2. Gene
  3. ATF7IP - activating transcription factor 7 interacting protein Gene

ATF7IP - activating transcription factor 7 interacting protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：激活转录因子 7 相互作用蛋白

种属: Homo sapiens

同用名: AM; MCAF; p621; MCAF1; ATF-IP; ATF7IP1

基因 ID: 55729 | 基因类型: protein coding

关于 ATF7IP

Cytogenetic location: 12p13.1 Genomic coordinates (GRCh38): 12:14,365,682-14,502,930 (from NCBI)

This gene has 24 transcripts (splice variants), 214 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 8.4), testis (RPKM 8.3) and 25 other tissues.

功能概要

ATF7IP 是一种与异染色质结合的多功能核蛋白。根据其结合伙伴，它可以充当转录共激活因子或辅抑制因子 (Liu 等人总结，2009 [PubMed 19106100]) 。[OMIM 提供，2010 年 11 月]

ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM, Nov 2010]

ATF7IP 基因产物(10)

mRNA Protein Name
NM_001286514.2 NP_001273443.1 activating transcription factor 7-interacting protein 1 isoform 3
NM_001286515.2 NP_001273444.1 activating transcription factor 7-interacting protein 1 isoform 4
NM_001388179.1 NP_001375108.1 activating transcription factor 7-interacting protein 1 isoform 5
NM_001388180.1 NP_001375109.1 activating transcription factor 7-interacting protein 1 isoform 2
NM_001388181.1 NP_001375110.1 activating transcription factor 7-interacting protein 1 isoform 2
NM_001388182.1 NP_001375111.1 activating transcription factor 7-interacting protein 1 isoform 2
NM_001388183.1 NP_001375112.1 activating transcription factor 7-interacting protein 1 isoform 2
NM_001388184.1 NP_001375113.1 activating transcription factor 7-interacting protein 1 isoform 3
NM_018179.5 NP_060649.3 activating transcription factor 7-interacting protein 1 isoform 2
NM_181352.2 NP_851997.1 activating transcription factor 7-interacting protein 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12665582 GOA
enables transcription coregulator activity IDA
IDA: 通过直接分析推断
12665582 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12665582 GOA
involved in positive regulation of DNA methylation-dependent heterochromatin formation IMP
IMP: 通过突变表型推断
27732843 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12665582 GOA
involved in protein stabilization IMP
IMP: 通过突变表型推断
27732843 GOA
involved in regulation of protein stability IMP
IMP: 通过突变表型推断
27732843 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
12665582 GOA
located in nucleus IMP
IMP: 通过突变表型推断
27732843 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

activating transcription factor 7-interacting protein 1

ATF-interacting protein

ATF7IP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ATF7IP Q6VMQ6 ARL14EP Homo sapiens Q8N8R7
Anti Tag CoIP
33961781
Intra ATF7IP Q6VMQ6 GTF2IRD1 Homo sapiens Q9UHL9
Y2H
26275350
Intra ATF7IP Q6VMQ6 DISC1 Homo sapiens Q9NRI5
Y2H
12812986
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Liver Carcinoma In Situ

Carcinoma In Situ Of Liver And Biliary System

Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts
Optic Atrophy 11

OPA11

Atrophy, Optic, Type 11
Uterine Corpus Endometrial Carcinoma
Testicular Germ Cell Cancer

Germ Cell Tumor Of Testis

Testicular Germ Cell Tumor

Testicular Germ Cell Neoplasm

Testicular Malignant Germ Cell Tumor
Alpha Thalassemia-Intellectual Disability Syndrome Type 1

Alpha Thalassemia-Intellectual Disability Syndrome, Deletion Type

Alpha-Thalassemia-Intellectual Disability Syndrome Linked To Chromosome 16

Atr Syndrome Linked To Chromosome 16

Atr Syndrome, Deletion Type

Atr-16 Syndrome

Alpha Thalassemia-Retardation Syndrome

Alpha-Thalassemia/Mental Retardation Syndrome, Deletion-Type

Alpha-Thalassemia/Mental Retardation Syndrome, Type 1

Alpha-Thalassemia Mental Retardation Syndrome, Deletion-Type
Testicular Disease

Testicular Dysfunction

Testicular Diseases

Disorder Of Testis

Testis Disorder

Testicular Disorders
Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism

Undescended Testicle

Undescended Testis

Cryptorchism

Undescended Testicles

CRYPTO

Impaired Testicular Descent

Cryptosporidiosis

Retained Testis

Unilateral Cryptorchidism

Unilateral Undescended Testis

Nondescent Unilateral Testicle

Unilateral Cryptorchism

Ectopic Testis, Unilateral

Bilateral Cryptorchidism

Bilateral Cryptorchism

Bilateral Nondescent Testicle

Bilateral Undescended Testes

Bilateral Ectopic Testes
Testicular Cancer

Testis Cancer

Testicular Carcinoma

Testicular Neoplasms

Malignant Neoplasm Of Testis

Childhood Neoplasm Of The Testis

Neoplasm Of Testis

Pediatric Testicular Neoplasm

Testicular Tumor

Testis Neoplasm

Testicular Tumors

Testicular Neoplasm

Testicular Malignant Germ Cell Tumor

Childhood Testicular Neoplasm

Carcinoma Of The Testis

Cancer Of Testis

Malignant Neoplasm Of Testis, Nos

Malignant Neoplasm Of Testis, Unspecified

Malignant Tumour Of Testis

Testicle Cancer

Primary Malignant Neoplasm Of Testis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01137 ATF7IP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ATF7IP MGD MGI:1858965
Felis catus ATF7IP VGNC VGNC:59994
Macaca mulatta ATF7IP VGNC VGNC:70100
Bos taurus ATF7IP VGNC VGNC:26246
Canis familiaris ATF7IP VGNC VGNC:38213
Rattus norvegicus ATF7IP RGD RGD:1306030
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