2. Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt
  3. JAK FLT3
  4. Pacritinib citrate

Pacritinib citrate  (Synonyms: SB1518 citrate)

目录号: HY-16379B
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Pacritinib (SB1518) citrate 是一种有效的野生型 JAK2 和 JAK2V617F 突变型抑制剂，IC50 分别为 23 nM 和 19 nM。Pacritinib citrate 也抑制 FLT3 及其突变型 FLT3D835Y，IC50 分别为 22 nM 和 6 nM。Pacritinib citrate 可用于急性髓系白血病(AML)和骨髓纤维化(MF)的研究。

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Pacritinib citrate Chemical Structure

Pacritinib citrate Chemical Structure

CAS No. : 1228923-42-9

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Pacritinib citrate 相关抗体

Top Publications Citing Use of Products

    Pacritinib citrate purchased from MCE. Usage Cited in: Nat Med. 2017 Nov;23(11):1319-1330.  [Abstract]

    Pacritinib effectively disrupts the S100A7/8/9–IRAK1 feedback loop to inhibit tumorsphere growth. Representative western blot (n=2) showing inhibition of phosphorylated IRAK1 and phosphorylated JAK2 (pJAK2) within 6 h of Pacritinib treatment in MB468 and MB231 cells. Actin is used as a loading control.

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    生物活性

    Pacritinib (SB1518) citrate is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). Pacritinib citrate also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM). Pacritinib citrate can be used for the research of acute myeloid leukemia (AML) and myelofibrosis (MF)[1][2][3].

    分子量

    664.70

    Formula

    C34H40N4O10
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Pacritinib citrate 相关分类

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Pacritinib1228923-42-9SB1518SB 1518SB-1518JAKFLT3Janus kinaseCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Inhibitorinhibitorinhibit

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