1. Gene
  2. MFSD10 - major facilitator superfamily domain containing 10 Gene

MFSD10 - major facilitator superfamily domain containing 10 Gene

中文名称:含主要促进超家族结构域 10

种属: Homo sapiens

同用名: TETRAN; TETTRAN

基因 ID: 10227 | 基因类型: protein coding

关于 MFSD10

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:2,930,567-2,934,825 (from NCBI)

This gene has 11 transcripts (splice variants), 571 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 36.8), spleen (RPKM 13.5) and 24 other tissues.

功能概要

该基因编码转运蛋白主要促进子超家族的成员。编码的蛋白质可能在有机阴离子的流出中起作用,包括非甾体抗炎药吲哚美辛和双氯芬酸。已经描述了选择性剪接的转录物变体。[RefSeq 提供,2009 年 3 月]

This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein likely functions in efflux of organic anions, including the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

MFSD10 基因产物(4)

mRNA Protein Name
NM_001120.5 NP_001111.3 major facilitator superfamily domain-containing protein 10 isoform a
NM_001146069.2 NP_001139541.1 major facilitator superfamily domain-containing protein 10 isoform a
NM_001363679.2 NP_001350608.1 major facilitator superfamily domain-containing protein 10 isoform b
NM_001410703.1 NP_001397632.1 major facilitator superfamily domain-containing protein 10 isoform c
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables organic anion transmembrane transporter activity IDA
IDA: 通过直接分析推断
18638446 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within sodium-independent organic anion transport IDA
IDA: 通过直接分析推断
18638446 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic vesicle membrane IDA
IDA: 通过直接分析推断
18638446 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MFSD10 蛋白结构

MFS_1

MFS_1: Major Facilitator Superfamily (28 - 412)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 455 a.a.
蛋白主名 其他名称

major facilitator superfamily domain-containing protein 10

tetracycline transporter-like protein

MFSD10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MFSD10 Q14728 TGFBR2 Homo sapiens P37173
Y2H Pooling
32814053
Intra MFSD10 Q14728 TGFBR2 Homo sapiens P37173
Validated Y2H
32814053
Intra MFSD10 Q14728 TGFBR2 Homo sapiens P37173
Y2H Array
32814053
Intra MFSD10 Q14728 PECAM1 Homo sapiens P16284
Y2H Pooling
32814053
Intra MFSD10 Q14728 PECAM1 Homo sapiens P16284
Validated Y2H
32814053
Intra MFSD10 Q14728 PECAM1 Homo sapiens P16284
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Mahvash Disease

Gcgr-Related Hyperglucagonemia

MVAH

Alpha-Cell Hyperplasia With Glucagonemia

Nesidioblastosis, Alpha Cell Hyperplasia, Microglucagonoma, And Nonfunctioning Islet Cell Tumor

Nesidioblastosis Alpha Cell Hyperplasia Microglucagonoma And Nonfunctioning Islet Cell Tumor

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus MFSD10 VGNC VGNC:63475
Canis familiaris MFSD10 VGNC VGNC:43196
Rattus norvegicus MFSD10 RGD RGD:1311900
Bos taurus MFSD10 VGNC VGNC:31432
Macaca mulatta MFSD10 VGNC VGNC:100247
Mus musculus MFSD10 MGD MGI:1915544