2. Gene
  3. ZNF331 - zinc finger protein 331 Gene

ZNF331 - zinc finger protein 331 Gene

  • 基因
  • 蛋白
  • 相关产品

中文名称：锌指蛋白 331

种属: Homo sapiens

同用名: RITA; ZNF361; ZNF463

基因 ID: 55422 | 基因类型: protein coding

关于 ZNF331

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:53,503,235-53,580,269 (from NCBI)

This gene has 28 transcripts (splice variants), 67 orthologues, 174 paralogues and is associated with 75 phenotypes. Broad expression in adrenal (RPKM 22.0), placenta (RPKM 9.5) and 20 other tissues.

功能概要

该基因编码一种锌指蛋白，该蛋白含有在转录抑制因子中发现的 KRAB (Kruppel 相关框) 结构域。该基因可能在癌细胞中被甲基化和沉默。该基因位于差异甲基化区域 (DMR) 内，并在胎盘中显示等位基因特异性表达。可变剪接和替代启动子的使用导致编码相同蛋白质的多个转录变体。[RefSeq 提供，2015 年 11 月]

This gene encodes a zinc finger protein containing a KRAB (Kruppel-associated box) domain found in transcriptional repressors. This gene may be methylated and silenced in Cancer cells. This gene is located within a differentially methylated region (DMR) and shows allele-specific expression in placenta. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding the same protein. [provided by RefSeq, Nov 2015]

ZNF331 基因产物(16)

mRNA Protein Name
NM_001079906.2 NP_001073375.1 zinc finger protein 331
NM_001079907.1 NP_001073376.1 zinc finger protein 331
NM_001253798.2 NP_001240727.1 zinc finger protein 331
NM_001253799.2 NP_001240728.1 zinc finger protein 331
NM_001253800.3 NP_001240729.1 zinc finger protein 331
NM_001253801.2 NP_001240730.1 zinc finger protein 331
NM_001317113.2 NP_001304042.1 zinc finger protein 331
NM_001317114.2 NP_001304043.1 zinc finger protein 331
NM_001317115.2 NP_001304044.1 zinc finger protein 331
NM_001317116.2 NP_001304045.1 zinc finger protein 331
NM_001317117.1 NP_001304046.1 zinc finger protein 331
NM_001317118.1 NP_001304047.1 zinc finger protein 331
NM_001317119.1 NP_001304048.1 zinc finger protein 331
NM_001317120.2 NP_001304049.1 zinc finger protein 331
NM_001317121.1 NP_001304050.1 zinc finger protein 331
NM_018555.6 NP_061025.5 zinc finger protein 331
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
26496610 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZNF331 蛋白结构

KRAB

KRAB: KRAB box (6 - 46)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (146 - 168)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (174 - 196)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (201 - 225)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (230 - 254)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (260 - 280)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (286 - 310)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (314 - 336)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (341 - 365)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (369 - 392)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (397 - 422)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (426 - 450)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 463 a.a.
蛋白主名 其他名称

zinc finger protein 331

C2H2-like zinc finger protein rearranged in thyroid adenomas

ZNF331 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ZNF331 Q9NQX6 IPO8 Homo sapiens O15397
Anti Tag CoIP
33961781
Intra ZNF331 Q9NQX6 IPO8 Homo sapiens O15397
Anti Tag CoIP
28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16126 ZNF331 Human Pre-designed siRNA Set A Pre-designed Sets / 否
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