2. Gene
  3. SLAMF6 - SLAM family member 6 Gene

SLAMF6 - SLAM family member 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SLAM 家族成员 6

种属: Homo sapiens

同用名: KALI; NTBA; CD352; KALIb; Ly108; NTB-A; SF2000

基因 ID: 114836 | 基因类型: protein coding

关于 SLAMF6

Cytogenetic location: 1q23.2-q23.3 Genomic coordinates (GRCh38): 1:160,485,036-160,523,255 (from NCBI)

This gene has 3 transcripts (splice variants), 132 orthologues and 9 paralogues. Biased expression in lymph node (RPKM 29.2), spleen (RPKM 15.5) and 7 other tissues.

功能概要

该基因编码的蛋白是 I 型跨膜蛋白，属于免疫球蛋白超家族的 CD2 亚家族。这种编码的蛋白质在自然杀伤 (NK) 、T 和 B 淋巴细胞上表达。它经历酪氨酸磷酸化并与含有 Src 同源 2 结构域的蛋白 (SH2D1A) 以及含有 SH2 结构域的磷酸酶 (SHP) 结合。它在 NK 细胞活化过程中起辅助受体的作用。它还可以介导来自 X 连锁淋巴增生患者的 NK 细胞中的抑制信号。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2010 年 5 月]

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

SLAMF6 基因产物(4)

mRNA Protein Name
NM_001184714.2 NP_001171643.1 SLAM family member 6 isoform 1 precursor
NM_001184715.2 NP_001171644.1 SLAM family member 6 isoform 3 precursor
NM_001184716.2 NP_001171645.1 SLAM family member 6 isoform 4 precursor
NM_052931.5 NP_443163.1 SLAM family member 6 isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11489943 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T-helper 17 cell lineage commitment IDA
IDA: 通过直接分析推断
22184727 GOA
involved in positive regulation of interleukin-17 production IDA
IDA: 通过直接分析推断
22184727 GOA
involved in positive regulation of natural killer cell mediated cytotoxicity IDA
IDA: 通过直接分析推断
16920955 GOA
involved in positive regulation of type II interferon production IMP
IMP: 通过突变表型推断
16920955 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
22184727 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLAMF6 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (27 - 114)

Ig_3

Ig_3: Immunoglobulin domain (143 - 199)

  • 0
  • 100
  • 200
  • 300
  • 332 a.a.
蛋白主名 其他名称

SLAM family member 6

NK-T-B-antigen

SLAMF6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SLAMF6 Q96DU3 SH2D1B Homo sapiens O14796
Anti Bait CoIP
16920955
种属内
SLAMF6 Q96DU3 SH2D1B Homo sapiens O14796
Anti Bait CoIP
23346089
种属内
SLAMF6 Q96DU3 SH2D1A Homo sapiens O60880
Pull Down
22912825
种属内
SLAMF6 Q96DU3 SH2D1A Homo sapiens O60880
Anti Bait CoIP
16920955
种属内
SLAMF6 Q96DU3 SH2D1A Homo sapiens O60880
Anti Bait CoIP
23346089
种属内
SLAMF6 Q96DU3 SH2D1A Homo sapiens O60880
Anti Bait CoIP
11489943
种属内
SLAMF6 Q96DU3 SH2D1A Homo sapiens O60880
Anti Bait CoIP
24688028
种属内
SLAMF6 Q96DU3 RABAC1 Homo sapiens Q9UI14
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SLAMF6 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71317 SLAMF6 Protein, Human (HEK293, His) Q96DU3-1 (L28-K225) ≥95%
HY-P72415 SLAMF6 Protein, Human (HEK293, His-Avi) Q96DU3-1 (Q22-K225) ≥95%
HY-P76645 SLAMF6 Protein, Human (HEK293) Q96DU3-1 (Q22-M226) ≥95%
HY-P76646 SLAMF6 Protein, Human (HEK293, Fc) Q96DU3-1 (Q22-M226) ≥95%

