1. Gene
  2. XRN2 - 5'-3' exoribonuclease 2 Gene

XRN2 - 5'-3' exoribonuclease 2 Gene

中文名称:5'-3' 核糖核酸外切酶 2

种属: Homo sapiens

基因 ID: 22803 | 基因类型: protein coding

关于 XRN2

Cytogenetic location: 20p11.22 Genomic coordinates (GRCh38): 20:21,303,331-21,389,825 (from NCBI)

This gene has 1 transcript (splice variant), 212 orthologues and 1 paralogue. Ubiquitous expression in appendix (RPKM 21.1), thyroid (RPKM 20.8) and 25 other tissues.

功能概要

该基因编码一种 5'-3' 核酸外切酶,可促进转录在共转录切割位点的终止。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供,2015 年 12 月]

This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

XRN2 基因产物(2)

mRNA Protein Name
NM_001317960.1 NP_001304889.1 5'-3' exoribonuclease 2 isoform 1
NM_012255.5 NP_036387.2 5'-3' exoribonuclease 2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3'-5'-RNA exonuclease activity EXP
EXP: 通过实验结果推断
23482395 GOA
enables 5'-3' exonuclease activity IDA
IDA: 通过直接分析推断
15565158 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15231747 GOA
enables transcription termination site sequence-specific DNA binding IDA
IDA: 通过直接分析推断
21700224 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in spermatogenesis IEP
IEP: 通过表达模式推断
10409438 GOA
involved in termination of RNA polymerase II transcription IMP
IMP: 通过突变表型推断
15565158 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleolus IDA
IDA: 通过直接分析推断
12429849 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

XRN2 蛋白结构

XRN_N

XRN_N: XRN 5'-3' exonuclease N-terminus (1 - 255)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 950 a.a.
蛋白主名 其他名称

5'-3' exoribonuclease 2

DHM1-like protein

XRN2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
XRN2 Q9H0D6 CDKN2AIPNL Homo sapiens Q96HQ2
Anti Tag CoIP
34591612
种属内
XRN2 Q9H0D6 LCN2 Homo sapiens P80188
Y2H Prey Pooling
32296183
种属内
XRN2 Q9H0D6 LCN2 Homo sapiens P80188
Y2H Array
32296183
种属内
XRN2 Q9H0D6 CDKN2AIP Homo sapiens Q9NXV6
Anti Tag CoIP
34591612
种属内
XRN2 Q9H0D6 DISC1 Homo sapiens Q9NRI5
Y2H
17043677
种属内
XRN2 Q9H0D6 TARDBP Homo sapiens Q13148
Y2H
15231747
种属内
XRN2 Q9H0D6 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Amyotrophic Lateral Sclerosis 4, Juvenile

Amyotrophic Lateral Sclerosis Type 4

ALS4

Amyotrophic Lateral Sclerosis 4

Dhmn With Upper Motor Neuron Signs

Distal Hereditary Motor Neuropathy With Upper Motor Neuron Signs

Neuronopathy, Distal Hereditary Motor, With Pyramidal Features

Als 4

Distal Hereditary Motor Neuropathy With Pyramidal Features

Amyotrophic Lateral Sclerosis Juvenile 4

Neuronopathy Distal Hereditary Motor With Pyramidal Features

Sclerosis, Lateral, Amyotrophic, Type Type 4

Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 2

Aoa2

Ataxia With Oculomotor Apraxia Type 2

Scar1

SCAN2

Ataxia-Oculomotor Apraxia 2

Ataxia-Ocular Apraxia 2

Ataxia-Oculomotor Apraxia Type 2

Scan 2

Spinocerebellar Ataxia With Axonal Neuropathy Type 2

Spinocerebellar Ataxia, Autosomal Recessive 1, Formerly

Scar1, Formerly

Autosomal Recessive Spinocerebellar Ataxia-1

Spinocerebellar Ataxia, Autosomal Recessive, 1

Ataxia-Ocular Apraxia-2

Spinocerebellar Ataxia, Autosomal Recessive 1

Corneal Dystrophy, Posterior Polymorphous, 1

Posterior Polymorphous Corneal Dystrophy

Ppcd

Maumenee Corneal Dystrophy

Posterior Polymorphous Corneal Dystrophy 1

PPCD1

Corneal Dystrophy, Hereditary Polymorphous Posterior

Corneal Endothelial Dystrophy 1, Autosomal Dominant

Schlichting Dystrophy

Ched1

Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly

Ched1, Formerly

Hereditary Polymorphus Posterior Corneal Dystrophy

Posterior Polymorphous Dystrophy

Hereditary Polymorphous Posterior Corneal Dystrophy

Dystrophy, Corneal, Posterior Polymorphous

Dystrophy, Corneal, Posterior Polymorphous, Type 1

Polymorphous Corneal Dystrophy

Corneal Endothelial Dystrophy 2

Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta XRN2 VGNC VGNC:78814
Rattus norvegicus XRN2 RGD RGD:1310218
Felis catus XRN2 VGNC VGNC:67123
Mus musculus XRN2 MGD MGI:894687
Canis familiaris XRN2 VGNC VGNC:48472
Bos taurus XRN2 VGNC VGNC:37009