TNRC6A - trinucleotide repeat containing adaptor 6A Gene

中文名称：含三核苷酸重复序列的适配子 6A

种属: Homo sapiens

同用名: GW1; FAME6; GW182; TNRC6; CAGH26

基因 ID: 27327 | 基因类型: protein coding

关于 TNRC6A

Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38): 16:24,610,205-24,826,218 (from NCBI)

This gene has 18 transcripts (splice variants), 1 gene allele, 205 orthologues, 5 paralogues and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 11.5), endometrium (RPKM 10.0) and 25 other tissues.

功能概要

该基因编码含有 6 个蛋白质家族的三核苷酸重复序列的成员。该蛋白质通过 RNA 干扰 (RNAi) 和 MicroRNA 途径在转录后基因沉默中发挥作用。该蛋白质与称为 GW 体或 P 体的细胞质体中的信使 RNA 和 Argonaute 蛋白结合。抑制该基因的表达会使其他 GW 体蛋白离域并损害 RNAi 和 MicroRNA 诱导的基因沉默。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and MicroRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]

TNRC6A 基因产物(3)

mRNA	Protein	Name
NM_001330520.3	NP_001317449.1	trinucleotide repeat-containing gene 6A protein isoform 2
NM_001351850.2	NP_001338779.1	trinucleotide repeat-containing gene 6A protein isoform 3
NM_014494.4	NP_055309.2	trinucleotide repeat-containing gene 6A protein isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	19167051	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in P-body assembly	IDA IDA: 通过直接分析推断	31400113	GOA
involved in miRNA-mediated gene silencing by inhibition of translation	IDA IDA: 通过直接分析推断	17671087	GOA
involved in miRNA-mediated post-transcriptional gene silencing	IMP IMP: 通过突变表型推断	23172285	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in P-body	IDA IDA: 通过直接分析推断	31400113	GOA
located in P-body	IDA IDA: 通过直接分析推断	20616046	GOA
part of RISC complex	IDA IDA: 通过直接分析推断	17671087	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TNRC6A 蛋白结构

Ago_hook

RRM_5

0
400
800
1200
1600
1962 a.a.

蛋白主名

其他名称

trinucleotide repeat-containing gene 6A protein

CAG repeat protein 26

TNRC6A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	TNRC6A	Q8NDV7	CNOT1	Homo sapiens	A5YKK6	Anti Bait CoIP	21981923
Intra	TNRC6A	Q8NDV7	AGO3	Homo sapiens	Q9H9G7	Confocal	19383768
Intra	TNRC6A	Q8NDV7	AGO3	Homo sapiens	Q9H9G7	Pull Down	19324964
Intra	TNRC6A	Q8NDV7	AGO3	Homo sapiens	Q9H9G7	Anti Tag CoIP	19383768
Intra	TNRC6A	Q8NDV7	AGO4	Homo sapiens	Q9HCK5	Confocal	19383768
Intra	TNRC6A	Q8NDV7	AGO4	Homo sapiens	Q9HCK5	Anti Tag CoIP	19383768
Intra	TNRC6A	Q8NDV7	PAN3	Homo sapiens	Q58A45	Anti Bait CoIP	21981923
Intra	TNRC6A	Q8NDV7	TRIP13	Homo sapiens	Q15645	Y2H Prey Pooling	25416956
Intra	TNRC6A	Q8NDV7	AGO1	Homo sapiens	Q9UL18	Anti Tag CoIP	33961781
Intra	TNRC6A	Q8NDV7	AGO1	Homo sapiens	Q9UL18	Pull Down	19324964
Intra	TNRC6A	Q8NDV7	AGO1	Homo sapiens	Q9UL18	Confocal	19383768
Intra	TNRC6A	Q8NDV7	AGO1	Homo sapiens	Q9UL18	Anti Tag CoIP	19383768
Intra	TNRC6A	Q8NDV7	AGO1	Homo sapiens	Q9UL18	Anti Bait CoIP	22484317
Intra	TNRC6A	Q8NDV7	AGO2	Homo sapiens	Q9UKV8	Anti Bait CoIP	28877994
Intra	TNRC6A	Q8NDV7	AGO2	Homo sapiens	Q9UKV8	PLA	28683311
Intra	TNRC6A	Q8NDV7	AGO2	Homo sapiens	Q9UKV8	Confocal	19383768
Intra	TNRC6A	Q8NDV7	AGO2	Homo sapiens	Q9UKV8	Confocal	28877994
Intra	TNRC6A	Q8NDV7	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	19383768
Intra	TNRC6A	Q8NDV7	AGO2	Homo sapiens	Q9UKV8	Anti Bait CoIP	22484317
Intra	TNRC6A	Q8NDV7	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	21840310
Intra	TNRC6A	Q8NDV7	PABPC1	Homo sapiens	P11940	Anti Bait CoIP	28877994

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Epilepsy, Familial Adult Myoclonic, 6

