PEG10 - paternally expressed 10 Gene

中文名称：父系表达 10

种属: Homo sapiens

同用名: EDR; HB-1; Mar2; RTL2; MEF3L; Mart2; RGAG3; SIRH1

基因 ID: 23089 | 基因类型: protein coding

关于 PEG10

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:94,656,325-94,669,695 (from NCBI)

This gene has 9 transcripts (splice variants), 274 orthologues and 10 paralogues. Biased expression in placenta (RPKM 304.5), adrenal (RPKM 114.1) and 3 other tissues.

功能概要

这是一种父系表达的印记基因，被认为源自逆转录转座子的 Ty3/Gypsy 家族。它包含两个重叠的开放阅读框 RF1 和 RF2，并表达两种蛋白质：一种来自 RF1 的较短的 gag 样蛋白质 (具有 CCHC 型锌指结构域) ；和更长的 gag/pol 样融合蛋白 (带有额外的天冬氨酸蛋白酶基序) 来自 RF1/RF2，通过 -1 翻译移码 (-1 FS) 。虽然在原核生物和真核生物的 RNA 病毒和转座子中都观察到 -1 FS，但该基因代表了真核细胞基因中 -1 FS 的第一个例子。该基因在哺乳动物物种中高度保守，并保留了 -1 FS 所需的七核苷酸 (GGGAAAC) 和假结元件。它在成人和胚胎组织 (最显着的是胎盘) 中表达，据报道在细胞增殖、分化和凋亡中起作用。该基因的过度表达与多种恶性肿瘤有关，例如肝细胞癌和 B 细胞淋巴细胞白血病。缺乏该基因的基因敲除小鼠表现出早期胚胎致死性并伴有胎盘缺陷，表明该基因在胚胎发育中的重要性。已经报道了该基因由可变剪接的转录本变体产生的其他同种型，以及上游非 AUG (CUG) 起始密码子的使用。[RefSeq 提供，2014 年 10 月]

This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic Protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and Apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene. [provided by RefSeq, Oct 2014]

PEG10 基因产物(6)

mRNA	Protein	Name
NM_001040152.2	NP_001035242.1	retrotransposon-derived protein PEG10 isoform 2
NM_001172437.2	NP_001165908.1	retrotransposon-derived protein PEG10 isoform 3
NM_001172438.3	NP_001165909.1	retrotransposon-derived protein PEG10 isoform 4
NM_001184961.1	NP_001171890.1	retrotransposon-derived protein PEG10 isoform 5
NM_001184962.2	NP_001171891.1	retrotransposon-derived protein PEG10 isoform 6
NM_015068.3	NP_055883.2	retrotransposon-derived protein PEG10 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15611116	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: 通过直接分析推断	15611116	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	15611116	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PEG10 蛋白结构

Retrotrans_gag

0
100
200
300
325 a.a.

蛋白主名

其他名称

retrotransposon-derived protein PEG10

MEF3 like 1

PEG10 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	PEG10	Q86TG7	RTL8C	Homo sapiens	A6ZKI3	Anti Tag CoIP	33961781
Intra	PEG10	Q86TG7	RTL8C	Homo sapiens	A6ZKI3	Validated Y2H	25416956
Intra	PEG10	Q86TG7	RTL8B	Homo sapiens	Q17RB0	Anti Tag CoIP	33961781
Intra	PEG10	Q86TG7	RTL8B	Homo sapiens	Q17RB0	Y2H Prey Pooling	25416956
Intra	PEG10	Q86TG7	LNX2	Homo sapiens	Q8N448	Y2H Array	29892012
Intra	PEG10	Q86TG7	LNX2	Homo sapiens	Q8N448	Y2H Array	31515488
Intra	PEG10	Q86TG7	CALCOCO2	Homo sapiens	Q13137	Y2H Array	31515488
Intra	PEG10	Q86TG7	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	25416956
Intra	PEG10	Q86TG7	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	25416956
Intra	PEG10	Q86TG7	CALCOCO2	Homo sapiens	Q13137	Y2H Array	25416956
Intra	PEG10	Q86TG7	LDOC1	Homo sapiens	O95751	Y2H Array	31515488
Intra	PEG10	Q86TG7	LDOC1	Homo sapiens	O95751	Anti Tag CoIP	33961781
Intra	PEG10	Q86TG7	LDOC1	Homo sapiens	O95751	Y2H Prey Pooling	25416956
Intra	PEG10	Q86TG7	SIAH1	Homo sapiens	Q8IUQ4	Y2H Prey Pooling	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Diffuse Large B-Cell Lymphoma

Dlbcl	Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Large B-Cell Diffuse Lymphoma	Lymphoma, Large B-Cell, Diffuse
Dlbcl - [Diffuse Large B-Cell Lymphoma]	Diffuse Large Beta Cell Lymphoma

