CNOT9 - CCR4-NOT transcription complex subunit 9 Gene

中文名称：CCR4-NOT 转录复合物亚基 9

种属: Homo sapiens

同用名: RCD1; CAF40; CT129; RCD-1; RQCD1

基因 ID: 9125 | 基因类型: protein coding

关于 CNOT9

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,568,839-218,597,080 (from NCBI)

This gene has 9 transcripts (splice variants) and 241 orthologues. Ubiquitous expression in testis (RPKM 10.4), lymph node (RPKM 9.1) and 25 other tissues.

功能概要

该基因编码高度保守的 RCD1 蛋白家族的成员。编码的蛋白质是转录辅因子和 CCR4-NOT 复合物的核心蛋白。它可能参与信号转导以及视黄酸调节的细胞分化和发育。已经描述了该基因的可变剪接转录物变体。[RefSeq 提供，2012 年 10 月]

This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012]

CNOT9 基因产物(3)

mRNA	Protein	Name
NM_001271634.2	NP_001258563.1	CCR4-NOT transcription complex subunit 9 isoform 1
NM_001271635.2	NP_001258564.1	CCR4-NOT transcription complex subunit 9 isoform 3
NM_005444.3	NP_005435.1	CCR4-NOT transcription complex subunit 9 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables epidermal growth factor receptor binding	IPI IPI: 通过物理相互作用推断	20878056	GOA
enables kinase binding	IPI IPI: 通过物理相互作用推断	20878056	GOA
enables nuclear receptor coactivator activity	IDA IDA: 通过直接分析推断	18180299	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	18180299	GOA
enables protein domain specific binding	IPI IPI: 通过物理相互作用推断	24768540	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	24768540	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of intracellular estrogen receptor signaling pathway	IMP IMP: 通过突变表型推断	16778766	GOA
involved in positive regulation of epidermal growth factor receptor signaling pathway	IMP IMP: 通过突变表型推断	20878056	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: 通过突变表型推断	20878056	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of CCR4-NOT complex	IDA IDA: 通过直接分析推断	19558367	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	20878056	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CNOT9 蛋白结构

Rcd1

0
100
200
299 a.a.

蛋白主名

其他名称

CCR4-NOT transcription complex subunit 9

RCD1 required for cell differentiation1 homolog

CNOT9 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CNOT9	Q92600	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	17452450

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Suppression Of Tumorigenicity 12

Prostate Adenocarcinoma	Adenocarcinoma Of Prostate
ST12	Prostate Adenocarcinoma 1
Pac1

Skin Melanoma

Cutaneous Melanoma	Malignant Ear Melanoma
Malignant Lip Melanoma	Malignant Lower Limb Melanoma
Malignant Melanoma Of Ear And/Or External Auricular Canal	Malignant Melanoma Of Skin Of Lower Limb
Malignant Melanoma Of Skin Of Trunk Except Scrotum	Malignant Melanoma Of Skin Of Upper Limb
Malignant Neck Melanoma	Malignant Scalp Melanoma
Malignant Trunk Melanoma	Malignant Upper Limb Melanoma
Melanoma, Cutaneous Malignant	Melanoma
Malignant Melanoma Of Skin	Melanoma Nos
Malignant Mole, Meaning Melanoma Of Unspecified Site	Melanoma Of Unspecified Site
Cutaneous Malignant Melanoma	Mm - [Malignant Melanoma]

Gastric Adenocarcinoma

Adenocarcinoma Of Stomach	Stomach Adenocarcinoma
Adenocarcinoma Gastric	Intestinal Type Adenocarcinoma Of Unspecified Site
Diffuse Type Adenocarcinoma Of Unspecified Site

Bladder Urothelial Carcinoma

Bladder Transitional Cell Carcinoma	Transitional Cell Carcinoma Of Bladder
Transitional Cell Carcinoma Of The Bladder	Urinary Bladder Urothelial Carcinoma
Urothelial Bladder Carcinoma	Carcinoma Transitional Cell Bladder
Tcc - [Transitional Cell Carcinoma] Of Bladder

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02909	CNOT9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	CNOT9	VGNC	VGNC:71165
Canis familiaris	CNOT9	VGNC	VGNC:39420
Mus musculus	CNOT9	MGD	MGI:1928902
Rattus norvegicus	CNOT9	RGD	RGD:1311495
Felis catus	CNOT9	VGNC	VGNC:80171
Bos taurus	CNOT9	VGNC	VGNC:27524
Others	CNOT9	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CNOT9 - CCR4-NOT transcription complex subunit 9 Gene

关于 CNOT9

功能概要

CNOT9 基因产物(3)

CNOT9 蛋白结构

CNOT9 蛋白互作信息

关联疾病

直系同源

热门区域

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CNOT9 - CCR4-NOT transcription complex subunit 9 Gene

关于 CNOT9

功能概要

CNOT9 基因产物(3)

CNOT9 蛋白结构

CNOT9 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z