SHP-1 蛋白, Human (His)

SHP-1 Protein modulates signaling from tyrosine-phosphorylated cell surface receptors, including KIT and EGFR. It enhances the inhibition of mast cell activation via the Lilrb4a receptor. The SH2 regions interact with cellular components to regulate its phosphatase activity. In collaboration with MTUS1, it induces UBE2V2 expression upon angiotensin II stimulation. SHP-1 plays a crucial role in hematopoiesis. SHP-1 Protein, Human (His) is the recombinant human-derived SHP-1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of SHP-1 Protein, Human (His) is 299 a.a., with molecular weight of ~33.0 kDa.

SHP-1 蛋白是酪氨酸磷酸化细胞表面受体（包括 KIT 和 EGF 受体/EGFR）启动的信号通路的关键调节剂。此外，它还能增强对 Lilrb4a 受体介导的肥大细胞激活的抑制作用。SHP-1 的 SH2 区域可能与其他细胞成分结合，影响其针对相互作用底物的磷酸酶活性。值得注意的是，SHP-1 与 MTUS1 协同作用，诱导 UBE2V2 表达以响应血管紧张素 II 刺激。除了这些调节功能之外，SHP-1 在造血过程中发挥着关键作用，进一步强调了它在细胞过程和信号事件的复杂网络中的重要性。

Human

E. coli

C-6*His

AAH02523.1 (K243-I541)

5777  [NCBI]

KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNI

Approximately 33.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 25 mM Tris-HCl, 500 mM NaCl, 2 mM 2-Mercaptoethanol, 1 mM EDTA, 1 mM DTT, 20% Glycerol, pH 7.5.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.