2. Gene
  3. IP6K2 - inositol hexakisphosphate kinase 2 Gene

IP6K2 - inositol hexakisphosphate kinase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：肌醇六磷酸激酶 2

种属: Homo sapiens

同用名: PIUS; IHPK2; InsP6K2

基因 ID: 51447 | 基因类型: protein coding

关于 IP6K2

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,688,003-48,717,221 (from NCBI)

This gene has 28 transcripts (splice variants), 267 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 16.6), skin (RPKM 16.3) and 25 other tissues.

功能概要

该基因编码属于肌醇磷酸激酶 (IPK) 家族的蛋白质。这种蛋白质可能负责将肌醇六磷酸 (InsP6) 转化为二磷酸肌醇五磷酸 (InsP7/PP-InsP5) 。它还可能将 1,3,4,5,6-五磷酸 (InsP5) 转化为 PP-InsP4，并影响某些卵巢癌中干扰素-β 的生长抑制和细胞凋亡活性。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

IP6K2 基因产物(8)

mRNA Protein Name
NM_001005909.3 NP_001005909.1 inositol hexakisphosphate kinase 2 isoform a
NM_001005910.3 NP_001005910.1 inositol hexakisphosphate kinase 2 isoform b
NM_001005911.3 NP_001005911.1 inositol hexakisphosphate kinase 2 isoform b
NM_001146178.3 NP_001139650.1 inositol hexakisphosphate kinase 2 isoform c
NM_001146179.3 NP_001139651.1 inositol hexakisphosphate kinase 2 isoform c
NM_001190316.2 NP_001177245.1 inositol hexakisphosphate kinase 2 isoform d
NM_001190317.2 NP_001177246.1 inositol hexakisphosphate kinase 2 isoform e
NM_016291.4 NP_057375.2 inositol hexakisphosphate kinase 2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables flavonoid binding IDA
IDA: 通过直接分析推断
30624931 GOA
enables inositol hexakisphosphate 5-kinase activity IDA
IDA: 通过直接分析推断
30624931 GOA
enables inositol hexakisphosphate kinase activity IDA
IDA: 通过直接分析推断
10574768 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18195352 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to flavonoid IMP
IMP: 通过突变表型推断
30624931 GOA
involved in inositol phosphate metabolic process IDA
IDA: 通过直接分析推断
30624931 GOA
involved in negative regulation of cell growth IMP
IMP: 通过突变表型推断
11337497 GOA
involved in phosphatidylinositol phosphate biosynthetic process IDA
IDA: 通过直接分析推断
10574768 GOA
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
11337497 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
11502751 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IP6K2 蛋白结构

IPK

IPK: Inositol polyphosphate kinase (203 - 417)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 426 a.a.
蛋白主名 其他名称

inositol hexakisphosphate kinase 2

ATP:1D-myo-inositol-hexakisphosphate phosphotransferase

IP6K2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra IP6K2 Q9UHH9 PGK2 Homo sapiens P07205
Anti Tag CoIP
33961781
Intra IP6K2 Q9UHH9 PGK2 Homo sapiens P07205
Anti Tag CoIP
28514442
Intra IP6K2 Q9UHH9 LNX2 Homo sapiens Q8N448
Y2H Array
29892012
Intra IP6K2 Q9UHH9 LNX2 Homo sapiens Q8N448
Y2H Array
31515488
Intra IP6K2 Q9UHH9 ZBTB2 Homo sapiens Q8N680
Y2H Prey Pooling
32296183
Intra IP6K2 Q9UHH9 ZBTB2 Homo sapiens Q8N680
Y2H Array
32296183
Intra IP6K2 Q9UHH9 TP53 Homo sapiens P04637
Pull Down
21078964
Intra IP6K2 Q9UHH9 TP53 Homo sapiens P04637
Anti Bait CoIP
21078964
Intra IP6K2 Q9UHH9 RBPMS Homo sapiens Q93062
Y2H Array
25416956
Intra IP6K2 Q9UHH9 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Intra IP6K2 Q9UHH9 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-150607 UNC7467 98.07% 否
HY-153530 LI-2242 98.95% 否
HY-122706 TBK1/IKKε-IN-3 / 否
HY-RS06862 IP6K2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-161032 IP6K2-IN-1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus IP6K2 VGNC VGNC:62952
Mus musculus IP6K2 MGD MGI:1923750
Macaca mulatta IP6K2 VGNC VGNC:73612
Rattus norvegicus IP6K2 RGD RGD:620529
Canis familiaris IP6K2 VGNC VGNC:42062
Bos taurus IP6K2 VGNC VGNC:30238
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