GZMK - granzyme K Gene

中文名称：颗粒酶 K

种属: Homo sapiens

同用名: TRYP2

关于 GZMK

功能概要

该基因产物是来自细胞毒性淋巴细胞的细胞质颗粒的一组相关丝氨酸蛋白酶的成员。溶细胞性 T 淋巴细胞 (CTL) 和自然杀伤 (NK) 细胞具有识别、结合和裂解特定靶细胞的非凡能力。人们认为它们通过裂解表面带有“非自身”抗原的细胞来保护宿主，这些抗原通常是细胞内病原体感染产生的肽或蛋白质。此处描述的蛋白质缺乏其他颗粒酶中存在的 N-糖基化的共有序列。[RefSeq 提供，2008 年 7 月]

This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually Peptides or proteins resulting from Infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in Other granzymes. [provided by RefSeq, Jul 2008]