2. MAPK/ERK Pathway Immunology/Inflammation Metabolic Enzyme/Protease JAK/STAT Signaling Stem Cell/Wnt Epigenetics Protein Tyrosine Kinase/RTK
  3. Interleukin Related p38 MAPK STAT Cathepsin JAK
  4. Dual Cathepsin L/JAK-IN-1

Dual Cathepsin L/JAK-IN-1 (Compound A8) 是 Cathepsin L (CTSL) 和 JAK 的双重抑制剂，其对 CTSL、JAK1/2/3 和 TYK2 的 IC50 值分别为 0.68 μM、337.1 nM、5.251 nM、27.29 nM 和 172.6 nM。Dual Cathepsin L/JAK-IN-1 能有效阻断 MAPK、NF-κB 和 JAK/STAT 信号通路的激活，从而产生了显著的抗炎治疗效果。Dual Cathepsin L/JAK-IN-1 可以用于急性肺损伤 (ALI) 的研究。

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Dual Cathepsin L/JAK-IN-1 Chemical Structure

Dual Cathepsin L/JAK-IN-1 Chemical Structure

CAS No. : 2450279-41-9

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Dual Cathepsin L/JAK-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 STAT 亚型特异性产品:

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STAT3 STAT5 STAT6 STAT1

查看 Cathepsin 亚型特异性产品:

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Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

查看 JAK 亚型特异性产品:

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JAK1 JAK2 JAK3 Tyk2 JAK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dual Cathepsin L/JAK-IN-1 (Compound A8) is a dual inhibitor of Cathepsin L (CTSL) and JAK, with IC50 values of 0.68 μM, 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for CTSL, JAK1/2/3, and TYK2, respectively. Dual Cathepsin L/JAK-IN-1 effectively blocks the activation of the MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. Dual Cathepsin L/JAK-IN-1 can be used in research on acute lung injury (ALI)[1].

IC50 & Target[1]

cathepsin L

0.68 μM (IC50)

JAK1

337.1 nM (IC50)

JAK2

5.251 nM (IC50)

JAK3

27.29 nM (IC50)

Tyk2

172.6 nM (IC50)

分子量

351.83

Formula

C19H18ClN5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dual Cathepsin L/JAK-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dual Cathepsin L/JAK-IN-12450279-41-9Interleukin Relatedp38 MAPKSTATCathepsinJAKILJanus kinaseAcute lung injury (ALI)HBE Cellsraw264.7 cellsInflammationInhibitorinhibitorinhibit

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