PTPN6 - protein tyrosine phosphatase non-receptor type 6 Gene

中文名称：蛋白酪氨酸磷酸酶非受体 6 型

种属: Homo sapiens

同用名: HCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1

基因 ID: 5777 | 基因类型: protein coding

关于 PTPN6

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,946,577-6,961,316 (from NCBI)

This gene has 23 transcripts (splice variants), 198 orthologues, 35 paralogues and is associated with 61 phenotypes. Broad expression in spleen (RPKM 76.2), lymph node (RPKM 74.9) and 19 other tissues.

功能概要

该基因编码的蛋白质是蛋白酪氨酸磷酸酶 (PTP) 家族的成员。已知 PTP 是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。该 PTP 的 N 端部分包含两个串联 Src 同系物 (SH2) 结构域，它们充当蛋白质磷酸-酪氨酸结合结构域，并介导该 PTP 与其底物的相互作用。该 PTP 主要在造血细胞中表达，在造血细胞中作为多种信号通路的重要调节剂发挥作用。已证明该 PTP 与参与造血细胞信号转导的多种磷酸化蛋白相互作用并使其去磷酸化。已经报道了该基因的多个选择性剪接变体，它们编码不同的同种型。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

PTPN6 基因产物(3)

mRNA	Protein	Name
NM_002831.6	NP_002822.2	tyrosine-protein phosphatase non-receptor type 6 isoform 1
NM_080548.5	NP_536858.1	tyrosine-protein phosphatase non-receptor type 6 isoform 2
NM_080549.4	NP_536859.1	tyrosine-protein phosphatase non-receptor type 6 isoform 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables phosphorylation-dependent protein binding	IPI IPI: 通过物理相互作用推断	11162587	GOA
enables phosphotyrosine residue binding	IPI IPI: 通过物理相互作用推断	11986327	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	7228577	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	11266449	GOA
enables protein tyrosine phosphatase activity	IDA IDA: 通过直接分析推断	17562706	GOA
enables protein tyrosine phosphatase activity	IMP IMP: 通过突变表型推断	10206955	GOA
enables transmembrane receptor protein tyrosine phosphatase activity	IDA IDA: 通过直接分析推断	11266449	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in CD27 signaling pathway	IDA IDA: 通过直接分析推断	38354704	GOA
involved in T cell activation	IDA IDA: 通过直接分析推断	38354704	GOA
involved in cell differentiation	IDA IDA: 通过直接分析推断	11266449	GOA
involved in negative regulation of B cell receptor signaling pathway	IDA IDA: 通过直接分析推断	35941532	GOA
involved in negative regulation of angiogenesis	IDA IDA: 通过直接分析推断	23896411	GOA
involved in negative regulation of inflammatory response to wounding	IDA IDA: 通过直接分析推断	27830702	GOA
involved in negative regulation of innate immune response	IDA IDA: 通过直接分析推断	34811497	GOA
involved in negative regulation of peptidyl-tyrosine phosphorylation	IMP IMP: 通过突变表型推断	19749791	GOA
involved in peptidyl-tyrosine dephosphorylation	IMP IMP: 通过突变表型推断	17562706	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: 通过直接分析推断	9285411	GOA
involved in positive regulation of cell population proliferation	IMP IMP: 通过突变表型推断	19749791	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: 通过突变表型推断	19838216	GOA
involved in protein dephosphorylation	IDA IDA: 通过直接分析推断	11266449	GOA
involved in regulation of ERK1 and ERK2 cascade	IDA IDA: 通过直接分析推断	11266449	GOA
involved in regulation of G1/S transition of mitotic cell cycle	IMP IMP: 通过突变表型推断	19838216	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in cytoplasm	IDA IDA: 通过直接分析推断	9065461	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	10940933	GOA
located in nucleus	IDA IDA: 通过直接分析推断	19838216	GOA
is active in plasma membrane	IDA IDA: 通过直接分析推断	23896411	GOA
part of protein-containing complex	IMP IMP: 通过突变表型推断	17562706	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PTPN6 蛋白结构

SH2

Y_phosphatase

0
100
200
300
400
500
595 a.a.

