2. Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt
  3. JAK
  4. Pacritinib hydrochloride

Pacritinib hydrochloride  (Synonyms: SB1518 hydrochloride)

目录号: HY-16379A
产品使用指南

摩尔计算器

Pacritinib hydrochloride 是一种有效的野生型 JAK2 和 JAK2V617F 突变型抑制剂，IC50 分别为 23 nM 和 19 nM。Pacritinib hydrochloride 也抑制 FLT3 及其突变型 FLT3D835Y，IC50 分别为 22 nM 和 6 nM。Pacritinib hydrochloride 可用于急性髓系白血病(AML)和骨髓纤维化(MF)的研究。

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Pacritinib hydrochloride Chemical Structure

Pacritinib hydrochloride Chemical Structure

CAS No. : 1228923-43-0

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Pacritinib hydrochloride 的其他形式现货产品:

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Pacritinib hydrochloride 相关抗体

Top Publications Citing Use of Products

    Pacritinib hydrochloride purchased from MCE. Usage Cited in: Nat Med. 2017 Nov;23(11):1319-1330.  [Abstract]

    Pacritinib effectively disrupts the S100A7/8/9–IRAK1 feedback loop to inhibit tumorsphere growth. Representative western blot (n=2) showing inhibition of phosphorylated IRAK1 and phosphorylated JAK2 (pJAK2) within 6 h of Pacritinib treatment in MB468 and MB231 cells. Actin is used as a loading control.

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    JAK1 JAK2 JAK3 Tyk2 JAK

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Pacritinib hydrochloride is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). Pacritinib hydrochloride also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM). Pacritinib hydrochloride can be used for the research of acute myeloid leukemia (AML) and myelofibrosis (MF)[1][2][3].

    IC50 & Target

    JAK2V617F

    19 nM (IC50)

    JAK2wt

    23 nM (IC50)

    Tyk2

    50 nM (IC50)

    JAK3

    520 nM (IC50)

    JAK1

    1280 nM (IC50)

    Clinical Trial
    Formula

    C28H32N4O3.xClH
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Pacritinib hydrochloride 相关分类

    • 摩尔计算器

    • 稀释计算器

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Pacritinib1228923-43-0SB1518SB 1518SB-1518JAKJanus kinaseMyeloidleukemialymphoid malignanciesmyelofibrosiInhibitorinhibitorinhibit

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