作用，并参与 Fas 诱导的细胞死亡通路。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated Apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]

TRADD 基因产物(2)

mRNA	Protein	Name
NM_001323552.2	NP_001310481.1	tumor necrosis factor receptor type 1-associated DEATH domain protein
NM_003789.4	NP_003780.1	tumor necrosis factor receptor type 1-associated DEATH domain protein

TRADD 蛋白结构

TRADD_N

Death

0
100
200
312 a.a.

蛋白主名

其他名称

tumor necrosis factor receptor type 1-associated DEATH domain protein

TNFR1-associated death domain protein

TRADD 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TRADD	Q15628	KRT18	Homo sapiens	P05783	IF	11684708
种属内	TRADD	Q15628	KRT18	Homo sapiens	P05783	Y2H	11684708
种属内	TRADD	Q15628	TNFRSF1A	Homo sapiens	P19438	Y2H	8565075
种属内	TRADD	Q15628	TNFRSF1A	Homo sapiens	P19438	Y2H	7758105
种属内	TRADD	Q15628	TNFRSF1A	Homo sapiens	P19438	Anti Tag CoIP	23955153
种属内	TRADD	Q15628	TNFRSF1A	Homo sapiens	P19438	Anti Bait CoIP	7758105
种属内	TRADD	Q15628	TRAF2	Homo sapiens	Q12933	ViroTrap	30561431
种属内	TRADD	Q15628	TRAF2	Homo sapiens	Q12933	Anti Tag CoIP	23955153
种属内	TRADD	Q15628	FADD	Homo sapiens	Q13158	ViroTrap	30561431
种属内	TRADD	Q15628	FADD	Homo sapiens	Q13158	Anti Tag CoIP	23955153
种属间	TRADD	Q15628	nleB1	Escherichia coli O127:H6	B7UI21	Anti Tag CoIP	23955153
种属间	TRADD	Q15628	LMP1	Epstein-Barr virus	P03230	Anti Tag CoIP	18198944
种属间	TRADD	Q15628	LMP1	Epstein-Barr virus	P03230	Anti Bait CoIP	19379743

种属间: 跨种属相互作用 种属内: 同种属相互作用

TRADD 抗体

目录号	产品名	应用	反应物种
HY-P82531	TRADD Antibody (YA2276)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Epidermolysis Bullosa Simplex

Ebs	Epidermolysis Bullosa Intraepidermic
Epidermolytic Epidermolysis Bullosa

Ectodermal Dysplasia

Congenital Ectodermal Defect	Congenital Ectodermal Dysplasia
Ectodermal Dysplasia Syndrome	Dysplasia, Ectodermal

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Autoimmune Lymphoproliferative Syndrome

ALPS	Canale-Smith Syndrome
Autoimmune Lymphoproliferative Syndrome, Type Ia	Autoimmune Lymphoproliferative Syndrome, Type Ib
Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant	Css
Autoimmune Lymphoproliferative Syndrome, Type 1b	Autoimmune Lymphoproliferative Syndrome, Type 1a
Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant	Fas Deficiency
Autoimmune Lymphoproliferative Syndrome 1a	ALPS1A
Autoimmune Lymphoproliferative Syndrome Type Ia	Autoimmune Lymphoproliferative Syndrome 1b
ALPS1B	Autoimmune Lymphoproliferative Syndrome Type Ib

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-134050	Apostatin-1		99.84%	否
HY-138779	ICCB-19 hydrochloride		99.24%	否
HY-114573	TNF-α-IN-19	Inhibitor	/	否
HY-RS14966	TRADD Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	TRADD	MGD	MGI:109200
Macaca mulatta	TRADD	VGNC	VGNC:78640
Bos taurus	TRADD	VGNC	VGNC:36269
Rattus norvegicus	TRADD	RGD	RGD:621313
Canis familiaris	TRADD	VGNC	VGNC:47761
Others	TRADD	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TRADD - TNFRSF1A associated via death domain Gene

关于 TRADD

功能概要

TRADD 基因产物(2)

TRADD 蛋白结构

TRADD 蛋白互作信息

TRADD 抗体

关联疾病

直系同源

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TRADD - TNFRSF1A associated via death domain Gene

关于 TRADD

功能概要

TRADD 基因产物(2)

TRADD 蛋白结构

TRADD 蛋白互作信息

TRADD 抗体

关联疾病

相关产品

直系同源

热门区域

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C

F

G

H

J

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