1. Gene
  2. TYK2 - tyrosine kinase 2 Gene

TYK2 - tyrosine kinase 2 Gene

中文名称:酪氨酸激酶 2

种属: Homo sapiens

同用名: JTK1; IMD35

基因 ID: 7297 | 基因类型: protein coding

关于 TYK2

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,350,533-10,380,572 (from NCBI)

This gene has 35 transcripts (splice variants), 197 orthologues, 32 paralogues and is associated with 4 phenotypes. Ubiquitous expression in spleen (RPKM 21.6), bone marrow (RPKM 20.9) and 25 other tissues.

功能概要

该基因编码酪氨酸激酶的一个成员,更具体地说,编码 Janus 激酶 (JAKs) 蛋白家族。该蛋白与 I 型和 II 型细胞因子受体的细胞质结构域结合,并通过磷酸化受体亚基发出细胞因子信号。它也是 I 型和 III 型干扰素信号通路的组成部分。因此,它可能在抗病毒免疫中发挥作用。该基因的突变与免疫缺陷 35 有关。[RefSeq 提供,2020 年 9 月]

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II Cytokine Receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35. [provided by RefSeq, Sep 2020]

TYK2 基因产物(21)

mRNA Protein Name
NM_001385200.1 NP_001372129.1 non-receptor tyrosine-protein kinase TYK2 isoform 6
NM_001385197.1 NP_001372126.1 non-receptor tyrosine-protein kinase TYK2 isoform 3
NM_001385204.1 NP_001372133.1 non-receptor tyrosine-protein kinase TYK2 isoform 1
NM_001385199.1 NP_001372128.1 non-receptor tyrosine-protein kinase TYK2 isoform 5
NM_001406461.1 NP_001393390.1 non-receptor tyrosine-protein kinase TYK2 isoform 2
XM_047439305.1 XP_047295261.1 non-receptor tyrosine-protein kinase TYK2 isoform X4
NM_001385202.1 NP_001372131.1 non-receptor tyrosine-protein kinase TYK2 isoform 8
NM_001385206.1 NP_001372135.1 non-receptor tyrosine-protein kinase TYK2 isoform 11
XM_011528249.3 XP_011526551.1 non-receptor tyrosine-protein kinase TYK2 isoform X5
NM_001385201.1 NP_001372130.1 non-receptor tyrosine-protein kinase TYK2 isoform 7
XM_011528245.2 XP_011526547.1 non-receptor tyrosine-protein kinase TYK2 isoform X1
NM_003331.5 NP_003322.3 non-receptor tyrosine-protein kinase TYK2 isoform 2
XM_047439304.1 XP_047295260.1 non-receptor tyrosine-protein kinase TYK2 isoform X2
NM_001385207.1 NP_001372136.1 non-receptor tyrosine-protein kinase TYK2 isoform 12
XM_047439307.1 XP_047295263.1 non-receptor tyrosine-protein kinase TYK2 isoform X7
XM_011528246.4 XP_011526548.1 non-receptor tyrosine-protein kinase TYK2 isoform X3
XM_011528247.2 XP_011526549.1 non-receptor tyrosine-protein kinase TYK2 isoform X3
NM_001385205.1 NP_001372134.1 non-receptor tyrosine-protein kinase TYK2 isoform 10
XM_047439306.1 XP_047295262.1 non-receptor tyrosine-protein kinase TYK2 isoform X6
NM_001385203.1 NP_001372132.1 non-receptor tyrosine-protein kinase TYK2 isoform 9
NM_001385198.1 NP_001372127.1 non-receptor tyrosine-protein kinase TYK2 isoform 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables growth hormone receptor binding IPI
IPI: 通过物理相互作用推断
10502458 GOA
enables non-membrane spanning protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
7526154 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21516116 GOA
enables protein tyrosine kinase activity EXP
EXP: 通过实验结果推断
1386289 GOA
enables protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
10542297 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
10502458 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10502458 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TYK2 蛋白结构

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (591 - 866)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (897 - 1167)

