2. Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt
  3. JAK
  4. Peficitinib hydrochloride

Peficitinib hydrochloride  (Synonyms: ASP015K hydrochloride; JNJ-54781532 hydrochloride)

目录号: HY-19568B
产品使用指南

摩尔计算器

Peficitinib (ASP015K) hydrochloride 是一种具有口服活性的 JAK 抑制剂，对 JAK1、JAK2、JAK3 和 Tyk2 的 IC50 值分别为 3.9、5.0、0.7 和 4.8 nM。

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Peficitinib hydrochloride Chemical Structure

Peficitinib hydrochloride Chemical Structure

CAS No. : 1353219-06-3

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Peficitinib hydrochloride 的其他形式现货产品:

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Other Forms of Peficitinib hydrochloride:

Peficitinib hydrochloride 相关抗体

Top Publications Citing Use of Products

    Peficitinib hydrochloride purchased from MCE. Usage Cited in: Cells. 2019 Jun 9;8(6). pii: E561.  [Abstract]

    Effects of Peficitinib on IL-6 and IL-6R responses in RA FLS. The RA FLS are stimulated with IL-6 (100 ng/mL) and IL-6R (100 ng/mL) after treating with Peficitinib (0.1, 1, 5 μM) for 24 h. Representative western blot images showed that peficitinib suppressed the phosphorylation of STAT1, STAT3, and STAT5 in RA FLS.

    Peficitinib hydrochloride purchased from MCE. Usage Cited in: Cancer Manag Res. 2018 Dec 28;11:389-399.  [Abstract]

    Western blotting analysis of the protein levels of JAK1 and caspase-3 in different treated NSP cells: Lentiv-NC (48 hours), Lentiv-OCT4 (48 hours), and peficitinib (4.8 nM, 2 hours) + Lentiv-OCT4 (48 hours). Left: SKOV3 cells, right: A2780 cells.

    查看 JAK 亚型特异性产品:

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    JAK1 JAK2 JAK3 Tyk2 JAK

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Peficitinib (ASP015K) hydrochloride is an orally active JAK inhibitor, with IC50s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively[1].

    IC50 & Target[1]

    JAK3

    0.7 nM (IC50)

    JAK1

    3.9 nM (IC50)

    Tyk2

    4.8 nM (IC50)

    JAK2

    5 nM (IC50)

    体外研究
    (In Vitro)

    Peficitinib hydrobromide (0-100 nM; 3 days) inhibits IL-2-induced T cell proliferation in a concentration-dependent manner[1].
    Peficitinib hydrobromide (10-1000 nM) inhibits IL-2-induced STAT5 phosphorylation in a concentration-dependent manner with a mean IC50 of 124 nM in rat whole blood, and inhibits STAT5 phosphorylation with a mean IC50 of 127 nM in human lymphocytes[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Peficitinib hydrochloride 相关抗体:

    Cell Proliferation Assay[1]

    Cell Line: Splenocytes from male Lewis rats
    Concentration: 0-100 nM
    Incubation Time: 3 days
    Result: Inhibited IL-2-induced T cell proliferation in a concentration-dependent manner with an IC50 of 10 nM.
    体内研究
    (In Vivo)

    Peficitinib hydrobromide (1-30 mg/kg; p.o.; once daily for 24 days) shows dose-dependent efficacy both in prophylactic and therapeutic dosing regimens in an adjuvant-induced arthritis rat model[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Seven-weeks-old female Lewis rats, adjuvant-induced arthritis (AIA) model[1]
    Dosage: 1, 3, 10, and 30 mg/kg
    Administration: Oral administration, once daily for 24 days
    Result: Significantly inhibited the increase in paw volume at doses of 1 mg/kg or greater with an ED50 value of 2.7 mg/kg (95% confidence interval: 1.5–4.2 mg/kg). Significantly reduced the bone destruction score at 10 mg/kg or greater and almost fully ameliorated both paw swelling and bone destruction scores at 30 mg/kg.
    Clinical Trial
    分子量

    362.85

    Formula

    C18H23ClN4O2
    CAS 号
    中文名称

    盐酸佩非西替尼
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Peficitinib hydrochloride 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

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    质量   浓度   体积   分子量 *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Peficitinib1353219-06-3ASP015KJNJ-54781532盐酸佩非西替尼JNJ54781532JNJ 54781532JAKJanus kinaserheumatoid arthritisIL-2splenocyteslymphocytesInhibitorinhibitorinhibit

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