1. Gene
  2. PAN3 - poly(A) specific ribonuclease subunit PAN3 Gene

PAN3 - poly(A) specific ribonuclease subunit PAN3 Gene

中文名称:poly (A) 特异性核糖核酸酶亚基 PAN3

种属: Homo sapiens

基因 ID: 255967 | 基因类型: protein coding

关于 PAN3

Cytogenetic location: 13q12.2 Genomic coordinates (GRCh38): 13:28,138,193-28,295,335 (from NCBI)

This gene has 4 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in bone marrow (RPKM 8.7), spleen (RPKM 8.4) and 25 other tissues.

功能概要

有助于聚 (A) 特异性核糖核酸酶活性。预计参与核转录的 mRNA poly (A) 尾部缩短。预测作用于核转录 mRNA 脱腺苷酸化依赖性脱帽的上游或内部;细胞质 mRNA 加工体组装的正调控;和蛋白质靶向。 PAN 复合体的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Contributes to poly(A)-specific ribonuclease activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within deadenylation-dependent decapping of nuclear-transcribed mRNA; positive regulation of cytoplasmic mRNA processing body assembly; and protein targeting. Part of PAN complex. [provided by Alliance of Genome Resources, Apr 2022]

PAN3 基因产物(1)

mRNA Protein Name
NM_175854.8 NP_787050.6 PAN2-PAN3 deadenylation complex subunit PAN3
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to poly(A)-specific ribonuclease activity IDA
IDA: 通过直接分析推断
14583602 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14583602 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of PAN complex IDA
IDA: 通过直接分析推断
14583602 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

PAN2-PAN3 deadenylation complex subunit PAN3

PAB-dependent poly(A)-specific ribonuclease subunit 3

关联疾病

疾病名称 别名
Balanoposthitis

Balanitis Due To Infection

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus PAN3 VGNC VGNC:102279
Mus musculus PAN3 MGD MGI:1919837
Macaca mulatta PAN3 VGNC VGNC:106281
Bos taurus PAN3 VGNC VGNC:53830
Canis familiaris PAN3 VGNC VGNC:59088
Rattus norvegicus PAN3 RGD RGD:1590880
Macaca fascicularis PAN3 NCBI NCBI:102142167
Susscrofa domestica PAN3 NCBI
Others PAN3 NCBI