2. Gene
  3. FOXN4 - forkhead box N4 Gene

FOXN4 - forkhead box N4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：叉头盒 N4

种属: Homo sapiens

基因 ID: 121643 | 基因类型: protein coding

关于 FOXN4

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:109,277,978-109,309,284 (from NCBI)

This gene has 4 transcripts (splice variants), 221 orthologues and 2 paralogues. Restricted expression toward testis (RPKM 2.5).

功能概要

有翼螺旋/叉头转录因子家族的成员，例如 FOXN4，具有 110 个氨基酸的 DNA 结合结构域，可以折叠成螺旋-转角-螺旋基序的变体，该基序由侧翼为 2 个大环或翅膀。这些转录因子作为发育和新陈代谢的关键调节因子参与多种生物过程 (Li et al., 2004 [PubMed 15363391]) 。[OMIM 提供，2008 年 3 月]

Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. These transcription factors are involved in a variety of biologic processes as key regulators in development and metabolism (Li et al., 2004 [PubMed 15363391]).[supplied by OMIM, Mar 2008]

FOXN4 基因产物(1)

mRNA Protein Name
NM_213596.3 NP_998761.2 forkhead box protein N4
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
22323600 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
27107012 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FOXN4 蛋白结构

Forkhead

Forkhead: Forkhead domain (193 - 283)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 517 a.a.
蛋白主名 其他名称

forkhead box protein N4

forkhead/winged helix transcription factor FOXN4

FOXN4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FOXN4 Q96NZ1 AMY1A Homo sapiens P0DTE7
Anti Tag CoIP
33961781
种属内
FOXN4 Q96NZ1 AMY1A Homo sapiens P0DTE7
Anti Tag CoIP
28514442
种属内
FOXN4 Q96NZ1 FHL3 Homo sapiens Q13643
Validated Y2H
27107012
种属内
FOXN4 Q96NZ1 RFX2 Homo sapiens P48378
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Lymphedema-Distichiasis Syndrome

Lymphedema With Distichiasis

Lymphedema-Distichiasis Syndrome With Renal Disease And Diabetes Mellitus

LPHDST

Distichiasis-Lymphedema Syndrome

Lymphedema Distichiasis Syndrome

Hereditary Lymphedema-Distichiasis Syndrome

Lymphedema Distichiasis
Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05068 FOXN4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus FOXN4 VGNC VGNC:62342
Rattus norvegicus FOXN4 RGD RGD:1306389
Macaca mulatta FOXN4 VGNC VGNC:82146
Canis familiaris FOXN4 VGNC VGNC:40962
Mus musculus FOXN4 MGD MGI:2151057
Bos taurus FOXN4 VGNC VGNC:29097
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