蛋白主名

其他名称

tyrosine-protein phosphatase non-receptor type 6

hematopoietic cell phosphatase

PTPN6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PTPN6	P29350	KDR	Homo sapiens	P35968	Ub Reconstruction	28065597
种属内	PTPN6	P29350	LCK	Homo sapiens	P06239	Protein Kinase Assay	8114715
种属内	PTPN6	P29350	NFAT5	Homo sapiens	O94916-1	Anti Bait CoIP	20351292
种属内	PTPN6	P29350	NFAT5	Homo sapiens	O94916-1	Anti Tag CoIP	20351292
种属内	PTPN6	P29350	PTPN12	Homo sapiens	Q05209	Anti Tag CoIP	31980649
种属内	PTPN6	P29350	PTPN12	Homo sapiens	Q05209	Anti Tag CoIP	33961781
种属内	PTPN6	P29350	LILRB4	Homo sapiens	Q8NHJ6	Anti Bait CoIP	18802077
种属内	PTPN6	P29350	LILRB1	Homo sapiens	Q8NHL6	Anti Bait CoIP	18802077
种属内	PTPN6	P29350	LILRB2	Homo sapiens	Q8N423	Anti Bait CoIP	18802077
种属内	PTPN6	P29350	LILRB3	Homo sapiens	O75022	Anti Bait CoIP	18802077
种属内	PTPN6	P29350	THEMIS	Homo sapiens	Q8N1K5	Anti Bait CoIP	25535246
种属内	PTPN6	P29350	CD33	Homo sapiens	P20138	CoIP	10206955
种属内	PTPN6	P29350	CD33	Homo sapiens	P20138	CoIP	10556798
种属内	PTPN6	P29350	CD33	Homo sapiens	P20138	Enzymatic Study	10556798
种属内	PTPN6	P29350	IGF1R	Homo sapiens	P08069	Ub Reconstruction	28065597
种属内	PTPN6	P29350	CD37	Homo sapiens	P11049	Anti Bait CoIP	22624718
种属内	PTPN6	P29350	EPOR	Homo sapiens	P19235	Affinity Chrom	7228577
种属内	PTPN6	P29350	EPOR	Homo sapiens	P19235	Pull Down	7228577
种属内	PTPN6	P29350	EPOR	Homo sapiens	P19235	Pull Down	7528577
种属间	PTPN6	P29350	tir	Escherichia coli O157:H7	Q7DB77	Anti Tag CoIP	23001144
种属内	PTPN6	P29350	PECAM1	Homo sapiens	P16284	Pull Down	9774457
种属内	PTPN6	P29350	PECAM1	Homo sapiens	P16284	SPR	9774457
种属内	PTPN6	P29350	FCGR2B	Homo sapiens	P31994	SELDI Chip	8577729
种属内	PTPN6	P29350	FCGR2B	Homo sapiens	P31994	Affinity Chrom	9148918
种属内	PTPN6	P29350	ROS1	Homo sapiens	P08922	Pull Down	11266449
种属内	PTPN6	P29350	ROS1	Homo sapiens	P08922	CoIP	11266449
种属内	PTPN6	P29350	FHL3	Homo sapiens	Q13643	Y2H Array	25416956
种属内	PTPN6	P29350	CASP8	Homo sapiens	Q14790	Anti Bait CoIP	18086677
种属内	PTPN6	P29350	CASP8	Homo sapiens	Q14790	Anti Tag CoIP	18086677
种属内	PTPN6	P29350	KIR2DL3	Homo sapiens	P43628	Pull Down	8691154
种属内	PTPN6	P29350	KIR2DL3	Homo sapiens	P43628	Pull Down	8648092
种属内	PTPN6	P29350	KIR2DL3	Homo sapiens	P43628	Affinity Chrom	9148918
种属内	PTPN6	P29350	KIR2DL1	Homo sapiens	P43626	CoIP	8691146
种属内	PTPN6	P29350	KIR2DL1	Homo sapiens	P43626	Pull Down	8691146
种属内	PTPN6	P29350	PILRA	Homo sapiens	Q9UKJ1	SPR	10660620
种属内	PTPN6	P29350	PILRA	Homo sapiens	Q9UKJ1	Y2H	10660620
种属内	PTPN6	P29350	LAIR1	Homo sapiens	Q6GTX8	Pull Down	10764762
种属内	PTPN6	P29350	LAIR1	Homo sapiens	Q6GTX8	Y2H	10660620
种属内	PTPN6	P29350	LAIR1	Homo sapiens	Q6GTX8	CoIP	10764762
种属间	PTPN6	P29350	tir	Escherichia coli O127:H6	B7UM99	Pull Down	23001144
种属间	PTPN6	P29350	Ppp1r9b	Rattus norvegicus	O35274	Anti Tag CoIP	25785436

