2. Gene
  3. HDAC7 - histone deacetylase 7 Gene

HDAC7 - histone deacetylase 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：组蛋白脱乙酰酶 7

种属: Homo sapiens

同用名: HD7; HD7A; HDAC7A

基因 ID: 51564 | 基因类型: protein coding

关于 HDAC7

Cytogenetic location: 12q13.11 Genomic coordinates (GRCh38): 12:47,782,722-47,821,344 (from NCBI)

This gene has 30 transcripts (splice variants), 263 orthologues and 10 paralogues. Ubiquitous expression in lung (RPKM 18.9), spleen (RPKM 18.4) and 25 other tissues.

功能概要

组蛋白在转录调控、细胞周期进程和发育事件中发挥关键作用。组蛋白乙酰化/去乙酰化改变染色体结构并影响转录因子对 DNA 的访问。该基因编码的蛋白质与组蛋白脱乙酰酶家族成员具有序列同源性。该基因与小鼠 HDAC7 基因同源，其蛋白质促进通过转录辅阻遏物 SMRT 介导的抑制。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

HDAC7 基因产物(18)

mRNA Protein Name
NR_160435.1
NM_001368046.1 NP_001354975.1 histone deacetylase 7 isoform f
XM_047428983.1 XP_047284939.1 histone deacetylase 7 isoform X9
XM_011538483.1 XP_011536785.1 histone deacetylase 7 isoform X10
NM_001308090.2 NP_001295019.1 histone deacetylase 7 isoform e
XM_047428981.1 XP_047284937.1 histone deacetylase 7 isoform X7
XM_011538481.2 XP_011536783.2 histone deacetylase 7 isoform X1
XM_047428978.1 XP_047284934.1 histone deacetylase 7 isoform X2
NR_160436.1
NM_015401.5 NP_056216.2 histone deacetylase 7 isoform a
XM_047428979.1 XP_047284935.1 histone deacetylase 7 isoform X5
XM_024449018.2 XP_024304786.1 histone deacetylase 7 isoform X3
XM_047428982.1 XP_047284938.1 histone deacetylase 7 isoform X8
XM_047428984.1 XP_047284940.1 histone deacetylase 7 isoform X8
NM_016596.3
XM_011538480.1 XP_011536782.1 histone deacetylase 7 isoform X4
NM_001098416.4 NP_001091886.1 histone deacetylase 7 isoform d
XM_047428980.1 XP_047284936.1 histone deacetylase 7 isoform X6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 14-3-3 protein binding IDA
IDA: 通过直接分析推断
16980613 GOA
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
17360565 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15161933 GOA
enables protein kinase C binding IPI
IPI: 通过物理相互作用推断
20188095 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
16980613 GOA
enables protein lysine deacetylase activity IDA
IDA: 通过直接分析推断
30538141 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of interleukin-2 production IDA
IDA: 通过直接分析推断
17360565 GOA
involved in negative regulation of non-canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
25411248 GOA
involved in negative regulation of osteoblast differentiation IMP
IMP: 通过突变表型推断
17997710 GOA
involved in positive regulation of cell migration involved in sprouting angiogenesis IMP
IMP: 通过突变表型推断
19351956 GOA
involved in protein deacetylation IMP
IMP: 通过突变表型推断
30538141 GOA
involved in regulation of mRNA processing IDA
IDA: 通过直接分析推断
37369679 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
16980613 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16980613 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HDAC7 蛋白结构

