TRIP12 - thyroid hormone receptor interactor 12 Gene

中文名称：甲状腺激素受体相互作用因子 12

种属: Homo sapiens

同用名: ULF; MRD49; TRIPC; TRIP-12

基因 ID: 9320 | 基因类型: protein coding

关于 TRIP12

Cytogenetic location: 2q36.3 Genomic coordinates (GRCh38): 2:229,763,837-229,923,186 (from NCBI)

This gene has 30 transcripts (splice variants), 215 orthologues, 24 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 48.5), thyroid (RPKM 17.6) and 24 other tissues.

功能概要

该基因编码的蛋白质是一种 E3 泛素蛋白连接酶，参与肿瘤抑制因子 CDKN2A 的 p19ARF/ARF 亚型的降解。编码的蛋白质还通过调节 USP7 的稳定性在 DNA 损伤反应中发挥作用，USP7 调节肿瘤抑制因子 p53。[RefSeq 提供，2017 年 1 月]

The protein encoded by this gene is an E3 ubiquitin-protein Ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]

TRIP12 基因产物(26)

mRNA	Protein	Name
NM_001284214.2	NP_001271143.1	E3 ubiquitin-protein ligase TRIP12 isoform a
NM_001284215.2	NP_001271144.1	E3 ubiquitin-protein ligase TRIP12 isoform b
NM_001284216.2	NP_001271145.1	E3 ubiquitin-protein ligase TRIP12 isoform d
NM_001348315.2	NP_001335244.1	E3 ubiquitin-protein ligase TRIP12 isoform a
NM_001348316.2	NP_001335245.1	E3 ubiquitin-protein ligase TRIP12 isoform b
NM_001348317.1	NP_001335246.1	E3 ubiquitin-protein ligase TRIP12 isoform e
NM_001348318.2	NP_001335247.1	E3 ubiquitin-protein ligase TRIP12 isoform e
NM_001348319.1	NP_001335248.1	E3 ubiquitin-protein ligase TRIP12 isoform f
NM_001348320.2	NP_001335249.1	E3 ubiquitin-protein ligase TRIP12 isoform f
NM_001348321.1	NP_001335250.1	E3 ubiquitin-protein ligase TRIP12 isoform g
NM_001348322.1	NP_001335251.1	E3 ubiquitin-protein ligase TRIP12 isoform h
NM_001348323.3	NP_001335252.1	E3 ubiquitin-protein ligase TRIP12 isoform h
NM_001348324.2	NP_001335253.1	E3 ubiquitin-protein ligase TRIP12 isoform h
NM_001348325.2	NP_001335254.1	E3 ubiquitin-protein ligase TRIP12 isoform h
NM_001348326.2	NP_001335255.1	E3 ubiquitin-protein ligase TRIP12 isoform h
NM_001348327.2	NP_001335256.1	E3 ubiquitin-protein ligase TRIP12 isoform h
NM_001348328.1	NP_001335257.1	E3 ubiquitin-protein ligase TRIP12 isoform i
NM_001348329.2	NP_001335258.1	E3 ubiquitin-protein ligase TRIP12 isoform i
NM_001348330.2	NP_001335259.1	E3 ubiquitin-protein ligase TRIP12 isoform i
NM_001348331.1	NP_001335260.1	E3 ubiquitin-protein ligase TRIP12 isoform j
NM_001348332.1	NP_001335261.1	E3 ubiquitin-protein ligase TRIP12 isoform k
NM_001348333.1	NP_001335262.1	E3 ubiquitin-protein ligase TRIP12 isoform l
NM_001348334.1	NP_001335263.1	E3 ubiquitin-protein ligase TRIP12 isoform n
NM_001348335.2	NP_001335264.1	E3 ubiquitin-protein ligase TRIP12 isoform m
NM_001348336.1	NP_001335265.1	E3 ubiquitin-protein ligase TRIP12 isoform m
NM_004238.3	NP_004229.1	E3 ubiquitin-protein ligase TRIP12 isoform c

