2. Gene
  3. MAP4K4 - mitogen-activated protein kinase kinase kinase kinase 4 Gene

MAP4K4 - mitogen-activated protein kinase kinase kinase kinase 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：丝裂原活化蛋白激酶激酶激酶激酶 4

种属: Homo sapiens

同用名: HGK; NIK; MEKKK4; FLH21957; HEL-S-31

基因 ID: 9448 | 基因类型: protein coding

关于 MAP4K4

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:101,697,707-101,894,690 (from NCBI)

This gene has 18 transcripts (splice variants), 281 orthologues and 35 paralogues. Ubiquitous expression in brain (RPKM 42.7), fat (RPKM 25.1) and 23 other tissues.

功能概要

该基因编码的蛋白质是丝氨酸/苏氨酸蛋白激酶家族的成员。这种激酶已被证明可以特异性激活 MAPK8/JNK。发现该激酶对 MAPK8 的激活被 MAP3K7/TAK1、MAP2K4/MKK4 和 MAP2K7/MKK7 的显性失活突变体抑制，这表明该激酶可能通过 MAP3K7-MAP2K4-MAP2K7 激酶级联发挥作用，并且介导 TNF-α 信号通路。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

MAP4K4 基因产物(55)

mRNA Protein Name
NM_145686.4 NP_663719.2 mitogen-activated protein kinase kinase kinase kinase 4 isoform 2
NM_001384483.1 NP_001371412.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 11
NM_001384494.1 NP_001371423.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 22
NM_001384507.1 NP_001371436.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 28
NM_001384496.1 NP_001371425.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 24
NM_001384555.1 NP_001371484.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 42
NM_001384478.1 NP_001371407.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 8
NM_001384559.1 NP_001371488.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 46
NM_001384488.1 NP_001371417.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 16
NR_169282.1
NM_001384560.1 NP_001371489.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 47
NM_001384490.1 NP_001371419.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 18
NM_001384556.1 NP_001371485.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 43
NM_001384493.1 NP_001371422.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 21
NM_001384491.1 NP_001371420.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 19
NM_001384476.1 NP_001371405.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 6
NM_001384550.1 NP_001371479.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 37
NM_001384572.1 NP_001371501.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 53
NM_001384485.1 NP_001371414.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 13
NM_001384553.1 NP_001371482.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 40
NM_001384558.1 NP_001371487.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 45
NR_169280.1
NM_001384487.1 NP_001371416.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 15
NM_001384482.1 NP_001371411.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 10
NM_001384579.1 NP_001371508.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 54
NM_001395002.1 NP_001381931.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 55
NR_169279.1
NM_001384548.1 NP_001371477.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 35
NM_001384554.1 NP_001371483.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 41
NM_001384484.1 NP_001371413.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 12
NM_001384486.1 NP_001371415.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 14
NM_001384509.1 NP_001371438.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 30
NM_001384520.1 NP_001371449.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 31
NM_001384477.1 NP_001371406.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 7
NM_001384561.1 NP_001371490.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 48
NM_001384564.1 NP_001371493.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 51
NM_001384495.1 NP_001371424.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 23
NM_001384506.1 NP_001371435.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 27
NM_001384508.1 NP_001371437.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 29
NM_001384552.1 NP_001371481.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 39
NM_001384497.1 NP_001371426.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 25
NM_001242559.2 NP_001229488.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 4
NM_001384492.1 NP_001371421.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 20
NM_001384549.1 NP_001371478.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 36
NM_001242560.2 NP_001229489.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 5
NM_001384543.1 NP_001371472.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 32
NM_001384567.1 NP_001371496.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 52
NM_004834.5 NP_004825.3 mitogen-activated protein kinase kinase kinase kinase 4 isoform 1
NM_001384562.1 NP_001371491.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 49
NM_001384563.1 NP_001371492.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 50
NR_169281.1
NM_001384481.1 NP_001371410.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 9
NM_001384551.1 NP_001371480.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 38
NM_145687.4 NP_663720.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 3
NM_001384557.1 NP_001371486.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 44
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
9890973 GOA
enables MAP kinase kinase kinase kinase activity IDA
IDA: 通过直接分析推断
26437443 GOA
enables creatine kinase activity IDA
IDA: 通过直接分析推断
23207904 GOA
enables microtubule binding IDA
IDA: 通过直接分析推断
25490267 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12387898 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
9890973 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
9890973 GOA
NOT involved in microvillus assembly IMP
IMP: 通过突变表型推断
22797597 GOA
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
21196414 GOA
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
24163766 GOA
involved in positive regulation of hippo signaling IDA
IDA: 通过直接分析推断
26437443 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
9890973 GOA
involved in regulation of JNK cascade IDA
IDA: 通过直接分析推断
14966141 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasm IDA
IDA: 通过直接分析推断
26437443 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
14966141 GOA
located in focal adhesion IDA
IDA: 通过直接分析推断
25490267 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAP4K4 蛋白结构