Esophageal Cancer

Esophageal Carcinoma	Carcinoma Of Esophagus
Esophageal Squamous Cell Carcinoma, Somatic	Esophageal Carcinoma, Somatic
Esophagus Cancer	Gastric Cardia Adenocarcinoma
Esophageal Neoplasms	Esophageal Cancer, Somatic
Cancer Of Esophagus	Cancer Of Oesophagus
Carcinoma Of Oesophagus	Ca Lower Third Oesophagus
Ca Middle Third Oesophagus	Malignant Neoplasm Of Distal Third Of Esophagus
Malignant Neoplasm Of Lower Third Of Oesophagus	Malignant Neoplasm Of Middle Third Of Oesophagus
Malignant Neoplasm Of Proximal Third Of Esophagus	Malignant Neoplasm Of Upper Third Esophagus
Malignant Tumor Of Abdominal Esophagus	Malignant Tumor Of Distal Third Of Esophagus
Malignant Tumor Of Proximal Third Of Esophagus	Malignant Tumor Of The Middle Third Of The Esophagus
ESCR	Aerodigestive Tract Cancer
Escc	Esophageal Squamous Cell Carcinoma
Cancer, Esophageal	Malignant Neoplasm Of Esophagus
Squamous Cell Carcinoma Of Esophagus	Malignant Neoplasm Of Middle Third Of Esophagus

B-Lymphoblastic Leukemia/Lymphoma

B Lymphoblastic Leukemia/Lymphoma	B-All
Precursor B Lymphoblastic Lymphoma/Leukemia	C-All
Lymphoblastic Lymphoma, Nos	Common Precursor B All
Lymphoblastic B-Cell Lymphoma	Pro-B All
B-Precursor Lymphoma	Lbl - [Lymphoblastic Lymphoma]

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Angelman Syndrome

AS	Happy Puppet Syndrome
Happy Puppet Syndrome, Formerly	Puppetlike Syndrome

Gallbladder Adenocarcinoma

Adenocarcinoma Of The Gallbladder

Carcinoma Of The Gallbladder

Silver-Russell Syndrome 1

Silver-Russell Syndrome	Russell-Silver Syndrome
Silver-Russell Dwarfism	Rss
SRS1	Srs
Silver Russell Dwarfism	Russell Silver Syndrome
Silver Russell Syndrome

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Spastic Paraplegia 17, Autosomal Dominant

Silver Syndrome	SPG17
Silver Spastic Paraplegia Syndrome	Spastic Paraplegia With Amyotrophy Of Hands And Feet
Hereditary Spastic Paraplegia 17	Autosomal Dominant Spastic Paraplegia Type 17
Spastic Paraplegia 17	Spastic Paraplegia-Amyotrophy Of Hands And Feet
Autosomal Dominant Spastic Paraplegia 17	Dhmn5b
Distal Hereditary Motor Neuropathy Type 5b	Paraplegia, Spastic, Autosomal Dominant, Type 17
Russell-Silver Syndrome	Neuronopathy, Distal Hereditary Motor, Type Vb

Transient Neonatal Diabetes Mellitus

Diabetes Mellitus, Transient Neonatal	Tndm
Chromosome 6-Associated Transient Diabetes Mellitus	Dmtn
Diabetes Mellitus, 6q24-Related Transient Neonatal	Tndm1
Neonatal Diabetes Mellitus, Transient	Tndm -[Transient Neonatal Diabetes Mellitus]

Osteogenesis Imperfecta, Type Iii

Osteogenesis Imperfecta Type Iii	OI3
Oi, Type Iii	Osteogenesis Imperfecta Type 3
Oi Type Iii	Oi Type 3
Progressive Deforming Osteogenesis Imperfecta	Severe Osteogenesis Imperfecta
Osteogenesis Imperfecta, Progressively Deforming, With Normal Sclerae	Progressively Deforming Osteogenesis Imperfecta With Normal Sclera
Osteogenesis Imperfecta, Progressively Deforming With Normal Sclerae	Progressively Deforming Oi
Osteogenesis Imperfecta 3	Oi-Iii
Progressively Deforming Osteogenesis Imperfecta With Normal Sclerae

Beckwith-Wiedemann Syndrome

Wiedemann-Beckwith Syndrome	BWS
Exomphalos-Macroglossia-Gigantism Syndrome	Emg Syndrome
Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation	Emg Abnormality
Wbs	Exomphalos Macroglossia Gigantism Syndrome
Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation	Macroglossia Exomphalos Gigantism