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PTPN6 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71141	SHP-1 Protein, Human (His)	AAH02523.1 (K243-I541)	≥95%

PTPN6 抗体

目录号	产品名	应用	反应物种
HY-P81307	SHP1 Antibody (YA1044)	WB, IP	Human
HY-P81307A	SHP1 Antibody (YA1045)	WB, IHC-P	Human

关联疾病

疾病名称

别名

Polycythemia

Erythrocythemia	Polycythemia Vera
Polycythaemia Due To High Altitude

Polycythemia Vera

PV	Polycythemia Rubra Vera
Prv	Osler-Vaquez Disease
Chronic Erythremia	Polycythaemia Rubra Vera
Primary Polycythemia	Vaquez Disease
Polycythemia Vera, Somatic	Osler-Vaquez Syndrome
Proliferative Polycythaemia	Polycythemia Ruba Vera
Acquired Primary Erythrocytosis	Heilmeyer-Schoner Disease
Vaquez Osler Disease	Primary Polycythaemia

Neutrophilic Dermatosis, Acute Febrile

Sweet Syndrome	Acute Febrile Neutrophilic Dermatosis
Ss	AFND
Pyrin-Associated Autoinflammatory Disease	PAAND
Gomm-Button Disease	Sweet'S Syndrome
Gomm Button Disease	Sweets Syndrome
Acromelic Frontonasal Dysostosis	Sweet Disease

Severe Congenital Neutropenia

Congenital Neutropenia	Neutropenia, Severe Congenital
Congenital Agranulocytosis	Infantile Genetic Agranulocytosis
Kostmann Disease	Kostmann'S Agranulocytosis
Kostmann'S Syndrome	Severe Infantile Genetic Neutropenia

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Erythrocytosis, Familial, 1

ECYT1	Pfcp
Primary Familial And Congenital Polycythemia	Familial Erythrocytosis 1
Familial Erythrocytosis	Polycythemia, Primary Familial And Congenital
Autosomal Dominant Benign Erythrocytosis	Familial Erythrocytosis Type 1
Congenital Erythrocytosis Due To Erythropoietin Receptor Mutation	Congenital Polycythemia Due To Erythropoietin Receptor Mutation
Primary Congenital Erythrocytosis	Primary Familial Polycythemia
Erythrocytosis, Autosomal Dominant Benign	Erythrocytosis, Somatic
Autosomal Dominant Familial Erythrocytosis-1	Erythrocytosis Autosomal Dominant Benign
Familial Primary Polycythemia	Familial Erythrocytosis, 1
Erythrocytosis, Familial, Type 1

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-136657	SC-43		99.02%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11429	PTPN6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	PTPN6	VGNC	VGNC:69166
Rattus norvegicus	PTPN6	RGD	RGD:620660
Mus musculus	PTPN6	MGD	MGI:96055
Macaca mulatta	PTPN6	VGNC	VGNC:76607
Bos taurus	PTPN6	VGNC	VGNC:33541
Canis familiaris	PTPN6	VGNC	VGNC:45179
Others	PTPN6	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PTPN6 - protein tyrosine phosphatase non-receptor type 6 Gene

关于 PTPN6

功能概要

PTPN6 基因产物(3)

PTPN6 蛋白结构

PTPN6 蛋白互作信息

重组 PTPN6 蛋白

PTPN6 抗体

关联疾病

直系同源

热门区域

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PTPN6 - protein tyrosine phosphatase non-receptor type 6 Gene

关于 PTPN6

功能概要

PTPN6 基因产物(3)

PTPN6 蛋白结构

PTPN6 蛋白互作信息

重组 PTPN6 蛋白

PTPN6 抗体

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

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Q

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T

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