SLAMF6 抗体

目录号 产品名 应用 反应物种
HY-P81727 NTB-A Antibody (YA1472) FC, ELISA Human
HY-P82232 SLAMF6 Antibody (YA1977) WB, ICC/IF, IP Human

关联疾病

疾病名称 别名
Selective Immunoglobulin Deficiency Disease
Lupus Erythematosus

Lupus

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus, Systemic

Subacute Cutaneous Lupus

Le - [Lupus Erythematosus]
Lymphoproliferative Syndrome

Lymphoproliferative Disorder

Lymphoproliferative Disorders

Lymphoproliferative Disorders, Susceptibility To
Dysgammaglobulinemia
Ovarian Cystic Teratoma
Lymphoproliferative Syndrome, X-Linked, 1

Lymphomatoid Papulosis

Duncan Disease

Purtilo Syndrome

X-Linked Lymphoproliferative Syndrome

Xlp

X-Linked Lymphoproliferative Disease

XLP1

Lyp

Lymphoproliferative Disease, X-Linked

Xlpd

X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency

Ebv Infection, Severe, Susceptibility To

Ebvs

Immunodeficiency 5

Imd5

X-Linked Lymphoproliferative Syndrome 1

Epstein-Barr Virus Infection, Familial Fatal

Ebv Infection, Severe

Infectious Mononucleosis, Severe

Infectious Mononucleosis, Severe, Susceptibility To

Immunodeficiency, X-Linked Progressive Combined Variable

Epstein Barr Virus Infection, Familial Fatal

X-Linked Progressive Combined Variable Immunodeficiency 5

Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males

Familial Fatal Epstein-Barr Infection

Severe Susceptibility To Ebv Infection

Severe Susceptibility To Infectious Mononucleosis

Sap Deficiency

Sh2d1a/Slam-Associated Protein Deficiency

X-Linked Lymphoproliferative Syndrome Type 1

X-Linked Progressive Combined Variable Immunodeficiency

Lymphoproliferative Syndrome, X-Linked

Sap

X-Linked Lymphoproliferative Disorder
Mature Teratoma Of The Ovary
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia

XMEN

X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia

X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia

Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia

Cid Due To Magt1 Deficiency

Combined Immunodeficiency Due To Magt1 Deficiency

X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection An

X-Linked Magnesium Deficiency With Epstein-Barr Virus Infection And Neoplasia
Lymphoproliferative Syndrome 2

Cd27 Deficiency

LPFS2

Combined Immunodeficiency Due To Cd27 Deficiency

Autosomal Recessive Lymphoproliferative Disease Due To Cd27 Deficiency
Pfeiffer Syndrome

Infectious Mononucleosis

Acs5

Craniofacial-Skeletal-Dermatologic Dysplasia

Acs V

Noack Syndrome

Gammaherpesviral Mononucleosis

Acrocephalosyndactyly Type 5

Pfeiffer Syndrome Type 3

Acrocephalosyndactyly, Type V

Glandular Fever

Pfeiffer Type Acrocephalosyndactyly

Pfeiffer Syndrome Type 2

Acrocephalosyndactylia Type V

Filatov'S Disease

Monocytic Angina

Mononucleosis

Pfeiffer'S Disease

Acsv

Acrocephalosyndactyly, Type 5

Craniofacial-Skeletal-Dermatologic Syndrome

Pfeiffer Syndrome Type 1

Classic Pfeiffer Syndrome

PS

Pfeiffer Syndrome Variant

Dysplasia, Craniofacial-Skeletal-Dermatologic

Pfeiffer

Kissing Disease

Infectious Adenitis

Pfeiffer Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12980 SLAMF6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SLAMF6 VGNC VGNC:46207
Macaca mulatta SLAMF6 VGNC VGNC:77546
Bos taurus SLAMF6 VGNC VGNC:34654
Mus musculus SLAMF6 MGD MGI:1353620
Felis catus SLAMF6 VGNC VGNC:107939
Rattus norvegicus SLAMF6 RGD RGD:1561848
Macaca fascicularis SLAMF6 NCBI NCBI:102137667
Others SLAMF6 NCBI
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