1. Gene
  2. DDX25 - DEAD-box helicase 25 Gene

DDX25 - DEAD-box helicase 25 Gene

中文名称:死盒解旋酶 25

种属: Homo sapiens

同用名: GRTH

基因 ID: 29118 | 基因类型: protein coding

关于 DDX25

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:125,903,328-125,928,843 (from NCBI)

This gene has 10 transcripts (splice variants), 131 orthologues and 38 paralogues. Restricted expression toward testis (RPKM 40.9).

功能概要

以保守基序 Asp-Glu-Ala-Asp (DEAD) 为特征的 DEAD 盒蛋白是推定的 RNA 解旋酶。它们涉及许多涉及 RNA 二级结构改变的细胞过程,例如翻译起始、核和线粒体剪接以及核糖体和剪接体组装。根据它们的分布模式,DEAD box 蛋白家族的一些成员被认为参与胚胎发生、精子发生以及细胞生长和分裂。该基因编码该家族的一个成员。编码的蛋白质是促性腺激素调节和发育表达的睾丸 RNA 解旋酶。它可能有助于维持与类固醇生成和精子生成相关的睾丸功能。[RefSeq 提供,2008 年 7 月]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein is a gonadotropin-regulated and developmentally expressed testicular RNA helicase. It may serve to maintain testicular functions related to steroidogenesis and spermatogenesis. [provided by RefSeq, Jul 2008]

DDX25 基因产物(2)

mRNA Protein Name
NM_001330438.2 NP_001317367.1 ATP-dependent RNA helicase DDX25 isoform 2
NM_013264.5 NP_037396.3 ATP-dependent RNA helicase DDX25 isoform 1

DDX25 蛋白结构

DEAD

DEAD: DEAD/DEAH box helicase (122 - 284)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (359 - 439)

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  • 483 a.a.
蛋白主名 其他名称

ATP-dependent RNA helicase DDX25

DEAD (Asp-Glu-Ala-Asp) box helicase 25

关联疾病

疾病名称 别名
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus DDX25 RGD RGD:68381
Macaca mulatta DDX25 VGNC VGNC:71666
Canis familiaris DDX25 VGNC VGNC:39852
Mus musculus DDX25 MGD MGI:1353582
Felis catus DDX25 VGNC VGNC:61403
Bos taurus DDX25 VGNC VGNC:27961