2. Protein Tyrosine Kinase/RTK JAK/STAT Signaling Epigenetics Stem Cell/Wnt
  3. Btk JAK
  4. JAK3/BTK-IN-6

JAK3/BTK-IN-6 (化合物 14h) 是一种有效的 BTK 和 JAK3 双抑制剂，其 IC50 值分别为 0.6 和 0.4 nM。JAK3/BTK-IN-6 在人肝微粒体中具有良好的代谢稳定性。JAK3/BTK-IN-6 可用于血液和免疫疾病的研究。

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JAK3/BTK-IN-6 Chemical Structure

JAK3/BTK-IN-6 Chemical Structure

CAS No. : 2243136-03-8

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JAK3/BTK-IN-6 相关抗体

Top Publications Citing Use of Products

查看 JAK 亚型特异性产品:

查看所有亚型
JAK1 JAK2 JAK3 Tyk2 JAK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JAK3/BTK-IN-6 (compound 14h) is a potent BTK and JAK3 dual inhibitor, with IC50 values of 0.6 and 0.4 nM, respectively. JAK3/BTK-IN-6 shows good metabolic stability in human liver microsome. JAK3/BTK-IN-6 can be used for hematological and immune diseases research[1].

IC50 & Target

JAK3

0.4 nM (IC50)

JAK2

657.9 nM (IC50)

JAK1

>1000 nM (IC50)

Tyk2

>1000 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEL IC50
1.1 μM
Compound: 14h
Antiproliferative activity against human HEL cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HEL cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 31843459]
JeKo-1 IC50
0.5 μM
Compound: 14h
Antiproliferative activity against human JeKo1 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human JeKo1 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 31843459]
OCI-Ly10 IC50
1 μM
Compound: 14h
Antiproliferative activity against human OCI-LY10 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human OCI-LY10 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 31843459]
Raji IC50
1.7 μM
Compound: 14h
Antiproliferative activity against human Raji cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human Raji cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 31843459]
Ramos IC50
0.5 μM
Compound: 14h
Antiproliferative activity against human Ramos cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human Ramos cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 31843459]
体外研究
(In Vitro)

JAK3/BTK-IN-6 (compound 14h) shows antiproliferative activities against hematopoietic cells (Raji, Romas, HEL, Jeko-1, and OCI-LY10), with IC50 values of 1.7, 0.5, 1.1, 0.5, and 1-10, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JAK3/BTK-IN-6 相关抗体:
分子量

455.20

Formula

C21H17BF3N5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JAK3/BTK-IN-6 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JAK3/BTK-IN-62243136-03-8BtkJAKBruton tyrosine kinaseJanus kinaseantiproliferativehematopoietic cellRajiRomasHELJeko-1OCI-LY10immune diseasesInhibitorinhibitorinhibit

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