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-140217	Azido-PEG10-amine		≥97.0%	否
HY-141232	Decaethylene glycol		99.13%	否
HY-W040270	Amino-PEG10-amine		≥97.0%	否
HY-130824	Bis-PEG10-NHS ester		≥95.0%	否
HY-140759	Azido-PEG10-NHS ester		≥98.0%	否
HY-126509	Mal-amido-PEG10-C2-NHS ester		95.23%	否
HY-133231	Bis-PEG10-acid		≥98.0%	否
HY-138726	Mal-PEG10-NHS ester		/	否
HY-141218	m-PEG10-alcohol		≥97.0%	否
HY-133304	HO-PEG10-CH2COOH		≥98.0%	否
HY-139018	TLR7/8 agonist 4 hydroxy-PEG10-acid		/	否
HY-139018A	TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride		/	否
HY-120761	Amino-PEG10-OH		/	否
HY-126508	Mal-amido-PEG5-C2-NHS ester		/	否
HY-130424	m-PEG10-azide		/	否
HY-132057	Bis-PEG10-t-butyl ester		/	否
HY-132065	Decaethylene glycol dodecyl ether		99.91%	否
HY-132076	Azido-PEG10-azide		/	否
HY-132081	Benzyl-PEG10-t-butyl ester		/	否
HY-132098	Bis-propargyl-PEG10		/	否
HY-132118	Bromo-PEG10-t-butyl ester		/	否
HY-133230	Propargyl-PEG10-amine		/	否
HY-133270	m-PEG10-SH		/	否
HY-133307	Hydroxy-PEG10-acid		99.59%	否
HY-134718	Glycocholic acid-PEG10-iodoacetamide		/	否
HY-134747	THP-PEG10-THP		/	否
HY-135930	Boc-NH-PEG10-CH2CH2NH2		/	否
HY-138316	THP-PEG10-C2-Boc		/	否
HY-138341	Benzyl-PEG10-THP		/	否
HY-138344	MS-PEG10-THP		/	否
HY-138347	THP-PEG10-Boc		/	否
HY-138350	Azido-PEG10-CH2CO2-NHS		/	否
HY-138390	NH2-PEG10-C2-dimethylamino		/	否
HY-138413	THP-PEG10-OH		/	否
HY-138416	Azido-PEG10-CH2COOH		/	否
HY-138460	Propargyl-PEG10-alcohol		/	否
HY-138713	Benzyl-PEG10-Ots		/	否
HY-138721	Fmoc-PEG10-NHS ester		/	否
HY-138722	Mal-PEG10-Boc		/	否
HY-138723	Mal-PEG10-acid		/	否
HY-138739	Azido-PEG10-propargyl		/	否
HY-140020	Propargyl-PEG10-acid		≥98.0%	否
HY-140029	Propargyl-PEG10-Boc		/	否
HY-140226	m-PEG10-amine		/	否
HY-140304	DBCO-PEG10-DBCO		/	否
HY-140360	m-PEG10-Tos		/	否
HY-140455	Azido-PEG10-acid		/	否
HY-140500	m-PEG10-acid		/	否
HY-140781	Azido-PEG10-Boc		/	否
HY-140801	Azido-PEG10-alcohol		/	否
HY-140861	Trityl-PEG10-azide		/	否
HY-140973	Mal-amido-PEG10-acid		/	否
HY-141104	m-PEG10-NHS ester		/	否
HY-141130	LG-PEG10-click-DBCO-Oleic		/	否
HY-141399	m-PEG10-T-Butyl ester		/	否
HY-143827	Biotin-PEG10-amine		/	否
HY-143828	t-Boc-N-amido-PEG10-Br		/	否
HY-143836	Acid-PEG10-t-butyl ester		/	否
HY-143855	Biotin-PEG10-NHS ester		/	否
HY-144076	t-Boc-amido-PEG10-acid		/	否
HY-RS10318	PEG10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-W019939	Hydroxy-PEG10-Boc		/	否
HY-W096081	Benzyl-PEG10-alcohol		/	否
HY-W190857	N-Boc-PEG10-alcohol		/	否
HY-133335	Amino-PEG10-CH2-Boc		/	否
HY-164654	DOTA-PEG10-azide		/	否
HY-P10392AF	fStAx-35R TFA	Inhibitor	97.35%	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	PEG10	VGNC	VGNC:50004
Canis familiaris	PEG10	VGNC	VGNC:49685
Mus musculus	PEG10	MGD	MGI:2157785
Felis catus	PEG10	VGNC	VGNC:102657
Rattus norvegicus	PEG10	RGD	RGD:1595574

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PEG10 - paternally expressed 10 Gene

关于 PEG10

功能概要

PEG10 基因产物(6)

PEG10 蛋白结构

PEG10 蛋白互作信息

关联疾病

直系同源

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PEG10 - paternally expressed 10 Gene

关于 PEG10

功能概要

PEG10 基因产物(6)

PEG10 蛋白结构

PEG10 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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C

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