IPO8 - importin 8 Gene

中文名称：导入 8

种属: Homo sapiens

同用名: VISS; RANBP8

关于 IPO8

功能概要

importin-alpha/beta 复合物和 GTPase Ran 介导具有经典核定位信号的蛋白质的核输入。由该基因编码的蛋白质是大约 20 个潜在 Ran 目标的成员，这些目标共享与 importin-beta 的 Ran 结合位点相关的序列基序。这种蛋白质与核孔复合体结合，并与 RanGTP 和 RANBP1 一起抑制 Ran GTP 酶的 GAP 刺激。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2010 年 7 月]

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]