FAME6	Benign Adult Familial Myoclonic Epilepsy 6
Bafme6	Fcmte6
Cortical Myoclonic Tremor With Epilepsy, Familial, 6	Familial Adult Myoclonic Epilepsy 6
Familial Cortical Myoclonic Tremor And Epilepsy 6	Epilepsy, Myoclonic, Familial Adult, Type 6

Epilepsy, Familial Adult Myoclonic, 1

FAME1	Benign Adult Familial Myoclonic Epilepsy 1
Bafme1	Fcmte1
Cortical Myoclonic Tremor With Epilepsy, Familial, 1	Familial Adult Myoclonic Epilepsy 1
Familial Cortical Myoclonic Tremor And Epilepsy 1	Epilepsy, Myoclonic, Familial Adult, Type 1

Epilepsy, Familial Adult Myoclonic, 7

FAME7	Bafme7
Fcmte7	Benign Adult Familial Myoclonic Epilepsy 7
Cortical Myoclonic Tremor With Epilepsy, Familial, 7	Familial Adult Myoclonic Epilepsy 7
Familial Cortical Myoclonic Tremor And Epilepsy 7	Benign Adult Familial Myoclonic Epilepsy 27
Epilepsy, Myoclonic, Familial Adult, Type 7

Epilepsy, Familial Adult Myoclonic, 2

FAME2	Benign Adult Familial Myoclonic Epilepsy 2
Bafme2	Fcmte2
Adcme	Cortical Myoclonic Tremor With Epilepsy, Familial, 2
Cortical Myoclonus And Epilepsy, Autosomal Dominant	Familial Adult Myoclonic Epilepsy 2
Epilepsy, Myoclonic, Benign Adult Familial, Type 2	Autosomal Dominant Cortical Myoclonus And Epilepsy
Familial Cortical Myoclonic Tremor And Epilepsy 2	Epilepsy, Myoclonic, Familial Adult, Type 2

Epilepsy, Familial Adult Myoclonic, 3

FAME3	Fcmte3
Cortical Myoclonic Tremor With Epilepsy, Familial, 3	Familial Adult Myoclonic Epilepsy 3
Familial Cortical Myoclonic Tremor And Epilepsy 3	Epilepsy, Myoclonic, Familial Adult, Type 3

Epilepsy, Familial Adult Myoclonic, 4

FAME4	Fcmte4
Cortical Myoclonic Tremor With Epilepsy, Familial, 4	Familial Adult Myoclonic Epilepsy 4
Epilepsy, Myoclonic, Familial Adult, 4	Familial Cortical Myoclonic Tremor And Epilepsy 4
Epilepsy, Myoclonic, Familial Adult, Type 4

Familial Adult Myoclonic Epilepsy

Benign Adult Familial Myoclonus Epilepsy	Bafme
Benign Adult Familial Myoclonic Epilepsy	Fame
Familial Cortical Myoclonic Tremor And Epilepsy	Fcmte
Adcme	Autosomal Dominant Cortical Myoclonus And Epilepsy
Fam	Epilepsy, Myoclonic, Familial Adult
Epilepsy, Myoclonic, Benign Adult Familial, Type 2

Cervical Non-Keratinizing Squamous Cell Carcinoma

Granulomatous Disease, Chronic, Autosomal Recessive, 3

CGD3	Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Iii
Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 3	Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Iii
Cgd, Autosomal Recessive Cytochrome B-Positive, Type Iii	Granulomatous Disease, Chronic, Due To Ncf4 Deficiency
Chronic Granulomatous Disease 3, Autosomal Recessive	Autosomal Recessive Chronic Granulomatous Disease 3
Autosomal Recessive Cytochrome B-Positive Cgd Type Iii	Cdg3
Chronic Granulomatous Disease Due To Ncf4 Deficiency	Cgd Autosomal Recessive Cytochrome B-Positive Type Iii
Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Iii	Granulomatous Disease Chronic Due To Ncf4 Deficiency
Granulomatous Disease, Chronic, Autosomal Recessive Cytochrome B-Positive, Type 3

Mild Cognitive Impairment

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Adolescence-Adult Electroclinical Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14864	TNRC6A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	TNRC6A	VGNC	VGNC:36204
Felis catus	TNRC6A	VGNC	VGNC:80697
Canis familiaris	TNRC6A	VGNC	VGNC:47699
Macaca mulatta	TNRC6A	VGNC	VGNC:78611
Mus musculus	TNRC6A	MGD	MGI:2385292
Rattus norvegicus	TNRC6A	RGD	RGD:1307268

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TNRC6A - trinucleotide repeat containing adaptor 6A Gene

关于 TNRC6A

功能概要

TNRC6A 基因产物(3)

TNRC6A 蛋白结构

TNRC6A 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

TNRC6A - trinucleotide repeat containing adaptor 6A Gene

关于 TNRC6A

功能概要

TNRC6A 基因产物(3)

TNRC6A 蛋白结构

TNRC6A 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z