2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC6-IN-44

HDAC6-IN-44 (compound H10) 是一种选择性 HDAC6 抑制剂，IC50 值为 8.97 nM，HDAC6-IN-44 能够抑制特发性肺纤化维表型，具有抗肺纤维化活性。HDAC6-IN-44 在博来霉素诱导的肺纤维化小鼠模型中被验证可抑制肺纤维化进程，且具有良好的代谢稳定性，HDAC6-IN-44 有望用于特发性肺纤化领域研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

HDAC6-IN-44 Chemical Structure

HDAC6-IN-44 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

HDAC6-IN-44 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC6-IN-44 (compound H10) is a selective HDAC6 inhibitor with an IC50 value of 8.97 nM. HDAC6-IN-44 can inhibit the idiopathic pulmonary fibrosis (IPF) phenotype and exhibits antifibrotic activity. Additionally, HDAC6-IN-44 reduces fibrogenesis in a bleomycin-induced pulmonary fibrosis mouse model and demonstrates good metabolic stability. HDAC6-IN-44 holds promise for research in the field of idiopathic pulmonary fibrosis[1].
IC50 & Target[1]

HDAC6

8.97 nM (IC50)

HDAC1

878 nM (IC50)

HDAC2

3144 nM (IC50)

HDAC4

847 nM (IC50)

HDAC7

894 nM (IC50)

HDAC10

1319 nM (IC50)

HDAC11

>5000 nM (IC50)

体外研究
(In Vitro)

HDAC6-IN-44 (compound H10) (2.5-10 μM, 1-300 μM, 48 h) 以剂量依赖的方式抑制 TGF-β 诱导的 HELF 细胞增殖、细胞活力及其 HDAC6 活性，且未引起明显的细胞毒性效应[1]。
HDAC6-IN-44 (2.5-10 μM, 48h) 通过作用于 HDAC6 相关信号通路干预 TGF-β1 相关的纤维化过程[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC6-IN-44 相关抗体:

Cell Viability Assay[1]

Cell Line: HELF cells
Concentration: 2.5-10 μM (cell proliferation test), 1-300 μM (survival toxicity test)
Incubation Time: 48 h
Result: Inhibited TGF-β-induced HELF cell proliferation without significantly inhibiting cell survival at a maximum concentration of approximately 10 μM.

Western Blot Analysis[1]

Cell Line: HELF cells
Concentration: 2.5-10 μM
Incubation Time: 48 h
Result: Exhibited dose-dependent increase in acetylated α-tubulin expression and has no effect on histone H3 acetylation, while attenuating the elevated expression of all marker proteins induced by TGF-β1.
体内研究
(In Vivo)

HDAC6-IN-44 (compound H10) (0.1 mL/10g, 腹腔注射, 每日注射持续三周) 对肺纤维化小鼠模型中肺组织 HDAC6 活性增加及胶原沉积具有显著抑制作用[1]。
HDAC6-IN-44 (0.1 mL/10g, 腹腔注射, 每日注射持续三周) 能够剂量依赖性地抑制肺纤维化小鼠模型的肺纤维化的进程[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Bleomycin-induced pulmonary fibrosis mouse model[1]
Dosage: 0.1 mL/10g
Administration: Intraperitoneal injection (i.p.) , daily for 3 weeks
Result: Caused the blue collagen fiber deposition to be spot-like, with the surrounding alveolar cavity slightly collapsed and the alveolar wall thickened, but the collagen fiber deposition was significantly less than that in the model group. Additionally, HDAC6-IN-44 could dose-dependently inhibit the expression of α-SMA and p-Smad2/3 in BLM-induced pulmonary fibrosis in mice.
分子量

351.40

Formula

C20H21N3O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC6-IN-44 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-44HDACHistone deacetylasesHELF cellsBleomycin-induced pulmonary fibrosis mouse modelIdiopathic pulmonary fibrosisInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
HDAC6-IN-44
目录号：
HY-162630
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z