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  • 1187 a.a.
蛋白主名 其他名称

non-receptor tyrosine-protein kinase TYK2

TYK2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TYK2 P29597 KRT40 Homo sapiens Q6A162 25416956
种属内
TYK2 P29597 TP53BP2 Homo sapiens Q05BL1 32296183
种属内
TYK2 P29597 TP53BP2 Homo sapiens Q05BL1 32296183
种属内
TYK2 P29597 TP53BP2 Homo sapiens Q05BL1 32296183
种属内
TYK2 P29597 PRDM5 Homo sapiens Q9NQX1-2 32296183
种属内
TYK2 P29597 PRDM5 Homo sapiens Q9NQX1-2 32296183
种属内
TYK2 P29597 PRDM5 Homo sapiens Q9NQX1-2 32296183
种属内
TYK2 P29597 STAT2 Homo sapiens P52630 32953130
种属内
TYK2 P29597 IFNAR1 Homo sapiens P17181-1 24704786
种属内
TYK2 P29597 IFNAR1 Homo sapiens P17181-1
GMS
24704786
种属内
TYK2 P29597 KRTAP6-3 Homo sapiens Q3LI67 32296183
种属内
TYK2 P29597 KRTAP6-3 Homo sapiens Q3LI67 32296183
种属内
TYK2 P29597 HNRNPK Homo sapiens P61978 25416956
种属内
TYK2 P29597 HNRNPK Homo sapiens P61978 25416956
种属内
TYK2 P29597 HNRNPK Homo sapiens P61978 25416956
种属内
TYK2 P29597 HNRNPK Homo sapiens P61978 29892012
种属内
TYK2 P29597 HSP90AB1 Homo sapiens P08238 22939624
种属内
TYK2 P29597 AKAP8L Homo sapiens Q9ULX6 32296183
种属内
TYK2 P29597 AKAP8L Homo sapiens Q9ULX6 32296183
种属内
TYK2 P29597 AKAP8L Homo sapiens Q9ULX6 32296183
种属内
TYK2 P29597 TRAF4 Homo sapiens Q9BUZ4 25416956
种属内
TYK2 P29597 CYSRT1 Homo sapiens A8MQ03 32296183
种属内
TYK2 P29597 CYSRT1 Homo sapiens A8MQ03 32296183
种属内
TYK2 P29597 JAK2 Homo sapiens O60674 26175413
种属内
TYK2 P29597 GOLGA6L9 Homo sapiens A6NEM1 32296183
种属内
TYK2 P29597 GOLGA6L9 Homo sapiens A6NEM1 32296183
种属内
TYK2 P29597 HNRNPK Homo sapiens P61978-2 32296183
种属内
TYK2 P29597 HNRNPK Homo sapiens P61978-2 32296183
种属内
TYK2 P29597 HNRNPK Homo sapiens P61978-2 32296183
种属内
TYK2 P29597 AGR2 Homo sapiens O95994 32296183
种属内
TYK2 P29597 AGR2 Homo sapiens O95994 32296183
种属内
TYK2 P29597 KHDRBS3 Homo sapiens O75525 32296183
种属内
TYK2 P29597 KHDRBS3 Homo sapiens O75525 32296183
种属内
TYK2 P29597 FHL3 Homo sapiens Q13643 32296183
种属内
TYK2 P29597 FHL3 Homo sapiens Q13643 25416956
种属内
TYK2 P29597 FHL3 Homo sapiens Q13643 32296183
种属内
TYK2 P29597 FHL3 Homo sapiens Q13643 32296183
种属内
TYK2 P29597 KHDRBS2 Homo sapiens Q5VWX1
Y2H
21516116
种属内
TYK2 P29597 KHDRBS2 Homo sapiens Q5VWX1 32296183
种属内
TYK2 P29597 KHDRBS2 Homo sapiens Q5VWX1 25416956
种属内
TYK2 P29597 KHDRBS2 Homo sapiens Q5VWX1 32296183
种属内
TYK2 P29597 KHDRBS2 Homo sapiens Q5VWX1 32296183
种属内
TYK2 P29597 KRT31 Homo sapiens Q15323 32296183
种属内
TYK2 P29597 KRT31 Homo sapiens Q15323 32296183
种属内
TYK2 P29597 KRT31 Homo sapiens Q15323 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Fibrosarcoma

Neoplasms, Fibrous Tissue

Fibrocytic Tumor

Fibrosarcoma Of Soft Tissue

Fibrous Tissue Neoplasm

Hyper Ige Syndrome

Hyper-Ige Syndrome

Hyper Immunoglobulin E Syndrome

Hies

Hyper-Ige Recurrent Infection Syndrome

Hyperimmunoglobulin E Syndrome

Hyper Ige

Job Syndrome

Hartnup Disease

Severe Combined Immunodeficiency

Scid

Severe Combined Immunodeficiency Disease

Combined T And B Cell Inborn Immunodeficiency

Immunodeficiency, Severe Combined

Scid - [Severe Combined Immunodeficiencies]

Pneumonia

Acute Pneumonia

Pneumonias

Infectious Pneumonia

Pn - [Pneumonia]

