2. Gene
  3. GBP3 - guanylate binding protein 3 Gene

GBP3 - guanylate binding protein 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：鸟苷酸结合蛋白 3

种属: Homo sapiens

基因 ID: 2635 | 基因类型: protein coding

关于 GBP3

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:89,006,680-89,022,866 (from NCBI)

This gene has 11 transcripts (splice variants), 42 orthologues and 10 paralogues. Broad expression in duodenum (RPKM 41.6), small intestine (RPKM 35.5) and 23 other tissues.

功能概要

该基因编码鸟苷酸结合蛋白 (GBP) 家族的成员。 GBP 特异性结合鸟嘌呤核苷酸 (GMP、GDP 和 GTP) 并包含典型 GTP 结合蛋白中发现的三个共有基序中的两个。编码的蛋白质与生发中心激酶家族的成员相互作用。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2017 年 1 月]

This gene encodes a member of the guanylate-binding protein (GBP) family. GBPs specifically bind guanine nucleotides (GMP, GDP, and GTP) and contain two of the three consensus motifs found in typical GTP-binding proteins. The encoded protein interacts with a member of the germinal center kinase family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2017]

GBP3 基因产物(4)

mRNA Protein Name
NM_001319179.2 NP_001306108.1 guanylate-binding protein 3 isoform 2
NM_001319180.2 NP_001306109.1 guanylate-binding protein 3 isoform 3
NM_001319181.2 NP_001306110.1 guanylate-binding protein 3 isoform 4
NM_018284.3 NP_060754.2 guanylate-binding protein 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
21151871 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12387898 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
21151871 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to interleukin-1 IEP
IEP: 通过表达模式推断
17266443 GOA
involved in cellular response to tumor necrosis factor IEP
IEP: 通过表达模式推断
17266443 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
17266443 GOA
located in cytosol IDA
IDA: 通过直接分析推断
21151871 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GBP3 蛋白结构

GBP

GBP: Guanylate-binding protein, N-terminal domain (19 - 280)

GBP_C

GBP_C: Guanylate-binding protein, C-terminal domain (282 - 578)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 595 a.a.
蛋白主名 其他名称

guanylate-binding protein 3

GTP-binding protein 3

GBP3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GBP3 Q9H0R5 MAP4K4 Homo sapiens O95819
Pull Down
12387898
种属内
GBP3 Q9H0R5 MAP4K4 Homo sapiens O95819
Y2H
12387898
种属内
GBP3 Q9H0R5 S100A10 Homo sapiens P60903
Crosslink
30021884
种属内
GBP3 Q9H0R5 tktA Francisella tularensis subsp. tularensis Q5NF74
Y2H Pooling
20711500
种属内
GBP3 Q9H0R5 GBP2 Homo sapiens P32456
Anti Tag CoIP
33961781
种属内
GBP3 Q9H0R5 ACTL6B Homo sapiens O94805
Anti Tag CoIP
33961781
种属内
GBP3 Q9H0R5 DECR2 Homo sapiens Q9NUI1
Anti Tag CoIP
33961781
种属内
GBP3 Q9H0R5 CASP6 Homo sapiens P55212
Anti Tag CoIP
33961781
种属内
GBP3 Q9H0R5 GBP3 Homo sapiens Q9H0R5
Y2H
21151871
种属内
GBP3 Q9H0R5 GBP3 Homo sapiens Q9H0R5
Anti Tag CoIP
21151871
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Orofacial Cleft 8

OFC8

Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 8

Non-Syndromic Cleft Lip/Palate 8

Non-Syndromic Cleft Lip With Or Without Cleft Palate 8

Orofacial Cleft, Type 8
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05309 GBP3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus GBP3 MGD MGI:95666
Rattus norvegicus GBP3 RGD RGD:1597766
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