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables nuclear thyroid hormone receptor binding	IDA IDA: 通过直接分析推断	7776974	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	18627766	GOA
enables ubiquitin protein ligase activity	IDA IDA: 通过直接分析推断	18627766	GOA
enables ubiquitin protein ligase activity	IMP IMP: 通过突变表型推断	19028681	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA repair-dependent chromatin remodeling	IMP IMP: 通过突变表型推断	22884692	GOA
involved in heterochromatin boundary formation	IMP IMP: 通过突变表型推断	22884692	GOA
involved in protein polyubiquitination	IDA IDA: 通过直接分析推断	30982744	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	18627766	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	19028681	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleoplasm	IDA IDA: 通过直接分析推断	20208519	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRIP12 蛋白结构

HECT

0
400
800
1200
1600
1992 a.a.

蛋白主名

其他名称

E3 ubiquitin-protein ligase TRIP12

E3 ubiquitin-protein ligase for Arf

TRIP12 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TRIP12	Q14669	MTNR1B	Homo sapiens	P49286	Y2H	26514267
种属内	TRIP12	Q14669	NPM1	Homo sapiens	P06748-1	Anti Tag CoIP	20208519
种属内	TRIP12	Q14669	MYC	Homo sapiens	P01106	Anti Bait CoIP	20208519
种属内	TRIP12	Q14669	MYC	Homo sapiens	P01106	Pull Down	20208519
种属内	TRIP12	Q14669	MYC	Homo sapiens	P01106	Anti Tag CoIP	20208519
种属内	TRIP12	Q14669	CDKN2A	Homo sapiens	Q8N726	Pull Down	20208519
种属内	TRIP12	Q14669	CDKN2A	Homo sapiens	Q8N726	Anti Bait CoIP	20208519
种属内	TRIP12	Q14669	CDKN2A	Homo sapiens	Q8N726	Anti Tag CoIP	20208519

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Clark-Baraitser Syndrome

CLABARS	Baraitser Syndrome
Autosomal Dominant Intellectual Disability 49	Mental Retardation, Autosomal Dominant 49, Formerly
Mrd49, Formerly	Intellectual Developmental Disorder, Autosomal Dominant 49
Autosomal Dominant Mental Retardation 49	Intellectual Disability, Tall Stature, Obesity, Macrocephaly And Typical Facial Features
Mrd49	Progeria Short Stature Pigmented Nevi

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Developmental And Epileptic Encephalopathy 17

DEE17	Epileptic Encephalopathy, Early Infantile, 17
Eiee17	Developmental And Epileptic Encephalopathy, 17
Early Infantile Epileptic Encephalopathy 17	Developmental And Epileptic Encephalopathy, Type 17

Thyroid Dyshormonogenesis 1

TDH1	Hypothyroidism, Congenital, Due To Dyshormonogenesis, 1
Genetic Defect In Thyroid Hormonogenesis 1	Thyroid Hormonogenesis, Genetic Defect In, 1
Iodine Accumulation, Transport, Or Trapping Defect	Iodide Accumulation, Transport, Or Trapping Defect
Chdh1	Congenital Hypothyroidism Due To Dyshormonogenesis Type 1
Iodine Accumulation, Transport Or Trapping Defect

Alternating Exotropia

Exotropia

Anal Squamous Cell Carcinoma

Epidermoid Anal Carcinoma

Carcinoma Of Anal Margin

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15078	TRIP12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	TRIP12	VGNC	VGNC:99414
Rattus norvegicus	TRIP12	RGD	RGD:1306607
Mus musculus	TRIP12	MGD	MGI:1309481
Canis familiaris	TRIP12	VGNC	VGNC:47845
Bos taurus	TRIP12	VGNC	VGNC:36358
Felis catus	TRIP12	VGNC	VGNC:66560

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TRIP12 - thyroid hormone receptor interactor 12 Gene

关于 TRIP12

功能概要

TRIP12 基因产物(26)

TRIP12 蛋白结构

TRIP12 蛋白互作信息

关联疾病

直系同源

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TRIP12 - thyroid hormone receptor interactor 12 Gene

关于 TRIP12

功能概要

TRIP12 基因产物(26)

TRIP12 蛋白结构

TRIP12 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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Z