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UNC7467 是一种有效的 IP6K抑制剂，IP6K2、IP6K1 和 IP6K6 的 IC50 值分别为 4.9、8.9 和1320 nM。UNC7467 可降低肌醇焦磷酸盐的水平。UNC7467 可用于肥胖研究。

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UNC7467 Chemical Structure

UNC7467 Chemical Structure

CAS No. : 2922283-43-8

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥5459
In-stock
100 mg ￥4963
In-stock
500 mg 现货 询价
1 g   询价  
5 g   询价  

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Customer Review

UNC7467 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates. UNC7467 can be used for obesity research[1].

IC50 & Target

IC50: 4.9 nM (IP6K2), 8.9 nM (IP6K1), 1320 nM (IP6K3)[1].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 EC50
0.24 μM
Compound: 20; UNC7467
Reduction in InsP8-dependent [33P]-inorganic phosphate efflux in human HCT-116 cells measured after 18 hrs by HPLC analysis
Reduction in InsP8-dependent [33P]-inorganic phosphate efflux in human HCT-116 cells measured after 18 hrs by HPLC analysis
[PMID: 35467861]
HCT-116 EC50
1 μM
Compound: 20; UNC7467
Reduction in InsP8-dependent [33P]-inorganic phosphate efflux in human HCT-116 cells measured after 3 hrs by HPLC analysis
Reduction in InsP8-dependent [33P]-inorganic phosphate efflux in human HCT-116 cells measured after 3 hrs by HPLC analysis
[PMID: 35467861]
体外研究
(In Vitro)

UNC7467 (2.5 μM; 3 hours; HCT116 cells) reduces levels of inositol pyrophosphates. UNC7467 reduces 5-InsP7 levels by 81% and 5-InsP8 levels by 63%[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

UNC7467 相关抗体:
体内研究
(In Vivo)

UNC7467 (5 mg/kg; i.p.; daily, for 4 weeks; diet-induced obesity mice) ameliorated diet induced obesity, insulin resistance, and hepatic steatosis[1].
UNC7467 (1-5 mg/kg; i.v. and i.p.; diet-induced obesity mice) exhibits low clearance (13.7 (mL/min)/kg) and large AUClast (6054 h•ng/mL for intra venous (i.v.) and 2527 h•ng/mL for intraperitoneal (i.p.)) in mice at 5 mg/kg dose[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diet-induced obesity (DIO) mice[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; daily, for 4 weeks
Result: Improved glycemic profiles, ameliorated hepatic steatosis, and reduced weight gain without altering food intake.
Animal Model: Diet-induced obesity (DIO) mice[1]
Dosage: 5 mg/kg (Pharmacokinetic Analysis)
Administration: Intravenous injection and intraperitoneal injection
Result: 1.19
route iv ip
Dose (mg/kg) 5 5
AUClast (h*ng/mL) 6054 2527
CL (mL/min/kg) 13.7
分子量

315.32

Formula

C20H13NO3
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 14.29 mg/mL (45.32 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1714 mL 15.8569 mL 31.7138 mL
5 mM 0.6343 mL 3.1714 mL 6.3428 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

UNC7467 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1714 mL 15.8569 mL 31.7138 mL 79.2845 mL
5 mM 0.6343 mL 3.1714 mL 6.3428 mL 15.8569 mL
10 mM 0.3171 mL 1.5857 mL 3.1714 mL 7.9285 mL
15 mM 0.2114 mL 1.0571 mL 2.1143 mL 5.2856 mL
20 mM 0.1586 mL 0.7928 mL 1.5857 mL 3.9642 mL
25 mM 0.1269 mL 0.6343 mL 1.2686 mL 3.1714 mL
30 mM 0.1057 mL 0.5286 mL 1.0571 mL 2.6428 mL
40 mM 0.0793 mL 0.3964 mL 0.7928 mL 1.9821 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UNC74672922283-43-8UNC 7467UNC-7467OthersIP6Kinositol pyrophosphatesobesityInhibitorinhibitorinhibit

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