Lobar Pneumonia Nos

Multifocal Pneumonia

Orthostatic Pneumonia

Pneumonia Nos

Chronic Pneumonia Nos

Atypical Pneumonia

Passive Pneumonia

Purulent Pneumonia

Interstitial Lobar Pneumonia

Pneumonia, Unspecified

Pneumonia Due To Chlamydia

Pneumonia Due To Chlamydia Pneumoniae

Pneumonia Due To E. Coli

Escherichia Coli Lobar Pneumonia

Pneumonia Due To H. Influenzae

Pneumonia Due To Hemophilus Influenzae

Bronchopneumonia Due To H. Influenzae

Haemophilus Influenzae Lobar Pneumonia

Bronchopneumonia Due To Hemophilus Influenzae

Pseudomonal Pneumonia

Pseudomonas Pneumonia

Pseudomonas Lobar Pneumonia

Staphylococcal Pneumonia

Staphylococcus Pneumonia

Acute Staphylococcal Pneumonia

Staphylococcal Double Pneumonia

Staphylococcal Lobar Pneumonia

Staphylococcal Purulent Pneumonia

Staphylococcal Bronchopneumonia

Pneumococcal Pneumonia

Pneumococcus Pneumonia

Bronchopneumonia Due To S. Pneumoniae

Pneumococcal Lobar Pneumonia

Streptococcal Pneumoniae Pneumonia

Streptococcus Pneumoniae Lobar Pneumonia

Pyemic Pneumococcal Embolism With Pneumonia

Bronchopneumonia Due To Streptococcus Pneumoniae

Pneumonia Due To Streptococcus, Group B

Group B Streptococcal Pneumonia

Adenovirus Pneumonia

Adenoviral Pneumonia

Adenovirus Viral Pneumonia

Pneumonia Respiratory Syncytial Viral

Parainfluenza Viral Pneumonia

Parainfluenzal Pneumonia

Parainfluenza Virus Pneumonia

Human Metapneumovirus Pneumonia

Human Metapneumovirus Infection Resulting In Pneumonia

Pneumocystis Pneumonia

Plasma Cells Pneumonia

Nail Disease

Nail Diseases

Abnormality Of The Nail

Nail Anomaly

Alopecia Universalis Congenita

Alopecia Universalis

ALUNC

Atrichia, Generalized

Au

Alopecia Areata Universalis

Atrichia Generalized

Hyper Ige Recurrent Infection Syndrome 1

Job Syndrome

Hyper-Ige Recurrent Infection Syndrome 1

Hyperimmunoglobulin E Syndrome

Job'S Syndrome

Recurring Cold Staphylococcal Abscesses

Ige Syndromes

Buckley Syndrome

Hie - [Hyperimmunoglobulin E] Syndrome

Job-Buckley Syndrome

Quie-Hill Syndrome

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous

Cmc

Candidiasis Chronic Mucocutaneous

Polycythemia Vera

PV

Polycythemia Rubra Vera

Prv

Osler-Vaquez Disease

Chronic Erythremia

Polycythaemia Rubra Vera

Primary Polycythemia

Vaquez Disease

Polycythemia Vera, Somatic

Osler-Vaquez Syndrome

Proliferative Polycythaemia

Polycythemia Ruba Vera

Acquired Primary Erythrocytosis

Heilmeyer-Schoner Disease

Vaquez Osler Disease

Primary Polycythaemia

Psoriatic Arthritis

Psoriatic Arthritis, Susceptibility To

Psoriatic Arthropathy

Arthropathic Psoriasis

Arthritis, Psoriatic

Arthritis Psoriatica

PSORAS

Arthritic Psoriasis

Psoriasis Arthropathica

Arthritis Psoriatic

Arthritis, Psoriatic, Susceptibility To

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Encephalopathy With Basal Ganglia Calcification