Hist_deacetyl

Hist_deacetyl: Histone deacetylase domain (534 - 859)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 952 a.a.
蛋白主名 其他名称

histone deacetylase 7

histone deacetylase 7A

HDAC7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HDAC7 Q8WUI4 PRKD2 Homo sapiens Q9BZL6
Anti Tag CoIP
17962809
种属内
HDAC7 Q8WUI4 PRKD2 Homo sapiens Q9BZL6
Anti Bait CoIP
17962809
种属内
HDAC7 Q8WUI4 FOXP3 Homo sapiens Q9BZS1-2
Anti Tag CoIP
17360565
种属内
HDAC7 Q8WUI4 EGFR Homo sapiens P00533
Lumier
24658140
种属内
HDAC7 Q8WUI4 YWHAZ Homo sapiens P63104
Anti Tag CoIP
33961781
种属内
HDAC7 Q8WUI4 YWHAZ Homo sapiens P63104
CoIP
20224040
种属内
HDAC7 Q8WUI4 YWHAZ Homo sapiens P63104
Pull Down
15161933
种属内
HDAC7 Q8WUI4 YWHAZ Homo sapiens P63104
Anti Tag CoIP
23752268
种属内
HDAC7 Q8WUI4 SFN Homo sapiens P31947
TAP
15778465
种属内
HDAC7 Q8WUI4 SFN Homo sapiens P31947
Anti Tag CoIP
18339811
种属内
HDAC7 Q8WUI4 SFN Homo sapiens P31947
Anti Tag CoIP
23752268
种属内
HDAC7 Q8WUI4 FOXP3 Homo sapiens Q9BZS1-1
Anti Tag CoIP
17360565
种属间: 跨种属相互作用 种属内: 同种属相互作用

HDAC7 抗体

目录号 产品名 应用 反应物种
HY-P83401 HDAC7 Antibody (YA3146) WB, FC Human, Mouse, Rat

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10221 Vorinostat Inhibitor 99.95% 是
HY-13322 Pracinostat Inhibitor 99.82% 是
HY-14842 Givinostat Inhibitor 98.16% 是
Clinical Phase
生物活性分子 (8)
目录号 产品名 作用方式
纯度 Phase
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 98.34% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Phase 2
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1
HY-15994 Citarinostat Inhibitor 99.30% Phase 1
Pre-clinical Phase
生物活性分子 (30)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-18361 TMP195 Inhibitor 99.57% 否
HY-13428 Tubacin Inhibitor 99.54% 否
HY-18360 TMP269 Inhibitor 98.05% 否
HY-N6735 Apicidin Inhibitor 99.87% 否
HY-16699 Nexturastat A Inhibitor 98.28% 否
HY-115475 SW-100 Inhibitor 99.93% 否
HY-119939 CHDI-390576 Inhibitor 98.07% 否
HY-126330 SS-208 Inhibitor 99.00% 否
HY-149285 NT160 Inhibitor 99.58% 否
HY-117554 BRD9757 Inhibitor 99.75% 否
HY-146678 HDAC6-IN-5 Inhibitor / 否
HY-146679 HDAC6-IN-6 Inhibitor / 否
HY-150109 Purinostat mesylate Inhibitor 99.45% 否
HY-161778 ZG-126 Inhibitor / 否
HY-152226 MC2590 Inhibitor / 否
HY-150595 HDAC6-IN-10 Inhibitor / 否
HY-162630 HDAC6-IN-44 Inhibitor / 否
HY-157740 XSJ-10 Inhibitor / 否
HY-159172 HDAC3-IN-4 Inhibitor / 否
HY-162319 Tubulin/HDAC-IN-4 Inhibitor / 否
HY-124946 C1A Inhibitor / 否
HY-150774 HDAC6/HSP90-IN-2 Inhibitor / 否
HY-149208 HDAC-IN-53 Inhibitor / 否
HY-15144B (S)-Trichostatin A Inhibitor / 否
HY-152225 MC2625 Inhibitor / 否
HY-149283 JAK/HDAC-IN-2 Inhibitor / 否
HY-146684 HDAC-IN-36 Inhibitor / 否
HY-163803 CM-444 Inhibitor / 否
HY-148624 CHDI-00484077 Inhibitor / 否
HY-135714 Bavarostat Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris HDAC7 VGNC VGNC:49112
Bos taurus HDAC7 VGNC VGNC:49060
Mus musculus HDAC7 MGD MGI:1891835
Rattus norvegicus HDAC7 RGD RGD:619982
Macaca mulatta HDAC7 VGNC VGNC:99939
Felis catus HDAC7 VGNC VGNC:62770
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