2. Gene
  3. PAN2 - poly(A) specific ribonuclease subunit PAN2 Gene

PAN2 - poly(A) specific ribonuclease subunit PAN2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：poly (A) 特异性核糖核酸酶亚基 PAN2

种属: Homo sapiens

同用名: USP52

基因 ID: 9924 | 基因类型: protein coding

关于 PAN2

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,316,936-56,334,000 (from NCBI)

This gene has 21 transcripts (splice variants) and 223 orthologues. Ubiquitous expression in testis (RPKM 19.6), thyroid (RPKM 18.6) and 25 other tissues.

功能概要

该基因编码一种脱腺苷酶，作为多聚腺苷酸结合蛋白依赖性聚 (A) 核酸酶复合物的催化亚基发挥作用。编码的蛋白质是镁依赖性 3' 到 5' 核糖核酸外切酶，参与细胞质 mRNA 的降解。交替剪接导致多个转录本变体。[RefSeq 提供，2009 年 10 月]

This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

PAN2 基因产物(13)

mRNA Protein Name
NM_001127460.4 NP_001120932.2 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 1
NM_001166279.3 NP_001159751.2 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 2
NM_001394699.1 NP_001381628.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 1
NM_001394700.1 NP_001381629.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 3
NM_001394701.1 NP_001381630.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 4
NM_001394702.1 NP_001381631.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 4
NM_001394703.1 NP_001381632.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 5
NM_001394704.1 NP_001381633.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 6
NM_001394705.1 NP_001381634.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 7
NM_001394706.1 NP_001381635.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 8
NM_001394707.1 NP_001381636.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 8
NM_001394708.1 NP_001381637.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 9
NM_014871.6 NP_055686.4 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 3
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3'-5'-RNA exonuclease activity IDA
IDA: 通过直接分析推断
14583602 GOA
enables poly(A)-specific ribonuclease activity IDA
IDA: 通过直接分析推断
14583602 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14583602 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of PAN complex IDA
IDA: 通过直接分析推断
14583602 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PAN2 蛋白结构

UCH_1

UCH_1: Ubiquitin carboxyl-terminal hydrolase (517 - 898)

RNase_T

RNase_T: Exonuclease (975 - 1147)

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  • 1202 a.a.
蛋白主名 其他名称

PAN2-PAN3 deadenylation complex catalytic subunit PAN2

PAB-dependent poly(A)-specific ribonuclease subunit 2

PAN2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PAN2 Q504Q3 PAN3 Homo sapiens Q58A45
Anti Tag CoIP
14583602
种属内
PAN2 Q504Q3 PAN3 Homo sapiens Q58A45
Anti Tag CoIP
19615732
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10014 PAN2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PAN2 MGD MGI:1918984
Bos taurus PAN2 VGNC VGNC:58444
Macaca mulatta PAN2 VGNC VGNC:100085
Rattus norvegicus PAN2 RGD RGD:1303301
Canis familiaris PAN2 VGNC VGNC:54530
Others PAN2 NCBI
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