AGO4 - argonaute RISC component 4 Gene

中文名称：argonaute RISC 组件 4

种属: Homo sapiens

同用名: EIF2C4

基因 ID: 192670 | 基因类型: protein coding

关于 AGO4

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:35,807,636-35,857,890 (from NCBI)

This gene has 3 transcripts (splice variants), 215 orthologues and 3 paralogues. Ubiquitous expression in skin (RPKM 10.1), bone marrow (RPKM 8.1) and 25 other tissues.

功能概要

该基因编码包含 PAZ 和 PIWI 结构域的 Argonaute 蛋白质家族成员，在 RNA 干扰和短干扰 RNA 介导的基因沉默中发挥不可或缺的作用。该基因位于相关家族成员簇中的 1 号染色体上。[RefSeq 提供，2017 年 3 月]

This gene encodes a member of the Argonaute family of proteins which contain PAZ and PIWI domains and play an integral role in RNA interference and short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of related family members. [provided by RefSeq, Mar 2017]

AGO4 基因产物(1)

mRNA	Protein	Name
NM_017629.4	NP_060099.2	protein argonaute-4

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables double-stranded RNA binding	IDA IDA: 通过直接分析推断	19966796	GOA
enables miRNA binding	IDA IDA: 通过直接分析推断	15260970	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15766526	GOA
enables single-stranded RNA binding	IDA IDA: 通过直接分析推断	19966796	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in RISC complex assembly	IDA IDA: 通过直接分析推断	19966796	GOA
involved in RNA secondary structure unwinding	IDA IDA: 通过直接分析推断	19966796	GOA
involved in RNA secondary structure unwinding	IMP IMP: 通过突变表型推断	22795694	GOA
involved in mRNA catabolic process	IDA IDA: 通过直接分析推断	18771919	GOA
involved in miRNA processing	IMP IMP: 通过突变表型推断	22795694	GOA
involved in miRNA-mediated gene silencing by inhibition of translation	IDA IDA: 通过直接分析推断	18771919	GOA
NOT involved in miRNA-mediated gene silencing by mRNA destabilization	IDA IDA: 通过直接分析推断	15260970	GOA
involved in pre-miRNA processing	IDA IDA: 通过直接分析推断	19966796	GOA
NOT involved in siRNA-mediated gene silencing by mRNA destabilization	IDA IDA: 通过直接分析推断	15260970	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of RISC complex	IDA IDA: 通过直接分析推断	15260970	GOA
part of RISC-loading complex	IDA IDA: 通过直接分析推断	19966796	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	15260970	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AGO4 蛋白结构

ArgoL1

PAZ

Piwi

0
200
400
600
800
861 a.a.

蛋白主名

其他名称

protein argonaute-4

argonaute 4, RISC catalytic component

AGO4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	AGO4	Q9HCK5	TNRC6A	Homo sapiens	Q8NDV7	Anti Tag CoIP	19167051
种属内	AGO4	Q9HCK5	TNRC6A	Homo sapiens	Q8NDV7	Pull Down	19324964
种属内	AGO4	Q9HCK5	TNRC6A	Homo sapiens	Q8NDV7	Anti Tag CoIP	33961781
种属内	AGO4	Q9HCK5	IPO8	Homo sapiens	O15397	Anti Tag CoIP	19167051
种属内	AGO4	Q9HCK5	TNRC6C	Homo sapiens	Q9HCJ0	Anti Tag CoIP	33961781
种属内	AGO4	Q9HCK5	TNRC6C	Homo sapiens	Q9HCJ0	Anti Tag CoIP	19383768

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cartilage-Hair Hypoplasia

Metaphyseal Chondrodysplasia, Mckusick Type	CHH
Mckusick Type Metaphyseal Chondrodysplasia	Metaphyseal Dysplasia Without Hypotrichosis
Cartilage Hair Hypoplasia Like Syndrome	Metaphyseal Chondrodysplasia Mckusick Type
Chhv	Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only
Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency	Cartilage-Hair Syndrome
Mckusick'S Metaphyseal Chondrodysplasia Syndrome	Metaphyseal Chondrodysplasia, Recessive Type
Autosomal Recessive Metaphyseal Chondrodysplasia

Epiphyseal Dysplasia, Multiple, 2

EDM2	Multiple Epiphyseal Dysplasia 2
Dysplasia, Epiphyseal, Multiple, Type 2

Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly

Ectodermal Dysplasia

Congenital Ectodermal Defect	Congenital Ectodermal Dysplasia
Ectodermal Dysplasia Syndrome	Dysplasia, Ectodermal

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00455	AGO4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	AGO4	VGNC	VGNC:25733
Felis catus	AGO4	VGNC	VGNC:80129
Rattus norvegicus	AGO4	RGD	RGD:1304583
Mus musculus	AGO4	MGD	MGI:1924100
Canis familiaris	AGO4	VGNC	VGNC:37709
Macaca mulatta	AGO4	VGNC	VGNC:81348

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4