Pkinase

Pkinase: Protein kinase domain (25 - 289)

CNH

CNH: CNH domain (931 - 1209)

  • 0
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  • 1000
  • 1239 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase kinase kinase kinase 4

HPK/GCK-like kinase HGK

MAPK/ERK kinase kinase kinase 4

MEK kinase kinase 4

Ste20 group protein kinase HGK

epididymis secretory protein Li 31

hepatocyte progenitor kinase-like/germinal center kinase-like kinase

nck-interacting kinase

MAP4K4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MAP4K4 O95819 GBP3 Homo sapiens Q9H0R5
Anti Tag CoIP
12387898
种属间: 跨种属相互作用 种属内: 同种属相互作用

MAP4K4 抗体

目录号 产品名 应用 反应物种
HY-P81378 MAP4K4/NIK Antibody (YA1123) IHC-P Human

关联疾病

疾病名称 别名
Hyperpigmentation With Or Without Hypopigmentation, Familial Progressive

FPHH

Melanosis Universalis Hereditaria

Muh

Familial Progressive Hyperpigmentation With Or Without Hypopigmentation

Hyperpigmentation, Familial Progressive, 2, Formerly

Fph2, Formerly

Hyperpigmentation With Or Without Hypopigmentation

Familial Progressive Hyper- And Hypopigmentation

Hyperpigmentation, Familial Progressive
Arteriovenous Malformations Of The Brain

Cerebral Arteriovenous Malformation

Intracranial Arteriovenous Malformation

Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To

Intracranial Arteriovenous Malformations

Bavm

Cerebral Arteriovenous Malformations

Intracranial Hemorrhage In Brain Cerebrovascular Malformations

Arteriovenous Malformation Of The Brain, Somatic

Intracranial Avm

Arteriovenous Malformations Cerebral
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (14)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100343 GNE-495 Inhibitor 99.49% 否
HY-111754 DMX-5804 Inhibitor 99.83% 否
HY-19562 PF-06260933 Inhibitor 99.67% 否
HY-160623 INS018 055 Inhibitor 99.38% 否
HY-132290 TGFβRI-IN-3 Inhibitor 98.21% 否
HY-125012 MAP4K4-IN-3 Inhibitor 99.15% 否
HY-U00428A GNE 220 hydrochloride Inhibitor 98.22% 否
HY-U00428 GNE 220 Inhibitor / 否
HY-156523 TNIK&MAP4K4-IN-1 / 否
HY-162922 MAP4K4-IN-6 Inhibitor / 否
HY-RS08080 MAP4K4 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08081 Map4k4 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08082 Map4k4 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-19562A PF-06260933 hydrochloride Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus MAP4K4 VGNC VGNC:81118
Mus musculus MAP4K4 MGD MGI:1349394
Bos taurus MAP4K4 VGNC VGNC:31207
Rattus norvegicus MAP4K4 RGD RGD:1305322
Canis familiaris MAP4K4 VGNC VGNC:42984
Macaca mulatta MAP4K4 VGNC VGNC:81467
Others MAP4K4 NCBI
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