2. Gene
  3. GOLGA1 - golgin A1 Gene

GOLGA1 - golgin A1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：高金 A1

种属: Homo sapiens

同用名: golgin-97

基因 ID: 2800 | 基因类型: protein coding

关于 GOLGA1

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:124,878,275-124,948,043 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 12.9), skin (RPKM 6.1) and 25 other tissues.

功能概要

参与分泌途径中蛋白质和脂质的糖基化和转运的高尔基体由一系列堆叠的池 (扁平膜囊) 组成。高尔基体和微管之间的相互作用被认为对于高尔基体在有丝分裂过程中断裂后的重组很重要。该基因编码一种 golgins，这是一个定位于高尔基体的蛋白质家族。这种编码的蛋白质与干燥综合征有关。[RefSeq 提供，2010 年 2 月]

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein is associated with Sjogren's syndrome. [provided by RefSeq, Feb 2010]

GOLGA1 基因产物(1)

mRNA Protein Name
NM_002077.4 NP_002068.2 golgin subfamily A member 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
17724343 GOA
located in trans-Golgi network IDA
IDA: 通过直接分析推断
17488291 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GOLGA1 蛋白结构

GRIP

GRIP: GRIP domain (692 - 734)

  • 0
  • 200
  • 400
  • 600
  • 767 a.a.
蛋白主名 其他名称

golgin subfamily A member 1

gap junction protein, alpha 4, 37kD

GOLGA1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra GOLGA1 Q92805 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra GOLGA1 Q92805 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra GOLGA1 Q92805 CEP57L1 Homo sapiens Q8IYX8-2
Validated Y2H
25416956
Intra GOLGA1 Q92805 ZNF774 Homo sapiens Q6NX45
Y2H Array
32296183
Intra GOLGA1 Q92805 ZNF774 Homo sapiens Q6NX45
Y2H Prey Pooling
32296183
Intra GOLGA1 Q92805 SLAIN1 Homo sapiens Q8ND83
Y2H Array
32296183
Intra GOLGA1 Q92805 SLAIN1 Homo sapiens Q8ND83
Y2H Prey Pooling
32296183
Intra GOLGA1 Q92805 PPP1R13B Homo sapiens Q96KQ4
Y2H Prey Pooling
32296183
Intra GOLGA1 Q92805 PPP1R13B Homo sapiens Q96KQ4
Validated Y2H
32296183
Intra GOLGA1 Q92805 PPP1R13B Homo sapiens Q96KQ4
Y2H Array
32296183
Intra GOLGA1 Q92805 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
25416956
Intra GOLGA1 Q92805 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra GOLGA1 Q92805 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra GOLGA1 Q92805 TFIP11 Homo sapiens Q9UBB9
Y2H Array
25416956
Intra GOLGA1 Q92805 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra GOLGA1 Q92805 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra GOLGA1 Q92805 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra GOLGA1 Q92805 LZTS1 Homo sapiens Q9Y250
Y2H Prey Pooling
32296183
Intra GOLGA1 Q92805 LZTS1 Homo sapiens Q9Y250
Validated Y2H
32296183
Intra GOLGA1 Q92805 LZTS1 Homo sapiens Q9Y250
Y2H Array
32296183
Intra GOLGA1 Q92805 KIFC3 Homo sapiens Q9BVG8-5
Y2H Prey Pooling
32296183
Intra GOLGA1 Q92805 KIFC3 Homo sapiens Q9BVG8-5
Y2H Array
32296183
Intra GOLGA1 Q92805 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra GOLGA1 Q92805 ZC2HC1C Homo sapiens Q53FD0-2
Y2H Prey Pooling
32296183
Intra GOLGA1 Q92805 ZC2HC1C Homo sapiens Q53FD0-2
Y2H Array
32296183
Intra GOLGA1 Q92805 EXOC4 Homo sapiens Q96A65-2
Y2H Array
32296183
Intra GOLGA1 Q92805 EXOC4 Homo sapiens Q96A65-2
Y2H Prey Pooling
32296183
Intra GOLGA1 Q92805 EXOC4 Homo sapiens Q96A65-2
Validated Y2H
32296183
Intra GOLGA1 Q92805 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
32296183
Intra GOLGA1 Q92805 EFHC2 Homo sapiens Q5JST6
Y2H Array
32296183
Intra GOLGA1 Q92805 VPS52 Homo sapiens Q8N1B4
Validated Y2H
25416956
Intra GOLGA1 Q92805 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
32296183
Intra GOLGA1 Q92805 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
25416956
Intra GOLGA1 Q92805 VPS52 Homo sapiens Q8N1B4
Y2H Array
32296183
Intra GOLGA1 Q92805 PRKAR1B Homo sapiens P31321
Y2H Prey Pooling
32296183
Intra GOLGA1 Q92805 PRKAR1B Homo sapiens P31321
Y2H Array
32296183
Intra GOLGA1 Q92805 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra GOLGA1 Q92805 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra GOLGA1 Q92805 KIAA1328 Homo sapiens Q86T90
Y2H Prey Pooling
32296183
Intra GOLGA1 Q92805 KIAA1328 Homo sapiens Q86T90
Y2H Array
32296183
Intra GOLGA1 Q92805 ATF4 Homo sapiens P18848
Y2H Prey Pooling
32296183
Intra GOLGA1 Q92805 ATF4 Homo sapiens P18848
Y2H Array
25416956
Intra GOLGA1 Q92805 ATF4 Homo sapiens P18848
Y2H Array
32296183
Intra GOLGA1 Q92805 ATF4 Homo sapiens P18848
Y2H Prey Pooling
25416956
Intra GOLGA1 Q92805 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra GOLGA1 Q92805 HSF2BP Homo sapiens O75031
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Robinow Syndrome, Autosomal Dominant 1

Autosomal Dominant Robinow Syndrome 1

DRS1

Robinow Dwarfism

Fetal Face Syndrome

Acral Dysostosis With Facial And Genital Abnormalities

Robinow, Autosomal Dominant Syndrome, Type 1
Spastic Paraplegia 50, Autosomal Recessive

Hereditary Spastic Paraplegia 50

SPG50

Ap-4 Deficiency Syndrome

Ap-4-Associated Hereditary Spastic Paraplegia

Adaptor Protein Complex 4 Deficiency

Cerebral Palsy, Spastic Quadriplegic, 3, Formerly

Cpsq3, Formerly

Autosomal Recessive Spastic Paraplegia 50

Cpsq3

Spastic Quadriplegic Cerebral Palsy 3

Ap-4 Deficiency

Ap-4-Associated Hsp

Paraplegia, Spastic, Autosomal Recessive, Type 50

Spastic Paraplegia-50, Autosomal Recessive
Geroderma Osteodysplasticum

Gerodermia Osteodysplastica

Geroderma Osteodysplastica

GO

Walt Disney Dwarfism

Type Of Gerodermia Osteodysplastica
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05582 GOLGA1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris GOLGA1 VGNC VGNC:41338
Rattus norvegicus GOLGA1 RGD RGD:1311305
Bos taurus GOLGA1 VGNC VGNC:29483
Mus musculus GOLGA1 MGD MGI:1924149
Felis catus GOLGA1 VGNC VGNC:62637
Macaca mulatta GOLGA1 VGNC VGNC:82151
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