SLAMF6 蛋白, Human (198a.a, HEK293, His)

SLAMF6 protein is an autoligand receptor in the SLAM family, which is critical for the activation and differentiation of immune cells and coordinates innate and adaptive immune responses. SLAMF6 is regulated by cytoplasmic adapters such as SH2D1A/SAP and/or SH2D1B/EAT-2, and can trigger the cytolytic activity of NK cells, including VAV1 phosphorylation and SH2D1B dependence. SLAMF6 Protein, Human (198a.a, HEK293, His) is the recombinant human-derived SLAMF6 protein, expressed by HEK293 , with C-6*His labeled tag.

SLAMF6 是信号淋巴细胞激活分子 (SLAM) 家族中的一种自配体受体，在调节多种免疫细胞的激活和分化中发挥着至关重要的作用，有助于先天性和适应性免疫反应的复杂调节和协调。SLAMF6 的活性通过小细胞质接头蛋白（例如 SH2D1A/SAP 和/或 SH2D1B/EAT-2）的存在或不存在来精细控制。值得注意的是，SLAMF6 特别在表达高表面密度天然细胞毒性受体的自然杀伤 (NK) 细胞中触发细胞溶解活性，并在 NK 细胞中参与正信号传导，涉及 VAV1 的磷酸化和对 SH2D1B 而不是 SH2D1A 的依赖。SLAMF6 与 SLAMF1 一起控制胸腺细胞自然杀伤 T (NKT) 细胞谱系的转变和分化。此外，SLAMF6 促进 T 细胞分化为 Th17 表型，导致 IL-17 分泌增加，并与 SLAMF1 和 CD84/SLAMF5 协同作用，作为体液免疫反应的潜在负调节因子。此外，在缺乏SH2D1A/SAP的情况下，SLAMF6可以向CD4(+) T细胞和NKT细胞传递负信号，负向调节生发中心的形成，并可能有助于生发中心的B细胞耐受，同时防止自身免疫。SLAMF6 以同二聚体形式存在，并与 PTN6 和 PTN11 以及 SH2D1A/SAP 和 SH2D1B/EAT2 相互作用，两种接头蛋白都能够在 ITSM 2 介导下与相同的 SLAMF6 分子结合。

Human

HEK293

C-6*His

Q96DU3-1 (L28-K225)

114836  [NCBI]

LMVNGILGESVTLPLEFPAGEKVNFITWLFNETSLAFIVPHETKSPEIHVTNPKQGKRLNFTQSYSLQLSNLKMEDTGSYRAQISTKTSAKLSSYTLRILRQLRNIQVTNHSQLFQNMTCELHLTCSVEDADDNVSFRWEALGNTLSSQPNLTVSWDPRISSEQDYTCIAENAVSNLSFSVSAQKLCEDVKIQYTDTK

30-50 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.