Aicardi-Goutières Syndrome

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1

Chilblain Lupus 1

Chilblain Lupus

CHBL1

Chilblain Lupus Erythematosus

Chle

Hutchinson Lupus

Chilblain Lupus, Type 1

Myeloproliferative Neoplasm

Myeloproliferative Disorder

Chronic Myeloproliferative Disease

Myeloproliferative Neoplasms

Chronic Myeloproliferative Disorder

Cmpd

Cmpd, U

Chronic Myeloproliferative Disorders

Mpd

Mpn

Myeloproliferative Disorders

Myeloproliferative Disease

Campomelic Dysplasia

Immunodeficiency 35

Tyrosine Kinase 2 Deficiency

IMD35

Tyk2 Deficiency

Autosomal Recessive Hyper-Ige Syndrome With Atypical Mycobacteriosis

Susceptibility To Infection Due To Tyk2 Deficiency

Hyper-Ige Syndrome With Atypical Mycobacteriosis, Autosomal Recessive

Hies With Atypical Mycobacteriosis, Autosomal Recessive

Autosomal Recessiv Hies With Atypical Mycobacteriosis

Autosomal Recessive Hyper-Ige Syndrome Due To Tyk2 Deficiency

Autosomal Recessive Hies With Atypical Mycobacteriosis

Hepatitis

Chronic Hepatitis

Chronic Persistent Hepatitis

Acute Hepatitis

Hepatitis, Chronic

Acute And Subacute Liver Necrosis

Acute/Subac. Necrosis Of Liver

Animal Hepatitis

Hepatitis Chronic

Hepatitis A

Hepatitis, Animal

Hepatitis Due To Toxoplasmosis

Hepatitis In Toxoplasmosis

Toxoplasmal Hepatitis

Chronic Hepatitis, Unspecified

Chronic Active Hepatitis Nec

Other Specified Chronic Hepatitis

Chronic Persistent Hepatitis Nec

Chronic Lobular Hepatitis Nec

Autoimmune Disease Of Skin And Connective Tissue
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Behcet Syndrome

Behcet Disease

Behcet'S Syndrome

Behcet'S Disease

Behçet Disease

Bd

Adamantiades-Behcet Disease

Triple Symptom Complex

Behet'S Syndrome

Bd Syndrome

Behçet Syndrome

Behçet'S Disease

Behçet'S Syndrome

Behcet Triple Symptom Complex

Malignant Aphthosis

Old Silk Route Disease

Adamantiades-Behçet Disease

B Cell Deficiency

Immunoglobulin Heavy Chain Deficiency

B Cell Deficiencies

Immunoglobulin Heavy Chain Deletion

Humoral Immune Defect

Primary Cutaneous Anaplastic Large Cell Lymphoma

Primary C-Alcl

Regressive Atypical Histiocytosis

Lymphoma, Primary Cutaneous Anaplastic Large Cell

Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Essential Thrombocythemia

Essential Thrombocytosis

Familial Thrombocytosis

Hemorrhagic Thrombocythemia

Hereditary Thrombocythemia

Primary Thrombocytosis

Idiopathic Thrombocythemia

Primary Thrombocythemia

Thrombocythemia, Essential

Essential Thrombocythaemia

Et

Familial Thrombocythemia

Thrombocythemia Essential

Crisponi/Cold-Induced Sweating Syndrome 2

Cold-Induced Sweating Syndrome 2

CISS2

Sweating Syndrome, Cold-Induced, Type 2

Lymphoproliferative Syndrome, X-Linked, 1

Lymphomatoid Papulosis

Duncan Disease

Purtilo Syndrome

X-Linked Lymphoproliferative Syndrome

Xlp

XLP1

Lyp

X-Linked Lymphoproliferative Disease

Lymphoproliferative Disease, X-Linked

Xlpd

X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency

Ebv Infection, Severe, Susceptibility To

Ebvs

Immunodeficiency 5

Imd5

X-Linked Lymphoproliferative Syndrome 1

Epstein-Barr Virus Infection, Familial Fatal

Ebv Infection, Severe

Infectious Mononucleosis, Severe

Infectious Mononucleosis, Severe, Susceptibility To

Immunodeficiency, X-Linked Progressive Combined Variable

Epstein Barr Virus Infection, Familial Fatal

X-Linked Progressive Combined Variable Immunodeficiency 5

Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males

Familial Fatal Epstein-Barr Infection

Severe Susceptibility To Ebv Infection

Severe Susceptibility To Infectious Mononucleosis

Sap Deficiency

Sh2d1a/Slam-Associated Protein Deficiency

X-Linked Lymphoproliferative Syndrome Type 1

X-Linked Progressive Combined Variable Immunodeficiency

Lymphoproliferative Syndrome, X-Linked

Sap

X-Linked Lymphoproliferative Disorder

Myeloma, Multiple

Multiple Myeloma

Kahler Disease

Myelomatosis

Plasma Cell Myeloma

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler'S Disease

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]

Lymphopenia

Lymphocytopenia

Erythematosquamous Dermatosis

Other Erythematosquamous Dermatosis

Nasopharyngitis

Chronic Nasopharyngitis

Chronic Rhinopharyngitis

Skin Disease

Skin Diseases

Abnormality Of The Skin

Skin Diseases, Genetic

Genodermatosis

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Mixed Lacrimal Gland Cancer

Carcinoma Ex Pleomorphic Adenoma Of Lacrimal Gland

Carcinoma Ex Pleomorphic Adenoma Of The Lacrimal Gland

Malignant Mixed Neoplasm Of Lacrimal Gland

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TYK2 VGNC VGNC:78680
Mus musculus TYK2 MGD MGI:1929470
Felis catus TYK2 VGNC VGNC:66736
Rattus norvegicus TYK2 RGD RGD:2320469
Canis familiaris TYK2 VGNC VGNC:48024
Bos taurus TYK2 VGNC VGNC:36548
Others TYK2 NCBI