DDX19B - DEAD-box helicase 19B Gene

中文名称：死盒解旋酶 19B

种属: Homo sapiens

同用名: DBP5; RNAh; DDX19

关于 DDX19B

功能概要

以保守基序 Asp-Glu-Ala-Asp (DEAD) 为特征的 DEAD 盒蛋白是推定的 RNA 解旋酶。它们涉及许多涉及 RNA 二级结构改变的细胞过程，例如翻译起始、核和线粒体剪接以及核糖体和剪接体组装。根据它们的分布模式，该家族的一些成员被认为参与了胚胎发生、精子发生以及细胞生长和分裂。该基因编码 DEAD box 蛋白，该蛋白具有 RNA 依赖性 ATP 酶和 ATP 依赖性 RNA 解旋活性。这种蛋白质被募集到核孔复合体的细胞质原纤维中，参与 mRNA 从细胞核的输出。已为该基因发现编码不同亚型的多个可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]