TNRC6C - trinucleotide repeat containing adaptor 6C Gene

中文名称：含三核苷酸重复序列的适配子 6C

种属: Homo sapiens

基因 ID: 57690 | 基因类型: protein coding

关于 TNRC6C

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:77,957,557-78,108,835 (from NCBI)

This gene has 11 transcripts (splice variants), 198 orthologues and 5 paralogues. Ubiquitous expression in brain (RPKM 4.2), testis (RPKM 3.1) and 25 other tissues.

功能概要

预测启用 RNA 结合活性。通过 miRNA 参与基因沉默；核转录 mRNA 分解代谢过程的正调控，脱腺苷酸依赖性衰变；和核转录 mRNA poly (A) 尾部缩短的正调控。预测位于胞质溶胶中。预计在 P 体和核质中具有活性。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable RNA binding activity. Involved in gene silencing by miRNA; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Predicted to be located in cytosol. Predicted to be active in P-body and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TNRC6C 基因产物(7)

mRNA	Protein	Name
NM_001142640.2	NP_001136112.2	trinucleotide repeat-containing gene 6C protein isoform 1
NM_001395508.1	NP_001382437.1	trinucleotide repeat-containing gene 6C protein isoform 3
NM_001395509.1	NP_001382438.1	trinucleotide repeat-containing gene 6C protein isoform 4
NM_001395510.1	NP_001382439.1	trinucleotide repeat-containing gene 6C protein isoform 5
NM_001395511.1	NP_001382440.1	trinucleotide repeat-containing gene 6C protein isoform 6
NM_001395512.1	NP_001382441.1	trinucleotide repeat-containing gene 6C protein isoform 7
NM_018996.3	NP_061869.2	trinucleotide repeat-containing gene 6C protein isoform 2

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	19383768	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in miRNA-mediated post-transcriptional gene silencing	IGI IGI: 通过遗传相互作用推断	23172285	GOA
involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA IDA: 通过直接分析推断	21984185	GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IDA IDA: 通过直接分析推断	21984185	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TNRC6C 蛋白结构

Ago_hook

UBA

M_domain

RRM_5

0
300
600
900
1200
1500
1690 a.a.

蛋白主名

其他名称

trinucleotide repeat-containing gene 6C protein

trinucleotide repeat containing 6C

TNRC6C 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TNRC6C	Q9HCJ0	CNOT6L	Homo sapiens	Q96LI5	Pull Down	21984185
种属内	TNRC6C	Q9HCJ0	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	21981923
种属内	TNRC6C	Q9HCJ0	CNOT10	Homo sapiens	Q9H9A5	Pull Down	21984185
种属内	TNRC6C	Q9HCJ0	CNOT10	Homo sapiens	Q9H9A5	Anti Tag CoIP	21981923
种属内	TNRC6C	Q9HCJ0	CNOT1	Homo sapiens	A5YKK6	Pull Down	21984185
种属内	TNRC6C	Q9HCJ0	CNOT1	Homo sapiens	A5YKK6	Anti Tag CoIP	21981923
种属内	TNRC6C	Q9HCJ0	CNOT6	Homo sapiens	Q9ULM6	Anti Tag CoIP	21981923
种属内	TNRC6C	Q9HCJ0	CNOT7	Homo sapiens	Q9UIV1	Anti Tag CoIP	21981923
种属内	TNRC6C	Q9HCJ0	CNOT7	Homo sapiens	Q9UIV1	Pull Down	21984185
种属内	TNRC6C	Q9HCJ0	AGO4	Homo sapiens	Q9HCK5	Confocal	19383768
种属内	TNRC6C	Q9HCJ0	PAN3	Homo sapiens	Q58A45	Anti Tag CoIP	21981923
种属间	TNRC6C	Q9HCJ0	Ago2	Mus musculus	Q8CJG0	Anti Tag CoIP	23340509
种属内	TNRC6C	Q9HCJ0	CNOT2	Homo sapiens	Q9NZN8	Pull Down	21984185
种属内	TNRC6C	Q9HCJ0	CNOT2	Homo sapiens	Q9NZN8	Anti Tag CoIP	21981923
种属内	TNRC6C	Q9HCJ0	CNOT3	Homo sapiens	O75175	Pull Down	21984185
种属内	TNRC6C	Q9HCJ0	CNOT3	Homo sapiens	O75175	Anti Tag CoIP	21981923
种属内	TNRC6C	Q9HCJ0	PABPC1	Homo sapiens	P11940	X-Ray Diffraction	20098421
种属内	TNRC6C	Q9HCJ0	PABPC1	Homo sapiens	P11940	ITC	20181956
种属内	TNRC6C	Q9HCJ0	PABPC1	Homo sapiens	P11940	Anti Tag CoIP	23340509
种属内	TNRC6C	Q9HCJ0	PABPC1	Homo sapiens	P11940	GMS	20098421
种属内	TNRC6C	Q9HCJ0	PABPC1	Homo sapiens	P11940	Anti Tag CoIP	21981923
种属内	TNRC6C	Q9HCJ0	PABPC1	Homo sapiens	P11940	NMR	20181956
种属内	TNRC6C	Q9HCJ0	PABPC1	Homo sapiens	P11940	Pull Down	19716330
种属内	TNRC6C	Q9HCJ0	PABPC1	Homo sapiens	P11940	Pull Down	20098421
种属内	TNRC6C	Q9HCJ0	PABPC1	Homo sapiens	P11940	Anti Tag CoIP	19716330

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14866	TNRC6C Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	TNRC6C	VGNC	VGNC:47700
Rattus norvegicus	TNRC6C	RGD	RGD:1310027
Macaca mulatta	TNRC6C	VGNC	VGNC:79800
Mus musculus	TNRC6C	MGD	MGI:2443265
Bos taurus	TNRC6C	VGNC	VGNC:36206
Felis catus	TNRC6C	VGNC	VGNC:99564

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