2. Gene
  3. THEMIS - thymocyte selection associated Gene

THEMIS - thymocyte selection associated Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胸腺细胞选择相关

种属: Homo sapiens

同用名: GASP; SPOT; TSEPA; C6orf190; C6orf207

基因 ID: 387357 | 基因类型: protein coding

关于 THEMIS

Cytogenetic location: 6q22.33 Genomic coordinates (GRCh38): 6:127,696,628-127,918,595 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 167 orthologues and 1 paralogue. Biased expression in lymph node (RPKM 2.2), appendix (RPKM 1.1) and 12 other tissues.

功能概要

该基因编码的蛋白质在胸腺细胞发育晚期的阳性和阴性 T 细胞选择中起调节作用。该蛋白质通过 T 细胞抗原受体信号传导发挥作用，是 T 细胞正确谱系定型和成熟所必需的。可变剪接导致多个转录本变体。[RefSeq 提供，2009 年 9 月]

This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

THEMIS 基因产物(7)

mRNA Protein Name
NM_001010923.3 NP_001010923.1 protein THEMIS isoform 2
NM_001164685.2 NP_001158157.1 protein THEMIS isoform 1
NM_001164687.2 NP_001158159.1 protein THEMIS isoform 3
NM_001318531.1 NP_001305460.1 protein THEMIS isoform 4
NM_001394520.1 NP_001381449.1 protein THEMIS isoform 5
NM_001394521.1 NP_001381450.1 protein THEMIS isoform 6
NM_001394522.1 NP_001381451.1 protein THEMIS isoform 4
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21189249 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

THEMIS 蛋白结构

CABIT

CABIT: Cell-cycle sustaining, positive selection, (17 - 270)

CABIT

CABIT: Cell-cycle sustaining, positive selection, (281 - 533)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 641 a.a.
蛋白主名 其他名称

protein THEMIS

GRB2-associated protein

THEMIS 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
THEMIS Q8N1K5 GRB2 Homo sapiens P62993
Anti Tag CoIP
28046066
种属内
THEMIS Q8N1K5 GRB2 Homo sapiens P62993
Anti Bait CoIP
21189249
种属内
THEMIS Q8N1K5 GRB2 Homo sapiens P62993
Anti Tag CoIP
33961781
种属内
THEMIS Q8N1K5 GRB2 Homo sapiens P62993
Pull Down
21189249
种属内
THEMIS Q8N1K5 GRB2 Homo sapiens P62993
Pull Down
25535246
种属内
THEMIS Q8N1K5 PTPN6 Homo sapiens P29350
Pull Down
25535246
种属内
THEMIS Q8N1K5 PRMT6 Homo sapiens Q96LA8
Y2H
23455924
种属内
THEMIS Q8N1K5 PRMT6 Homo sapiens Q96LA8
Anti Tag CoIP
23455924
种属间
THEMIS Q8N1K5 HBZ Human T-cell leukemia virus 1 P0C745
Anti Tag CoIP
28046066
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Developmental Coordination Disorder

Motor Skills Disorders
Lynch Syndrome I

Lynch Syndrome 1

Colorectal Cancer, Hereditary Nonpolyposis, Type 1

HNPCC1

Fcc1

Lynch Syndrome Ii

Colon Cancer, Familial Nonpolyposis, Type 1

Coca1

Familial Nonpolyposis Colon Cancer Type 1

Hereditary Nonpolyposis Colorectal Cancer Type 1

Hereditary Non-Polyposis Colorectal Cancer 1

Hereditary Non-Polyposis Colorectal Cancer 3

Hnpcc3

Lynch Cancer Family Syndrome

Lynch Syndrome

Lynch Syndrome Type I

Lynch Syndrome Type Ii

Cancer, Colorectal, Nonpolyposis, Hereditary, Type 1

Hereditary Nonpolyposis Colorectal Cancer

Colorectal Cancer, Hereditary Nonpolyposis, Type 3

Hereditary Non-Polyposis Colon Cancer Type 2
Diamond-Blackfan Anemia 1

Aase Syndrome

DBA1

Erythrogenesis Imperfecta

Aase-Smith Syndrome Ii

Dba

Blackfan-Diamond Syndrome

Bds

Anemia, Congenital Hypoplastic, Of Blackfan And Diamond

Anemia, Congenital Erythroid Hypoplastic

Red Cell Aplasia, Pure, Hereditary

Aregenerative Anemia, Chronic Congenital

Rps19-Related Diamond-Blackfan Anemia

Chronic Congenital Aregenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Pure Hereditary Red Cell Aplasia

Anemia, Diamond-Blackfan, Type 1

Anemia, Diamond-Blackfan

Aase Smith Syndrome 2

Familial Hypoplastic Anaemia With Malformations

Constitutional Pure Red Cell Aplasia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14488 THEMIS Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14489 THEMIS2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus THEMIS MGD MGI:2443552
Felis catus THEMIS VGNC VGNC:66161
Macaca mulatta THEMIS VGNC VGNC:83496
Bos taurus THEMIS VGNC VGNC:35835
Rattus norvegicus THEMIS RGD RGD:1560849
Canis familiaris THEMIS VGNC VGNC:47343
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