RFX3 - regulatory factor X3 Gene

中文名称：调节因子 X3

种属: Homo sapiens

基因 ID: 5991 | 基因类型: protein coding

关于 RFX3

Cytogenetic location: 9p24.2 Genomic coordinates (GRCh38): 9:3,218,297-3,526,001 (from NCBI)

This gene has 12 transcripts (splice variants), 207 orthologues and 7 paralogues. Broad expression in testis (RPKM 2.7), brain (RPKM 2.6) and 24 other tissues.

功能概要

该基因是调节因子 X 基因家族的成员，它编码的转录因子包含一个高度保守的有翼螺旋 DNA 结合域。该基因编码的蛋白质在结构上与调节因子 X1、X2、X4 和 X5 相关。它是一种转录激活剂，可以作为单体或作为异源二聚体与其他 RFX 家族成员结合 DNA。已针对该基因描述了编码不同亚型的多个转录变体。[RefSeq 提供，2013 年 8 月]

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]

RFX3 基因产物(5)

mRNA	Protein	Name
NM_001282116.2	NP_001269045.1	transcription factor RFX3 isoform b
NM_001282117.2	NP_001269046.1	transcription factor RFX3 isoform c
NM_001377999.1	NP_001364928.1	transcription factor RFX3 isoform d
NM_002919.4	NP_002910.1	transcription factor RFX3 isoform a
NM_134428.3	NP_602304.1	transcription factor RFX3 isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	20148032	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	12411430	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	20148032	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromatin	IDA IDA: 通过直接分析推断	20413507	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RFX3 蛋白结构

RFX1_trans_act

RFX_DNA_binding

0
200
400
600
749 a.a.

蛋白主名

其他名称

transcription factor RFX3

DNA binding protein RFX3

RFX3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	RFX3	P48380	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	RFX3	P48380	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	RFX3	P48380	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	RFX3	P48380	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
Intra	RFX3	P48380	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	RFX3	P48380	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	RFX3	P48380	TRAF2	Homo sapiens	Q12933	Y2H Pooling	16189514
Intra	RFX3	P48380	FHL2	Homo sapiens	Q14192	Y2H Array	31515488
Intra	RFX3	P48380	FHL2	Homo sapiens	Q14192	Validated Y2H	32296183
Intra	RFX3	P48380	FHL2	Homo sapiens	Q14192	Y2H Array	25416956
Intra	RFX3	P48380	FHL2	Homo sapiens	Q14192	Y2H Prey Pooling	32296183
Intra	RFX3	P48380	FHL2	Homo sapiens	Q14192	Y2H Array	32296183
Intra	RFX3	P48380	FHL3	Homo sapiens	Q13643	Validated Y2H	25416956
Intra	RFX3	P48380	FHL3	Homo sapiens	Q13643	Y2H Array	31515488
Intra	RFX3	P48380	TRIP6	Homo sapiens	Q15654	Y2H Prey Pooling	25416956
Intra	RFX3	P48380	TRIP6	Homo sapiens	Q15654	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Alstrom Syndrome

ALMS	Alström Syndrome
Alss	Alstrom-Hallgren Syndrome
Alstroem Syndrome

Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 2	PKD2
Polycystic Kidney Disease, Adult, Type Ii	Apkd2
Polycystic Kidney Disease, Type 2	Adpkd2
Adult Polycystic Kidney Disease Type 2	Autosomal Dominant Polycystic Kidney Disease 2
Pkd-2	Polycystic Kidney Disease Adult Type Ii
Polycystic Kidney Type 2 Autosomal Dominant Disease	Kidney Disease, Polycystic, Type 2

Myoclonic Epilepsy Associated With Ragged-Red Fibers

Merrf Syndrome	MERRF
Fukuhara Syndrome	Myoclonic Epilepsy Associated With Ragged Red Fibers
Myoencephalopathy Ragged-Red Fiber Disease	Myoclonic Epilepsy - Ragged Red Fibers
Myoclonus Epilepsy And Ragged Red Fibers	Myoclonus With Epilepsy And With Ragged Red Fibers
Myoclonic Epilepsy With Ragged Red Fibers	Myoclonic Epilepsy With Ragged-Red Fibers
Fukuhara Disease	Myoclonus Epilepsy Associated With Ragged-Red Fibres
Myoclonus With Epilepsy With Ragged Red Fibers

Visceral Heterotaxy

Situs Ambiguus	Heterotaxia
Heterotaxy Syndrome	Heterotaxy
Lateralization Defect	Situs Ambiguous
Left Isomerism	Htx
Ivemark Syndrome	Right Isomerism
Situs Ambiguus Viscerum	Incomplete Situs Inversus
Partial Situs Inversus	Heterotaxy, Visceral
Asplenia Syndrome	Bilateral Left-Sidedness
Polysplenia Syndrome	Moller Syndrome

Situs Inversus

Situs Inversus Viscerum	Laterality Sequence
Complete Transposition	Siv

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11881	RFX3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	RFX3	VGNC	VGNC:45505
Felis catus	RFX3	VGNC	VGNC:69305
Mus musculus	RFX3	MGD	MGI:106582
Bos taurus	RFX3	VGNC	VGNC:33895
Rattus norvegicus	RFX3	RGD	RGD:1307779
Macaca mulatta	RFX3	VGNC	VGNC:76908

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RFX3 - regulatory factor X3 Gene

关于 RFX3

功能概要

RFX3 基因产物(5)

RFX3 蛋白结构

RFX3 蛋白互作信息

关联疾病

直系同源

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RFX3 - regulatory factor X3 Gene

关于 RFX3

功能概要

RFX3 基因产物(5)

RFX3 蛋白结构

RFX3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z