2. Gene
  3. CDK17 - cyclin dependent kinase 17 Gene

CDK17 - cyclin dependent kinase 17 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞周期蛋白依赖性激酶 17

种属: Homo sapiens

同用名: PCTK2; PCTAIRE2

基因 ID: 5128 | 基因类型: protein coding

关于 CDK17

Cytogenetic location: 12q23.1 Genomic coordinates (GRCh38): 12:96,278,225-96,400,439 (from NCBI)

This gene has 12 transcripts (splice variants), 268 orthologues and 26 paralogues. Ubiquitous expression in brain (RPKM 21.3), testis (RPKM 15.1) and 24 other tissues.

功能概要

该基因编码的蛋白质属于蛋白激酶 ser/thr 家族的 cdc2/cdkx 亚家族。它与被认为在终末分化神经元中起作用的大鼠蛋白质具有相似性。已发现编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2010 年 7 月]

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]

CDK17 基因产物(2)

mRNA Protein Name
NM_001170464.4 NP_001163935.1 cyclin-dependent kinase 17 isoform 2
NM_002595.5 NP_002586.2 cyclin-dependent kinase 17 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15161933 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDK17 蛋白结构

Pkinase

Pkinase: Protein kinase domain (193 - 473)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 523 a.a.
蛋白主名 其他名称

cyclin-dependent kinase 17

PCTAIRE-motif protein kinase 2

CDK17 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CDK17 Q00537 BICDL2 Homo sapiens A1A5D9
Y2H Array
32296183
种属内
CDK17 Q00537 BICDL2 Homo sapiens A1A5D9
Y2H Prey Pooling
32296183
种属内
CDK17 Q00537 YWHAZ Homo sapiens P63104
Anti Tag CoIP
33961781
种属内
CDK17 Q00537 YWHAZ Homo sapiens P63104
Pull Down
15161933
种属内
CDK17 Q00537 YWHAE Homo sapiens P62258
Crosslink
36931259
种属内
CDK17 Q00537 CDK16 Homo sapiens Q00536
Anti Tag CoIP
33961781
种属内
CDK17 Q00537 DPY30 Homo sapiens Q9C005
Y2H Prey Pooling
32296183
种属内
CDK17 Q00537 DPY30 Homo sapiens Q9C005
Validated Y2H
32296183
种属内
CDK17 Q00537 DPY30 Homo sapiens Q9C005
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spastic Paraplegia 16, X-Linked

SPG16

Hereditary Spastic Paraplegia 16

X-Linked Spastic Paraplegia Type 16

Spastic Paraplegia 16, X-Linked, Complicated

X-Linked Spastic Paraplegia 16

Spastic Paraplegia 16

Spastic Paraplegia-16, X-Linked, Complicated
Spastic Paraplegia 12, Autosomal Dominant

SPG12

Hereditary Spastic Paraplegia 12

Autosomal Dominant Spastic Paraplegia Type 12

Autosomal Dominant Spastic Paraplegia 12

Spastic Paraplegia 12

Spastic Paraplegia-12

Paraplegia, Spastic, Autosomal Dominant, Type 12
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-137346 DD-03-156 Degrader 99.63% 否
HY-RS02369 CDK17 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CDK17 VGNC VGNC:108225
Felis catus CDK17 VGNC VGNC:68736
Macaca mulatta CDK17 VGNC VGNC:71161
Rattus norvegicus CDK17 RGD RGD:1565593
Mus musculus CDK17 MGD MGI:97517
Bos taurus CDK17 VGNC VGNC:27120
Others CDK17 NCBI
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