2. Gene
  3. CTDSP1 - CTD small phosphatase 1 Gene

CTDSP1 - CTD small phosphatase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：CTD 小磷酸酶 1

种属: Homo sapiens

同用名: NIF3; SCP1; NLIIF; NLI-IF

基因 ID: 58190 | 基因类型: protein coding

关于 CTDSP1

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,396,351-218,405,941 (from NCBI)

This gene has 15 transcripts (splice variants), 256 orthologues and 5 paralogues. Ubiquitous expression in placenta (RPKM 26.9), ovary (RPKM 24.5) and 25 other tissues.

功能概要

该基因编码核磷酸酶的小 C 端结构域磷酸酶 (SCP) 家族的成员。这些蛋白质通过对 RNA 聚合酶 II 的 C 末端结构域的串联七肽重复序列内的磷酸丝氨酸 5 进行特异性去磷酸化，在转录调节中发挥作用。编码的蛋白质在非神经元细胞的神经元基因沉默中发挥作用，也可能抑制成骨细胞分化。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 10 月]

This gene encodes a member of the small C-terminal domain Phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

CTDSP1 基因产物(12)

mRNA Protein Name
NM_001206878.2 NP_001193807.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 3
NM_001400268.1 NP_001387197.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 2
NM_001400269.1 NP_001387198.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 4
NM_001400270.1 NP_001387199.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 5
NM_001400271.1 NP_001387200.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 6
NM_001400272.1 NP_001387201.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 7
NM_001400273.1 NP_001387202.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 8
NM_001400274.1 NP_001387203.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 9
NM_001400275.1 NP_001387204.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 10
NM_001400276.1 NP_001387205.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 11
NM_021198.3 NP_067021.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1
NM_182642.3 NP_872580.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IDA
IDA: 通过直接分析推断
12721286 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12721286 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein dephosphorylation IDA
IDA: 通过直接分析推断
12721286 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12721286 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
12721286 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CTDSP1 蛋白结构

NIF

NIF: NLI interacting factor-like phosphatase (92 - 250)

  • 0
  • 100
  • 200
  • 261 a.a.
蛋白主名 其他名称

carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1

CTDSP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CTDSP1 Q9GZU7 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
Intra CTDSP1 Q9GZU7 SMAD1 Homo sapiens Q15797
Anti Tag CoIP
16882717
Intra CTDSP1 Q9GZU7 FANCL Homo sapiens Q9NW38
Validated Y2H
32296183
Cross CTDSP1 Q9GZU7 Ctdsp1 Mus musculus P58466
Anti Bait CoIP
14743429
Intra CTDSP1 Q9GZU7 CDCA3 Homo sapiens Q99618
Anti Tag CoIP
33961781
Intra CTDSP1 Q9GZU7 CDCA3 Homo sapiens Q99618
Anti Tag CoIP
27880917
Intra CTDSP1 Q9GZU7 CDCA3 Homo sapiens Q99618
Y2H Pooling
16189514
Intra CTDSP1 Q9GZU7 CDCA3 Homo sapiens Q99618
Anti Tag CoIP
28514442
Intra CTDSP1 Q9GZU7 CDCA3 Homo sapiens Q99618
Y2H Prey Pooling
25416956
Intra CTDSP1 Q9GZU7 CDCA3 Homo sapiens Q99618
Validated Y2H
25416956
Intra CTDSP1 Q9GZU7 CDCA3 Homo sapiens Q99618
Y2H Array
25416956
Intra CTDSP1 Q9GZU7 CSTF2T Homo sapiens Q9H0L4
Validated Y2H
32296183
Intra CTDSP1 Q9GZU7 MBP Homo sapiens P02686
Y2H Prey Pooling
25416956
Intra CTDSP1 Q9GZU7 MBP Homo sapiens P02686
Y2H Array
25416956
Intra CTDSP1 Q9GZU7 MBP Homo sapiens P02686
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03291 CTDSP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CTDSP1 VGNC VGNC:39693
Felis catus CTDSP1 VGNC VGNC:61247
Rattus norvegicus CTDSP1 RGD RGD:1305629
Mus musculus CTDSP1 MGD MGI:2654470
Macaca mulatta CTDSP1 VGNC VGNC:71448
Bos taurus CTDSP1 VGNC VGNC:27790
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